Capitalizing on a double crop: Recent advances in proso millet's transition to a food crop

Across the globe, strategies to adapt food production to a changing climate as well as to unforeseen events (such as a pandemic) are needed, for example, if farmers miss planting times due to abnormal weather patterns or harvests are lost. Such food security considerations represent reasons for why proso millet deserves a more prominent place at the table. It has one of the shortest growing seasons and water requirements among cereals and is already grown in rotation with other crops, for example, in the American Midwest. Yet, most consumers in the Western world are unfamiliar with it, which limits its market potential. Introducing proso millet to consumers requires development of products with acceptable textural and sensory attributes as well as convincing selling points. These can be found in its nutritional profile, as it is a gluten-free “ancient” grain and millet-based products frequently have low glycemic indices. This review presents a synthesis of recent studies that utilized processing strategies to advance proso millet functionality. Results are put into the context of the most frequently addressed compositional and functional attributes, organized in clusters. Diversity across varieties in amylose to amylopectin ratios presents an opportunity to utilize proso millet for foods with specific pasting requirements, as in bread versus pasta. Hydrothermal or pressure treatments may further adapt its functionality for baked goods. Bitterness remains an unsolved issue, even when decorticated material is used. In addition, heating dramatically lowers in vitro protein digestibility, whereas starch digestibility appears to be matrix dependent (more than raw material dependent).     

Ossa cordis and os aorta in the one-humped camel: Computed tomography,light microscopy and morphometric analysis

The present study describes the morphological characteristics of the camel heart Ossa cordis, and os aorta using computed tomography soft tissue window (CT) alongside 3D render volume reconstructions and light microscopy. The current study techniques demonstrated the Ossa cordis and os aorta in the cardiac window with more precision than the black and white (ghost), and angiography images. Transverse and sagittal CT images additionally demonstrated the presence of Ossa cordis and os aorta. This study is the first to record two small Ossa cordis sinistrum and one os aorta in the camel heart, in addition to the more commonly observed singular, large, os cordis dextrum. The os cordis dextrum was always located in the upper part of the interventricular septum, near to its junction with the atrium, forming an elongated rectangular shape when observed transversally. The wider cranial part was composed from bone, whereas the caudal aspect was narrow and contained both bone and cartilage. Light microscopy identified that the os cordis dextrum consisted of trabecular bone, marrow spaces, and hyaline cartilage. Two Ossa cordis sinistrum were detected on the left side of the heart, one in the right fibrous ring and another in the interventricular septum, microscopy showed that both contained only trabecular bone with osteocytes, osteoblasts, and osteoclasts. At the level of ascending aorta, there was also trabecular bone containing osteocytes, an os aorta.     

ThermoShield – ein Beitrag zur Wärmedämmung?

ThermoShield – a contribution to thermal insulation? For some time now, so called thermal coatings are being introduced onto the market. Advertisement to these products announce that these coatings reduce heating energy requirement in buildings considerably. These coatings are facade paintings, e.g the product “ThermoShield”, to which microscopic small ceramic bubbles are added. In the product data to these coatings, a heating energy saving up to 30% are mentioned. The manufacturer impute these saving to different effects of the “ThermoShield” coating. To check the upper mentioned promising product properties, the thermal behaviour of test specimens coated with “ThermoShield – Exterieur” are being studied within the scope of a research work at the University of Hannover. The evaluation of the measurement results showed, that the specimens coated with “ThermoShield” did not have the thermal properties expected and that this coating do not show any of the promised thermal insulating properties.     

Evaluation of process parameter of an automated dip-coating

Dip coating is a common technique for the optimization of metallic implants, whereas several steps during the procedure influence the coating. This study aims in the development of a coating apparatus and the evaluation of critical steps, such as mixing, immersion, retention and withdrawal velocity during the procedure. In addition the influence of the polymer solution viscosity, poly(d,l-lactide) dissolved in ethyl acetate, was analyzed. As a therapeutic drug, gentamicin was incorporated and the amount in the different coatings quantified. With increased withdrawal velocity and viscosity the thickness of the coating layer increased. This was accompanied by an increase in incorporated drug. The mixing, immersion and retention time had almost no effect. The viscosity of the polymer solution and the withdrawal velocity can therefore be used to modify bioactive coatings for optimized local drug loading.     

If you are able to control yourself, I will trust you: The role of perceived self-control in interpersonal trust.

The present research tested the hypothesis that perception of others' self-control is an indicator of their trustworthiness. The authors investigated whether, in interactions between strangers as well as in established relationships, people detect another person's self-control, and whether this perception of self-control, in turn, affects trust. Results of 4 experiments supported these hypotheses. The first 2 experiments revealed that participants detected another person's trait of self-control. Experiments 3 and 4 revealed that participants also detected the temporary depletion of another person's self-control. Confirming the authors' predictions, perceived trait and state self-control, in turn, influenced people's judgment of the other person's trustworthiness. In line with previous research, these findings support the positive value of self-control for relationships and highlight the role of perceived self-control for the development of a fundamental relationship factor: trust. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

The benefits of interpersonal regulatory fit for individual goal pursuit.

The present work examines whether individual goal pursuit is influenced by advice and suggestions from interaction partners whose regulatory orientation is perceived to fit (vs. not fit) the individual's orientation. We sought to investigate whether such interpersonal regulatory fit yields motivational consequences for goal pursuit that parallel those of intrapersonal regulatory fit. Furthermore, we investigated whether these effects occur in a symmetrical fashion for promotion- and prevention-oriented individuals. The results of 6 experiments revealed that promotion-oriented individuals profit from interpersonal regulatory fit, experiencing motivational benefits when receiving goal-relevant advice from promotion-oriented interaction partners; however, prevention-oriented individuals do not profit from prevention-oriented interaction partners. These findings support the proposal that regulatory fit can fruitfully be examined as an interpersonal phenomenon, highlighting the role that interaction partners may play in the pursuit of personal goals. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Toward Quantitative Models in Safety Assessment: A Case Study to Show Impact of Dose–Response Inference on hERG Inhibition Models

Due to challenges with historical data and the diversity of assay formats, in silico models for safety-related endpoints are often based on discretized data instead of the data on a natural continuous scale. Models for discretized endpoints have limitations in usage and interpretation that can impact compound design. Here, we present a consistent data inference approach, exemplified on two data sets of Ether-à-go-go-Related Gene (hERG) K+ inhibition data, for dose–response and screening experiments that are generally applicable for in vitro assays. hERG inhibition has been associated with severe cardiac effects and is one of the more prominent safety targets assessed in drug development, using a wide array of in vitro and in silico screening methods. In this study, the IC₅₀ for hERG inhibition is estimated from diverse historical proprietary data. The IC₅₀ derived from a two-point proprietary screening data set demonstrated high correlation (R = 0.98, MAE = 0.08) with IC_50s derived from six-point dose–response curves. Similar IC₅₀ estimation accuracy was obtained on a public thallium flux assay data set (R = 0.90, MAE = 0.2). The IC₅₀ data were used to develop a robust quantitative model. The model’s MAE (0.47) and R² (0.46) were on par with literature statistics and approached assay reproducibility. Using a continuous model has high value for pharmaceutical projects, as it enables rank ordering of compounds and evaluation of compounds against project-specific inhibition thresholds. This data inference approach can be widely applicable to assays with quantitative readouts and has the potential to impact experimental design and improve model performance, interpretation, and acceptance across many standard safety endpoints.