全文获取类型
收费全文 | 2233篇 |
免费 | 7篇 |
专业分类
化学工业 | 17篇 |
建筑科学 | 3篇 |
能源动力 | 2篇 |
轻工业 | 30篇 |
石油天然气 | 2篇 |
无线电 | 2篇 |
一般工业技术 | 8篇 |
冶金工业 | 2173篇 |
原子能技术 | 1篇 |
自动化技术 | 2篇 |
出版年
2021年 | 2篇 |
2019年 | 4篇 |
2016年 | 1篇 |
2015年 | 2篇 |
2014年 | 2篇 |
2013年 | 1篇 |
2012年 | 1篇 |
2011年 | 4篇 |
2010年 | 4篇 |
2006年 | 5篇 |
2005年 | 1篇 |
2004年 | 5篇 |
2003年 | 7篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1999年 | 68篇 |
1998年 | 739篇 |
1997年 | 428篇 |
1996年 | 266篇 |
1995年 | 155篇 |
1994年 | 114篇 |
1993年 | 117篇 |
1992年 | 13篇 |
1991年 | 20篇 |
1990年 | 15篇 |
1989年 | 28篇 |
1988年 | 16篇 |
1987年 | 19篇 |
1986年 | 22篇 |
1985年 | 22篇 |
1983年 | 1篇 |
1982年 | 8篇 |
1981年 | 13篇 |
1980年 | 12篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1977年 | 33篇 |
1976年 | 66篇 |
1975年 | 5篇 |
1971年 | 1篇 |
1965年 | 1篇 |
1959年 | 3篇 |
1958年 | 1篇 |
1955年 | 1篇 |
1954年 | 1篇 |
1948年 | 2篇 |
1909年 | 1篇 |
1890年 | 3篇 |
排序方式: 共有2240条查询结果,搜索用时 0 毫秒
101.
CJ Gore SC Little AG Hahn GC Scroop KI Norton PC Bourdon SM Woolford JD Buckley T Stanef DP Campbell DB Watson DL Emonson 《Canadian Metallurgical Quarterly》1997,75(2):136-143
Patients with craniocervical mandibular (TMD) disorders can present with tinnitus as a primary or secondary complaint. The embryology and functional anatomy of the middle ear, temporomandibular joint, muscles of mastication and associated tendons, ligaments, blood vessels, nerves and lymphatics was found to be helpful in establishing etiologic concepts which relate tinnitus to these temporomandibular disorders. In addition to etiologic concepts, treatment modalities are described. The authors relate their experiences as well as those of others with different patient populations. 相似文献
102.
H Inoue J Ferrer M Warren-Perry Y Zhang H Millns RC Turner SC Elbein CL Hampe BK Suarez N Inagaki S Seino MA Permutt 《Canadian Metallurgical Quarterly》1997,46(3):502-507
The septate gregarine parasites of flour beetles (Tribolium spp.) include Gregarina minuta Ishii, 1914, a relatively small species in which both primite and satellite possess an obvious protomerite, and a larger species that lacks the satellite protomerite. The latter species has been placed in the genera Didymophyes and Hirmocystis by various authors, but studies reported here demonstrate that this species, herein described as Gregarina triboliorum, exhibits early pairing and produces oocyst chains, both characteristics of the genus Gregarina. The oocysts of this new species are described for the first time. In addition, experimental infections using oocyst from single gametocysts reveal that oocyst chain number is variable but is typically 1, 2, or 4. Prior experiments involving a related beetle, Tenebrio molitor, demonstrated extreme host specificity within the 4 Gregarina species parasitizing larval and adult hosts. However, G. triboliorum is not limited either stadially or specially, infecting both adults and larvae of Tribolium confusum and Tribolium castaneum. 相似文献
103.
104.
SC Crepaldi-Alves EM Carneiro JR Bosqueiro AC Boschero 《Canadian Metallurgical Quarterly》1997,30(3):359-361
We studied the synergistic effect of glucose and prolactin (PRL) on insulin secretion and GLUT2 expression in cultured neonatal rat islets. After 7 days in culture, basal insulin secretion (2.8 mM glucose) was similar in control and PRL-treated islets (1.84 +/- 0.06% and 2.08 +/- 0.07% of the islet insulin content, respectively). At 5.6 and 22 mM glucose, insulin secretion was significantly higher in PRL-treated than in control islets, achieving 1.38 +/- 0.15% and 3.09 +/- 0.21% of the islet insulin content in control and 2.43 +/- 0.16% and 4.31 +/- 0.24% of the islet insulin content in PRL-treated islets, respectively. The expression of the glucose transporter GLUT2 in B-cell membranes was dose-dependently increased by exposure of the islet to increasing glucose concentrations. This effect was potentiated in islets cultured for 7 days in the presence of 2 micrograms/ml PRL. At 5.6 and 10 mM glucose, the increase in GLUT2 expression in PRL-treated islets was 75% and 150% higher than that registered in the respective control. The data presented here indicate that insulin secretion, induced by different concentrations of glucose, correlates well with the expression of the B-cell-specific glucose transporter GLUT2 in pancreatic islets. 相似文献
105.
T Goldman AL Hallin CM Hoffman LE Piilonen D Preston RD Bolton MD Cooper JS Frank PA Heusi GE Hogan FG Mariam HS Matis RE Mischke VD Sandberg GH Sanders U Sennhauser R Werbeck RA Williams D Grosnick SC Wright SL Wilson R Hofstadter EB Hughes MW Ritter VL Highland J McDonough 《Canadian Metallurgical Quarterly》1987,36(5):1543-1546
106.
107.
SC Wright U Schellenberger H Wang DH Kinder JW Talhouk JW Larrick 《Canadian Metallurgical Quarterly》1997,186(7):1107-1117
The 24-kD apoptotic protease (AP24) is a serine protease that is activated during apoptosis and has the capacity to activate internucleosomal DNA fragmentation in isolated nuclei. This study examined the following: (a) the functional relationship between AP24 and the CPP32-like proteases of the caspase family; and (b) whether activation of CPP32-like proteases is sufficient to commit irreversibly a cell to apoptotic death. In three different leukemia cell lines, we showed that agents that directly (carbobenzoxy-Ala-Ala-borophe (DK120) or indirectly inhibit activation of AP24 (protein kinase inhibitors, basic fibroblast growth factor, tosylphenylalaninechloromethylketone, and caspase inhibitors) protected cells from apoptosis induced by TNF or UV light. Only the caspase inhibitors, however, prevented activation of CPP32-like activity as revealed by cleavage of the synthetic substrate, DEVD-pNa, by cell cytosols, and also by in vivo cleavage of poly (ADP-ribosyl) polymerase, a known substrate of CPP32. Activation of DEVD-pNa cleaving activity without apoptosis was also demonstrated in two variants derived from the U937 monocytic leukemia in the absence of exogenous inhibitors. Cell-permeable peptide inhibitors selective for CPP32-like proteases suppressed AP24 activation and apoptotic death. These findings indicate that CPP32-like activity is one of several upstream signals required for AP24 activation. Furthermore, activation of CPP32-like proteases alone is not sufficient to commit irreversibly a cell to apoptotic death under conditions where activation of AP24 is inhibited. 相似文献
108.
FG Gervais NA Thornberry SC Ruffolo DW Nicholson S Roy 《Canadian Metallurgical Quarterly》1998,273(27):17102-17108
Focal adhesion kinase (Fak) is a non-receptor protein-tyrosine kinase that stimulates cell spreading and motility by promoting the formation of contact sites between the cell and the extracellular matrix (focal adhesions). It suppresses apoptosis by transducing survival signals that emanate from focal adhesions via the clustering of transmembrane integrins by components of the extracellular matrix. We demonstrate that Fak is cleaved by caspases at two distinct sites during apoptosis. The sites were mapped to DQTD772, which was preferentially cleaved by caspase-3, and VSWD704, which was preferentially cleaved by caspase-6 and cytotoxic T lymphocyte-derived granzyme B. The cleavage of Fak during apoptosis separates the tyrosine kinase domain from the focal adhesion targeting (FAT) domain. The carboxyl-terminal fragments that are generated suppress phosphorylation of endogenous Fak and thus resemble a natural variant of Fak, FRNK, that inhibits Fak activity by preventing the localization of Fak to focal adhesions. The cleavage of Fak by caspases may thus play an important role in the execution of the suicide program by disabling the anti-apoptotic function of Fak. Interestingly, rodent Fak lacks an optimal caspase-3 consensus cleavage site although it is cleaved in murine cells undergoing apoptosis at an upstream site. This appears to be the first example of a caspase substrate where the cleavage sites are not conserved between species. 相似文献
109.
AJ Huang JE Manning TM Bandak MC Ratau KR Hanser SC Silverstein 《Canadian Metallurgical Quarterly》1993,120(6):1371-1380
Polymorphonuclear leukocytes (PMN) traverse an endothelial cell (EC) barrier by crawling between neighboring EC. Whether EC regulate the integrity of their intercellular adhesive and junctional contacts in response to chemotaxing PMN is unresolved. EC respond to the binding of soluble mediators such as histamine by increasing their cytosolic free calcium concentration ([Ca++]i) (Rotrosen, D., and J.I. Gallin. 1986. J. Cell Biol. 103:2379-2387) and undergoing shape changes (Majno, G., S. M. Shea, and M. Leventhal. 1969. J. Cell Biol. 42:617-672). Substances such as leukotriene C4 (LTC4) and thrombin, which increased the permeability of EC monolayers to ions, as measured by the electrical resistance of the monolayers, transiently increased EC [Ca++]i. To determine whether chemotaxing PMN cause similar changes in EC [Ca++]i, human umbilical vein endothelial cells (HUVEC) maintained as monolayers were loaded with fura-2. [Ca++]i was measured in single EC during PMN adhesion to and migration across these monolayers. PMN-EC adhesion and transendothelial PMN migration in response to formyl-methionyl-leucyl-phenylalanine (fMLP) as well as to interleukin 1 (IL-1) treated EC induced a transient increase in EC [Ca++]i which temporally corresponded with the time course of PMN-EC interactions. When EC [Ca++]i was clamped at resting levels with a cell permeant calcium buffer, PMN migration across EC monolayers and PMN induced changes in EC monolayer permeability were inhibited. However, clamping of EC [Ca++]i did not inhibit PMN-EC adhesion. These studies provide evidence that EC respond to stimulated PMN by increasing their [Ca++]i and that this increase in [Ca++]i causes an increase in EC monolayer permeability. Such [Ca++]i increases are required for PMN transit across an EC barrier. We suggest EC [Ca++]i regulates transendothelial migration of PMN by participating in a signal cascade which stimulates EC to open their intercellular junctions to allow transendothelial passage of leukocytes. 相似文献
110.