Vagueness Intuitions and the Mobility of Cognitive Sortals

One feature of vague predicates is that, as far as appearances go, they lack sharp application boundaries. I argue that we would not be able to locate boundaries even if vague predicates had sharp boundaries. I do so by developing an idealized cognitive model of a categorization faculty which has mobile and dynamic sortals (??classes??, ??concepts?? or ??categories??) and formally prove that the degree of precision with which boundaries of such sortals can be located is inversely constrained by their flexibility. Given the literature, it is plausible that we are appropriately like the model. Hence, an inability to locate sharp boundaries is not necessarily because there are none; boundaries could be sharp and it is plausible that we would nevertheless be unable to locate them.     

Case Study – The Making of an Institutional Crisis: The Mass Release of Inmates by a Correctional Agency

A US state correctional agency inadvertently released a large numbers of inmates before expiration of their sentences. This created an institutional crisis, for three reasons. First, the correctly timed release of inmates is unequivocally central the agency's core mission. Second, the early releases were consequential, in that serious crimes were committed by those only out of prison because of early release. Third, a citizen alerted the agency of an early‐release calculation for a particular offender, but the agency failed to act on this information. The correctional agency responded to this crisis by changing both its operating procedure and its culture.     

Experimental-numerical study and optimization of sound insulation of a finite composite cylinder

The aircraft fuselage is idealized as a composite cylinder, its vibroacoustic properties are studied both experimentally and numerically, and a minimization of the inner pressure of a composite cylinder is conducted with the genetic algorithm (GA). In the optimization, the Acoustic Transfer Vector (ATV), which comes from the boundary element method, builds the relationship between the structural surface velocity and the sound pressure at the specific filed points. Results show that the noise reduction obtained by the experimental and numerical methods have a good agreement; the optimization method which combines GA and ATV show high efficiency and robustness; increase of the bending stiffness of the cylinder can improve the noise reduction at low frequencies; both the reduction of weight and the increase of noise insulation can be achieved by the optimization of the layup at different regions of the cylinder individually.     

Ester-functionalized poly(3-alkylthiophene) copolymers: Synthesis,physicochemical characterization and performance in bulk heterojunction organic solar cells

The introduction of functional moieties in the donor polymer (side chains) offers a potential pathway toward selective modification of the nanomorphology of conjugated polymer:fullerene active layer blends applied in bulk heterojunction organic photovoltaics, pursuing morphology control and solar cell stability. For this purpose, two types of poly(3-alkylthiophene) random copolymers, incorporating different amounts (10/30/50%) of ester-functionalized side chains, were efficiently synthesized using the Rieke method. The solar cell performance of the functionalized copolymers was evaluated and compared to the pristine P3HT:PCBM system. It was observed that the physicochemical and opto-electronic characteristics of the polythiophene donor material can be modified to a certain extent via copolymerization without (too much) jeopardizing the OPV efficiency, as far as the functionalized side chains are introduced in a moderate ratio (<30%) and that preference is given to side chains with a small molar volume. A range of complementary techniques – UV–Vis spectroscopy, (modulated temperature) differential scanning calorimetry, transmission electron microscopy and X-ray diffraction analysis – indicated that variations in polymer crystallinity, while maintaining a high level of regioregularity, are probably the main factor responsible for the observed differences.     

Computing of the actual shape of removed material for five-axis flat-end milling

This paper describes an algorithm that predicts the shape of material removed by a flat-end milling tool, and this may be used to compute machining strip width and scallop height at different positions of the tool path track. The algorithm computes swept sections, profiles which are swept by a moving tool bottom by passing through given planes. The technique is applicable for finish and semi-finish multi-axis milling strategies that use flat-end tools. For these strategies, the algorithm complexity can be reduced from computation of the 3D envelope of swept volumes to computation of plane-circle intersections. A new adaptive derivative-free method to sample tool motion provides robust means to generate intermediate tool positions. The step length is constrained by and dependent on different geometrical measures. At each point of a tool path, in the plane perpendicular to the cutting direction, the bottom profile of the swept section is an estimate of the profile of material left. By calculating the distance between part geometry and the computed profile of removed material, machining strip width and a scallop profile can be derived. These results can be used by tool path generation and validation routines to accurately determine the step-over between tool path tracks and surface quality.     

Mutations Closer to the Active Site Improve the Promiscuous Aldolase Activity of 4‐Oxalocrotonate Tautomerase More Effectively than Distant Mutations

The enzyme 4‐oxalocrotonate tautomerase (4‐OT), which catalyzes enol–keto tautomerization as part of a degradative pathway for aromatic hydrocarbons, promiscuously catalyzes various carbon–carbon bond‐forming reactions. These include the aldol condensation of acetaldehyde with benzaldehyde to yield cinnamaldehyde. Here, we demonstrate that 4‐OT can be engineered into a more efficient aldolase for this condensation reaction, with a >5000‐fold improvement in catalytic efficiency (k_cat/K_m) and a >10⁷‐fold change in reaction specificity, by exploring small libraries in which only “hotspots” are varied. The hotspots were identified by systematic mutagenesis (covering each residue), followed by a screen for single mutations that give a strong improvement in the desired aldolase activity. All beneficial mutations were near the active site of 4‐OT, thus underpinning the notion that new catalytic activities of a promiscuous enzyme are more effectively enhanced by mutations close to the active site.