Satoshi Aya  Pter Salamon  Daniel A. Paterson  John M. D. Storey  Corrie T. Imrie  Fumito Araoka  Antal Jkli  gnes Buka 《Advanced Materials Interfaces》2019,6(9)

Mechanically responsive organic materials can change their viscoelastic properties in response to external stimuli. However, materials that exhibit highly contrasting viscoelastic properties coupled with fast and reversible switching between the states involved have remained elusive. Here, it is shown that a nonsymmetric photoresponsive liquid crystal dimer exhibits photoswitching of its viscoelastic properties (shear viscosity, storage, and loss moduli) with remarkable contrast of up to 10⁶ while transitioning between crystal and nematic phases. This switching is reversible and takes less than 100 s for both forward (trans‐cis photoisomerization) and backward (cis‐trans photoisomerization) reactions due to the coexistence of two allotropes containing two types of stereoisomers. This combination of highly contrasting viscoelastic behavior with fast and reversible switching establishes a whole new performance level for mechanically responsive organic materials and offers very considerable application potential in such diverse areas as photoswitchable adhesives, in vibration control, and as novel brakes.  相似文献   

    

Aya Essa  Toshio Yamanaka  Tomohiro Kobayashi  Narae Choi 《JAPAN ARCHITECTURAL REVIEW》2023,6(1):e12313

Displacement ventilation (DV) is considered an energy saving air conditioning system and is especially recommended for classrooms for providing cool clean air in the occupied zone. However, in the current pandemic situation, ventilation systems should be assessed in terms of infection-spread prevention as well. Hence, this study aims at assessing the efficiency of displacement ventilation in minimizing infection spread in lecture halls through investigating the effect of source position on the contaminant concentration distribution. The settings of a mid-size DV lecture hall in Osaka University, Japan was chosen as a case-study. Ten single-contaminant-source cases were simulated using CFD software. The cases were analyzed in terms of temperature distribution, contaminant diffusion pattern and vertical distribution, and breathing air quality using indices, such as local air quality index and scale of ventilation efficiency. The results demonstrated a considerable variation between cases in terms of contaminant distribution pattern, number of occupants affected, average inhaled-air quality, and diffusion radius. Accordingly, given the ventilation system design, best and worst case-scenarios were pointed out and factors affecting the variation were highlighted and further investigated to conclude the impact of each factor.  相似文献   

    

Kenta Homma  Tsukuru Masuda  Aya Mizutani Akimoto  Kenichi Nagase  Kazuyoshi Itoga  Teruo Okano  Ryo Yoshida 《Small (Weinheim an der Bergstrasse, Germany)》2017,13(21)

The propagation control of chemical waves via a pentagonal patterned structure in a self‐oscillating polymer brush composed of N‐isopropylacrylamide and a metal catalyst for the Belousov–Zhabotinsky (BZ) reaction is reported. The patterned self‐oscillating polymer brush is prepared by combining surface‐initiated atom transfer radical polymerization and maskless photolithography. Surface modification is confirmed by X‐ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, 3D measuring laser microscopy, and fluorescence microscopy. The polymer brush patterns are fabricated with gaps between the pentagonal regions, and investigations on the effect of the gap distance on the BZ reaction reveal that at the appropriate distance, chemical waves propagate across the array from the plane to the corner between the patterns. Unidirectional control is achieved not only in the 1D array, but also in a 2D curved array. This patterned self‐oscillating polymer brush is a novel and advantageous approach for creating an autonomous dynamic soft interface.  相似文献   

    

Trinh Thi My Nguyen  Yoko Ishida  Sae Kato  Aya Iwaki  Shingo Izawa 《Yeast (Chichester, England)》2018,35(7):465-475

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Taira Matsuo  Rie Komori  Minami Nakatani  Shiori Ochi  Aya Yokota-Nakatsuma  Junichi Matsumoto  Fuyuko Takata  Shinya Dohgu  Yasuhiro Ishihara  Kouichi Itoh 《International journal of molecular sciences》2022,23(14)

Acute brain inflammation after status epilepticus (SE) is involved in blood–brain barrier (BBB) dysfunction and brain edema, which cause the development of post-SE symptomatic epilepsy. Using pilocarpine-induced SE mice, we previously reported that treatment with levetiracetam (LEV) after SE suppresses increased expression levels of proinflammatory mediators during epileptogenesis and prevents the development of spontaneous recurrent seizures. However, it remains unclear how LEV suppresses neuroinflammation after SE. In this study, we demonstrated that LEV suppressed the infiltration of CD11b⁺CD45^high cells into the brain after SE. CD11b⁺CD45^high cells appeared in the hippocampus between 1 and 4 days after SE and contained Ly6G⁺Ly6C⁺ and Ly6G⁻Ly6C⁺ cells. Ly6G⁺Ly6C⁺ cells expressed higher levels of proinflammatory cytokines such as IL-1β and TNFα suggesting that these cells were inflammatory neutrophils. Depletion of peripheral Ly6G⁺Ly6C⁺ cells prior to SE by anti-Ly6G antibody (NIMP-R14) treatment completely suppressed the infiltration of Ly6G⁺Ly6C⁺ cells into the brain. Proteome analysis revealed the downregulation of a variety of inflammatory cytokines, which exhibited increased expression in the post-SE hippocampus. These results suggest that Ly6G⁺Ly6C⁺ neutrophils are involved in the induction of acute brain inflammation after SE. The proteome expression profile of the hippocampus treated with LEV after SE was similar to that after NIMP-R14 treatment. Therefore, LEV may prevent acute brain inflammation after SE by suppressing inflammatory neutrophil infiltration.  相似文献   

    

Fukiko Hihara  Hiroki Matsumoto  Mitsuyoshi Yoshimoto  Takashi Masuko  Yuichi Endo  Chika Igarashi  Tomoko Tachibana  Mitsuhiro Shinada  Ming-Rong Zhang  Gene Kurosawa  Aya Sugyo  Atsushi B. Tsuji  Tatsuya Higashi  Hiroaki Kurihara  Makoto Ueno  Yukie Yoshii 《International journal of molecular sciences》2022,23(10)

Peritoneal dissemination of pancreatic cancer has a poor prognosis. We have reported that intraperitoneal radioimmunotherapy using a ⁶⁴Cu-labeled antibody (⁶⁴Cu-ipRIT) is a promising adjuvant therapy option to prevent this complication. To achieve personalized ⁶⁴Cu-ipRIT, we developed a new in vitro tumor cell-binding assay (⁶⁴Cu-TuBA) system with a panel containing nine candidate ⁶⁴Cu-labeled antibodies targeting seven antigens (EGFR, HER2, HER3, TfR, EpCAM, LAT1, and CD98), which are reportedly overexpressed in patients with pancreatic cancer. We investigated the feasibility of ⁶⁴Cu-TuBA to select the highest-binding antibody for individual cancer cell lines and predict the treatment response in vivo for ⁶⁴Cu-ipRIT. ⁶⁴Cu-TuBA was performed using six human pancreatic cancer cell lines. For three cell lines, an in vivo treatment study was performed with ⁶⁴Cu-ipRIT using high-, middle-, or low-binding antibodies in each peritoneal dissemination mouse model. The high-binding antibodies significantly prolonged survival in each mouse model, while low-and middle-binding antibodies were ineffective. There was a correlation between in vitro cell binding and in vivo therapeutic efficacy. Our findings suggest that ⁶⁴Cu-TuBA can be used for patient selection to enable personalized ⁶⁴Cu-ipRIT. Tumor cells isolated from surgically resected tumor tissues would be suitable for analysis with the ⁶⁴Cu-TuBA system in future clinical studies.  相似文献   

    

Sudip Biswas  Aya Bridgeland  Samra Irum  Michael J. Thomson  Endang M. Septiningsih 《International journal of molecular sciences》2022,23(17)

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Takayuki Kobayashi  Hiroyuki Uchino  Eskil Elmr  Yukihiko Ogihara  Hidetoshi Fujita  Shusuke Sekine  Yusuke Ishida  Iwao Saiki  Shoichiro Shibata  Aya Kawachi 《International journal of molecular sciences》2022,23(2)

Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction resulting from a systemic inflammatory response to infection, but the mechanism remains unclear. The mitochondrial permeability transition pore (MPTP) could play a central role in the neuronal dysfunction, induction of apoptosis, and cell death in SAE. The mitochondrial isomerase cyclophilin D (CypD) is known to control the sensitivity of MPTP induction. We, therefore, established a cecal ligation and puncture (CLP) model, which is the gold standard in sepsis research, using CypD knockout (CypD KO) mice, and analyzed the disease phenotype and the possible molecular mechanism of SAE through metabolomic analyses of brain tissue. A comparison of adult, male wild-type, and CypD KO mice demonstrated statistically significant differences in body temperature, mortality, and histological changes. In the metabolomic analysis, the main finding was the maintenance of reduced glutathione (GSH) levels and the reduced glutathione/oxidized glutathione (GSH/GSSG) ratio in the KO animals following CLP. In conclusion, we demonstrate that CypD is implicated in the pathogenesis of SAE, possibly related to the inhibition of MPTP induction and, as a consequence, the decreased production of ROS and other free radicals, thereby protecting mitochondrial and cellular function.  相似文献   

    

Aya S. Hassan  Dr. Jannette Wober  Prof. Günter Vollmer  Prof. Ashraf H. Abadi  Prof. Nermin S. Ahmed 《ChemMedChem》2022,17(7):e202100720

Tamoxifen (TAM) is a selective estrogen receptor modulator (SERM) with potential clinical benefits for all stages of breast cancer. TAM is primarily metabolized to more potent metabolites via polymorphic CYP2D6. This affects the clinical outcome of TAM treatment. Herein we report novel TAM analogues that can avoid metabolism via CYP2D6. The novel analogues bear a flexible skeleton. Compounds have either an ester group on ring C or homodiaminoalkoxy groups on rings B and C . Compound 6 (E/Z-4-[1-[4-(2-diethylaminoethoxy)phenyl]-3-(4-methoxyphenyl)-2-methyl[propenyl]phenol) was found to be ten-fold more potent than TAM on MCF-7 cells (GI₅₀=0.15 μM). It showed fivefold greater inhibitory activity on MDA-MB-231 cells than TAM (GI₅₀=1.71 μM). Compound 13 (4-{3,3-bis-[4-(3-dimethylaminopropoxy)phenyl]-2-methylallyl}methoxybenzene) was the most potent among the homodiaminoalkoxy derivatives (GI₅₀=0.44) on both MCF-7 and MDA-MB-231 cell lines, respectively. Furthermore, the COMPARE algorithm suggested that it has different molecular targets from those of some other reported anticancer drugs.  相似文献   

    

Hao Zhang  Hangbo Zhao  Xingyue Zhao  Chenkai Xu  Daniel Franklin  Abraham Vázquez-Guardado  Wubin Bai  Jeffrey Zhao  Kan Li  Giuditta Monti  Wei Lu  Aya Kobeissi  Limei Tian  Xin Ning  Xinge Yu  Sunita Mehta  Debashis Chanda  Yonggang Huang  Shuai Xu  Bethany E. Perez White  John A. Rogers 《Advanced functional materials》2021,31(23):2100576

Phototherapy represents an attractive route for treating a range of challenging dermatological diseases. Existing skin phototherapy modalities rely on direct UV illumination, although with limited efficacy in addressing disorders of deeper tissue and with requirements for specialized illumination equipment and masks to shield unaffected regions of the skin. This work introduces a skin-integrated optoelectronic device that incorporates an array of UVA (360 nm) light emitting diodes in layouts that match those of typical lesional plaques and in designs that couple to biocompatible, penetrating polymer microneedle light waveguides to provide optical access to deep skin. Monte Carlo simulations and experimental results in phantom skin suggest that these waveguides significantly enhance light delivery to deep skin, with a >4-fold increase for depths of >500 µm. In ex vivo human skin, the devices show reduced measures of phototoxicity compared to direct illumination and enhanced modulation of gene expression relevant to sclerosing skin diseases. These systems are also compatible with design principles in soft, skin-compatible electronics and battery-powered wireless operation. Collectively, the favorable mechanical and light delivery properties of these devices expand possibilities in targeting of deep skin lesions beyond those attainable with clinical-standard UV light therapy approaches.  相似文献