Fabrication and crushing behavior of low density carbon fiber composite pyramidal truss structures

A new method for fabricating carbon fiber composite pyramidal truss cores was developed based on the molding hot-press technique. In this method, all the continuous fibers of composite are aligned in the direction of struts and thus, the truss structure can fully exploit the intrinsic strength of the fiber reinforced composite. The microstructure and organizations of fibers of fabricated composite structures were examined using scanning electron microscope. The crushing response of the truss cores was also investigated and the corresponding failure modes were studied and complemented with an analytic model of the core crushing response. Our results show that the fabricated low-density truss cores have superior compressive strength and thus, could be used in development of novel lightweight multifunctional structures.     

The ANFIS-PSO strategy as a novel method to predict interfacial tension of hydrocarbons and brine

The interfacial tension of hydrocarbons and brine is known as one of the important parameters which are measured in petroleum and petrochemical industries for example the interfacial tension has straight effect on trapping of oil in a reservoir. In the present work the Adaptive neuro-fuzzy inference system (ANFIS) algorithm was used as a novel approach for estimation of interfacial tension between hydrocarbons and brine as function of pressure, temperature, carbon number of hydrocarbon and ionic strength of brine then the particle swarm optimization (PSO) was used to optimize the predicting model parameters.in order to better evaluation of performance of predicting algorithm the coefficient of determination (R²), average absolute relative deviation (AARD) and root mean squared error (RMSE) were estimated for different steps. The outcomes of this investigation expressed that proposed model has high potential for prediction of interfacial tension between hydrocarbons and brine.     

Fibril density reduction in keratoconic corneas

This study aims to estimate the reduction in collagen fibril density within the central 6 mm radius of keratoconic corneas through the processing of microstructure and videokeratography data. Collagen fibril distribution maps and topography maps were obtained for seven keratoconic and six healthy corneas, and topographic features were assessed to detect and calculate the area of the cone in each keratoconic eye. The reduction in collagen fibril density within the cone area was estimated with reference to the same region in the characteristic collagen fibril maps of healthy corneas. Together with minimum thickness and mean central corneal refractive power, the cone area was correlated with the reduction in the cone collagen fibrils. For the corneas considered, the mean area of keratoconic cones was 3.30 ± 1.90 mm². Compared with healthy corneas, fibril density in the cones of keratoconic corneas was lower by as much as 35%, and the mean reduction was 17 ± 10%. A linear approximation was developed to relate the magnitude of reduction to the refractive power, minimum corneal thickness and cone area (R² = 0.95, p < 0.001). Outside the cone area, there was no significant difference between fibril arrangement in healthy and keratoconic corneas. The presented method can predict the mean fibril density in the keratoconic eye''s cone area. The technique can be applied in microstructure-based finite-element models of the eye to regulate its stiffness level and the stiffness distribution within the areas affected by keratoconus.     

Nanoparticulation of enzymatically cross-linked whey proteins to encapsulate caffeine via microemulsification/heat gelation procedure

A co-surfactant free microemulsion was formulated with sunflower oil, span 80 and whey protein solution and used as nanoreactor to generate caffeine-enveloping capsules through heat gelation of protein. Transglutaminase-induced cross-linking of proteins prior to microemulsification decreased the mean diameter from 478 to 318 nm for core-free particles and from 232 to 118 nm for capsules. As well, the lower limit of capsules size decreased from 78 nm to 45 nm due to enzymatic cross-linking. Scanning electron microscopy showed that morphology of particles and capsules was not completely spherical which was attributed to the protrusion of protein molecules out of aqueous droplets during gelation. The enzymatic treatment yielded in particles with higher glass transition temperature due to the reinforced structure of particulate gel. Fourier transform infrared spectroscopy confirmed the structural changes in proteins by heat and establishment of covalent cross-linkages by the enzyme action manifested by a band at 1078 cm⁻¹.     

The autoregulation of the skin microcirculation in healthy subjects and diabetic patients with and without vascular complications

PURPOSE: To identify risk factors for mortality after postoperative myocardial infarction. METHOD: Retrospective study of 266 patients. RESULTS: The crude in-hospital mortality rate was 25%. This was more than twice as high as the mortality rate in patients admitted from home with an acute myocardial infarction. Women with postoperative infarction were the same age as men, but had a lower Acute Physiology and Chronic Health Evaluation (APACHE) II score prior to infarction (P = 0.03) and a higher crude mortality rate. Multivariate analysis showed that female gender (relative risk 2.2, 95% confidence limits 1.2 to 4.2), current cigarette smoking (relative risk 2.3 [1.2 to 4.7]), a history of congestive heart failure (relative risk 2.1 [1.04 to 4.1], resuscitation status (relative risk 8.1 [2.0 to 32.9]), and high preoperative APACHE II score were significant independent predictors of in-hospital mortality. CONCLUSION: Postoperative myocardial infarction is one of the most serious events a patient can experience. Women and current smokers are at especially high risk for mortality after postoperative myocardial infarction.     

Trans-free Iranian vanaspati through enzymatic and chemical transesterification of triple blends of fully hydrogenated soybean,rapeseed and sunflower oils

Production of trans-free Iranian vanaspati through enzymatic and chemical transesterification of triple blends of fully hydrogenated soybean (FHSBO), rapeseed (RSO) and sunflower (SFO) oils was investigated. The slip melting point (SMP), solid fat content (SFC) at 10–40 °C and induction period of oxidation at 120 °C (IP₁₂₀) of the transesterified and initial blends were evaluated. Results indicated that all the enzymatically and chemically transesterified blends had lower SMP, SFC and IP₁₂₀ than their initial blends. No significant differences (P < 0.05) were observed between the SMP of enzymatically and chemically transesterified blends. Some enzyme treated blends had higher SFC at some temperatures than chemically transesterified ones. Enzymatically transesterified blends had higher IP₁₂₀ than those prepared by chemical transesterification. Correlation between SFC at 20 °C and saturated fatty acid (SFA) content, and between SMP and SFA of transesterified blends indicated that the SFA must be between 27.2% and 36.6% for enzymatic and 28.4% and 37.8% for chemical transesterification to obtain transesterified fats suitable for use as vanaspati.     

Simultaneous Culturing of Cell Monolayers and Spheroids on a Single Microfluidic Device for Bridging the Gap between 2D and 3D Cell Assays in Drug Research

Two‐dimensional (2D) cell cultures have been the primary screening tools to predict drug impacts in vitro for decades. However, owing to the lack of tissue‐specific architecture of 2D cultures, secondary screening using three‐dimensional (3D) cell culture models is often necessary. A microfluidic approach that facilitates side‐by‐side 2D and 3D cell culturing in a single microchannel and thus combines the benefits of both set‐ups in drug screening; that is, the uniform spatiotemporal distributions of oxygen, nutrients, and metabolic wastes in 2D, and the tissue‐like architecture, cell–cell, and cell–extracellular matrix interactions only achieved in 3D. The microfluidic platform is made from an organically modified ceramic material, which is inherently biocompatible and supports cell adhesion (2D culture) and metal adhesion (for integration of impedance electrodes to monitor cell proliferation). To induce 3D spheroid formation on another area, a single‐step lithography process is used to fabricate concave microwells, which are made cell‐repellant by nanofunctionalization (i.e., plasma porosification and hydrophobic coating). Thanks to the concave shape of the microwells, the spheroids produced on‐chip can also be released, with the help of microfluidic flow, for further off‐chip characterization after culturing. In this study, the methodology is evaluated for drug cytotoxicity assessment on human hepatocytes.     

Firefly-inspired algorithm for discrete optimization problems: An application to manufacturing cell formation

The canonical firefly algorithm is basically developed for continuous optimization problems. However, lots of practical problems are formulated as discrete optimization problems. The main purpose of this paper is to present the discrete firefly algorithm (DFA) to solve discrete optimization problems. In the DFA, we define a firefly's position in terms of changes of probabilities that will be in one state or the other. Then by using this metaheuristic algorithm, the manufacturing cell formation problem is solved. To illustrate the behavior of the proposed model and verify the performance of the algorithm, we introduce a number of numerical examples to illustrate the use of the foregoing algorithm. The performance evaluation shows the effectiveness of the DFA. The proposed metaheuristic algorithm should thus be useful to both researchers and practitioners.