Thymoquinone effects on DMH-induced erythrocyte oxidative stress and haematological alterations during colon cancer promotion in rats

The effect of thymoquinone (TQ), the abundant component of black cumin seed (Nigella sativa) oil extract, was evaluated on 1,2-dimethylhydrazine (DMH)-induced erythrocyte oxidative stress and haematological perturbations during colon cancer promotion in rats. Two TQ approaches, the pre- and post-treatment, were used. DMH promoted erythrocyte oxidative damage in rats by enhancing lipid peroxidation (30%) and decreasing antioxidant enzymes activities (20–35%). This was associated with the decline of erythrocyte count, haemoglobin concentration and haematocrit (20%) and the count increase of white blood cell (60%) and platelet (180%). TQ pre-treatment repaired DMH-induced erythrocyte oxidative stress, anaemia, leukocytosis, and thrombocytosis and allowed a 60% of tumour incidence decline. TQ post-treatment exerted a slight effect on erythrocyte oxidative stress and reduced colon cancer incidence by 30% only. Thus, TQ efficacy in preventing DMH-induced colon cancer promotion was related to its virtue antioxidant effect on erythrocyte oxidative stress.     

Antioxidation mechanism of rosmarinic acid, identification of an unstable quinone derivative by the addition of odourless thiol

The antioxidation mechanism of rosmarinic acid was investigated. An AIBN-induced oxidation reaction of linoleate in the presence of rosmarinic acid produced one main product. The DPPH reaction of rosmarinic acid also gave two products, one of which corresponded to the product of the lipid system. Direct isolation of the products failed because of their instability. To the DPPH reaction, the addition of 1-dodecanethiol afforded three isolable adducts. Their structures revealed that the reaction produced quinone derivatives on either the caffeoyl or 2-oxyphenylpropanoyl moieties. However, the lipid oxidation afforded one quinone, which could convert to a thiol adduct. The HPLC of the reaction clarified that the antioxidation product of rosmarinic acid was the unstable quinone on the 2-oxyphenylpropanoyl moiety. This quinone formation was the first stage of the antioxidation of rosmarinic acid in the lipid system. The odourless 1-dodecanethiol is a useful reagent to identify the unstable quinone from polyphenol oxidation.     

Estimation of passive cooling efficiency for environmental design in Brazil

An estimation of passive cooling techniques was conducted for 14 cities in Brazil, using a fairly accurate algorithm that accounts for heat conduction, convection, radiation, and evaporation; this was done to determine the amount of heat gain/loss of room air, defined as a particular quantitative index for passive techniques. Heat gains and losses were calculated for four envelope conditions - namely, insulated, high-albedo, wet surface, and a combination of the previous two - and compared to a case assumed to be the standard condition. A conclusion drawn was that a passive design is efficient in decreasing the need for cooling in typical dwellings in Brazil; solutions should differ with regional climate characteristics. In semi-arid areas, evaporative cooling showed the best results. Reduced heat gain was found during the warm seasons for all cities, along with increased heat gain during the cool seasons for mid-latitude cities. In particular, a combination of high-albedo enveloping and evaporation can greatly decrease heat gain in building walls. High-albedo surfaces in the sub-tropical areas found in southern Brazil are more efficient. It is suggested that passive techniques should be conceived in such a way so as to work during the cooling season and be disabled during mild ones.     

Preparation of Cu2ZnSnS4 thin films by sulfurizing electroplated precursors

Cu₂ZnSnS₄ (CZTS) thin films were prepared by sulfurizing precursors deposited by electroplating. The precursors (Cu/Sn/Zn stacked layers) were deposited by electroplating sequentially onto Mo-coated glass substrates. Aqueous solutions containing copper sulfate for Cu plating, tin sulfate for Sn plating and zinc sulfate for Zn plating were used as the electrolytes. The precursors were sulfurized by annealing with sulfur at temperatures of 300, 400, 500 and 600 °C in an N₂ gas atmosphere. The X-ray diffraction peaks attributable to CZTS were detected in thin films sulfurized at temperatures above 400 °C. A photovoltaic cell using a CZTS thin film produced by sulfurizing an electroplated Sn-rich precursor at 600 °C exhibited an open-circuit voltage of 262 mV, a short-circuit current of 9.85 mA/cm² and an efficiency of 0.98%.     

An analysis of the length of hospital stay for cataract patients in Japan using the discrete-type proportional hazard model

We analyze the length of hospital stays of patients hospitalized for cataract and related diseases (Diagnosis Related Groups (DRG) 2041) in Japan, utilizing the data pertaining to 3436 patients on whom one-eye lens operations are performed. We use the discrete-type proportional hazard model to analyze variables that may affect the length of stay.     

Low‐cost dye‐sensitized solar cells with ball‐milled tellurium‐doped graphene as counter electrodes and a natural sensitizer dye

This paper presents a facile and economic development of dye‐sensitized solar cells using a nonprecious counter electrode made from ball‐milled tellurium‐doped graphene (Te‐Gr) and a natural sensitizer extracted from Calotropis gigantea leaves. The prepared materials were characterized using various techniques, such as Raman spectroscopy, X‐ray diffraction (XRD), atomic force microscopy (AFM), impedance spectroscopy, and scanning electron microscopy with built‐in energy‐dispersive X‐ray spectroscopy (SEM with EDS). The electrochemical activity of the produced counter electrodes and the impedance of the fabricated cells were examined and discussed to devise plans for future enhancement of cell performance. A clear pattern of improvement was found when using cost‐effective Te‐Gr relative to the costly platinum counter electrodes, especially when compared with cells employing another natural sensitizer. The results show approximately 51% enhancement over chlorophyll‐based cells made from spinach, where the added advantage in our approach is the utilization of an abundant plant extract with little nutritional appeal.     

The effect of a periodic tangential magnetic field on the stability of a horizontal magnetic fluid sheet

The current article aims at investigating the effect of a periodic tangential magnetic field on the stability of a horizontal flat sheet. The media were considered porous, the three viscous‐fluid layers were initially streaming with uniform velocities, and the magnetic field admitted the presence of free‐surface currents. Furthermore, the transfer of mass and heat phenomenon was taken into account. The analysis, in this paper, was followed by the viscous potential theory. Moreover, the stability of the boundary‐value problem resulted in coupled second‐order linear differential equations with damping and complex coefficients. In regard to the uniform and periodic magnetic field, the standard normal mode approach was applied to deduce a general dispersion relation and judge the stability criteria. In addition, several unfamiliar cases were reported, according to appropriate data choices. The stability conditions were theoretically analyzed, and the influences of the various parameters in the stability profile were identified through a set of diagrams. In accordance wth the oscillating field, the coupled dispersion equations were combined to give the established Mathieu equation. Therefore, the governed transition curves were, theoretically, obtained. Finally, the results were numerically confirmed.     

Dependence of reconstructed image characteristics on the observation condition in light-in-flight recording by holography

We analyze the dependence of the reconstructed image characteristic on the observation condition in the light-in-flight recording by holography both theoretically and experimentally. This holography makes it possible to record a propagating light pulse. We have found that the shape of the reconstructed image is changed when the observation position is vertically moved along the hologram plane. The reconstructed image is numerically simulated on the basis of the theory and is experimentally obtained by using a 373 fs pulsed laser. The numerical results agree with the experimental result, and the validity of the theory is verified. Also, experimental results are analyzed and the restoration of the reconstructed image is discussed.