Lamb波传播特性研究

应用三维弹性理论对Lamb波频散曲线进行理论建模.在Lamb波主动监测系统中,应用Gabor小波变换理论分析Lamb波信号的时延及相位角,获得了板中Lamb波的相群速度频散曲线.比较理论曲线与实验数据,证明了三维弹性理论建模方法的有效性.     

深圳水晶岛规划设计

基于2008年深圳被联合国教科文组织授予"设计之都"称号,大都会建筑事务所(OMA)与URBANUS都市实践建筑事务所联合设计的深圳水晶岛规划设计方案建议在市民中心前广场,以"深圳创意中心"的概念和形式为城市的创意产业构建活     

太阳能-土壤源热泵系统在华北地区应用的模拟研究

本文针对我国华北地区冬季寒冷需要供暖、夏季炎热需要空调,但是全年冷热负荷很不平衡的气候特点,提出太阳能-土壤源热泵系统的联合运行方案。以北京地区1栋别墅建筑为研究对象,在其全年动态负荷的基础上,对系统进行设计计算,并对全年运行工况模拟分析,得到系统在全年运行过程中主要参数的变化情况,为该系统在华北地区的应用作初步性研究,为以后该系统的设计及工程应用提供参考。     

John Van Danacker让心脏说话

经验丰富的工程设计师John Van Danacker帮助Medtronic公司开发出让去纤颤器与网络沟通的科技当Medtronic公司(http://designnews.com.cn/0812-510.aspx)决定在2001年开发一套远程患者管理系统时,作为医疗     

电机改造 三种知名电机设计,性能极大提升

有时经过时间检验并证明行之有效的电机设计,可以得益于小的改变,也可以改善性能,或开辟新的应用可能性。这里有三个这样的例子,涉及三种类型非常不同的电机。一个是有刷直流电机设计,虽然其结构已经很紧凑,只是功率密度有拐点。由一个无车架直接     

上海燃气发展“十二五”规划解析

上海燃气发展“十二五”规划以沪府发[2011]92号文发布实施,作为“十二五”期间本市燃气行业发展的纲领性文件。文章着重通过比对“十一五”期末和“十二五”期末燃气行业发展的重点指标,阐述“十二五”期末本市燃气行业的预期目标,并指出期间需开展的相关工作。     

2014年法兰克福建筑与照明展

在2014年法兰克福建筑与照明展上,参展商们要从众多展商中脱颖而出、在照明市场中独树一帜实在不易。照明市场在持续增长,市场份额抢夺战亦将愈演愈烈。作为一项面向未来的广元技术,LED无疑是一大赢家。然而,在展会中展出LED产品的供应商数量亦是有增无减。差异化这一致胜关键——即供应商的“独特卖点”越来越难以辨明。不过,“独特产品”始终都有发展空间。真正创新技术的增长速度赶不上供应商数量的增加,因此看上去十分有限。至少表面上是如此！但如果用心寻找,我们还是能发现一些很有趣的概念和设想。     

浅谈筏板基础的设计

高层建筑中的筏板基础     

Effects of the oral administration of the products derived from milk fermentation by kefir microflora on immune stimulation

Nutritional status has a major impact on the immune system. Probiotic effects ascribed to fermented dairy products arise not only from whole microorganisms but also from metabolites (peptides, exopolysaccharides) produced during the fermentation. We recently demonstrated the immunomodulating capacity of kefir in a murine model. We now aimed at studying the immunomodulating capacity in vivo of the products derived from milk fermentation by kefir microflora (PMFKM) on the gut. BALB/c mice received the PMFKM for 2, 5 or 7 consecutive days. IgA+ and IgG+ cells were determined on histological slices of the small and large intestine. IL-4, IL-6, IL-10, IL-12, IFNgamma and TNFalpha were determined in the gut, intestinal fluid and blood serum. IL-6 was also determined in the supernatant of a primary culture of small intestine epithelial cells challenged with PMFKM. PMFKM up-regulated IL-6 secretion, necessary for B-cell terminal differentiation to IgA secreting cells in the gut lamina propria. There was an increase in the number of IgA+ cells in the small and large intestine. The increase in the number of IgA+ cells was accompanied by an increase in the number of IL-4+, IL-10+ and IL-6+ cells in the small intestine. Effects of PMFKM in the large intestine were less widely apparent than the ones observed at the small intestine lamina propria. All cytokines that increased in the small intestine lamina propria, also did so in blood serum, reflecting here the immunostimulation achieved in the gut mucosa. We observed that the PMFKM induced a mucosal response and it was able to up and down regulate it for protective immunity, maintaining the intestinal homeostasis, enhancing the IgA production at both the small and large intestine level. The opportunity exists then to manipulate the constituents of the lumen of the intestine through dietary means, thereby enhancing the health status of the host.     

Nanowire substrate-based laser scanning cytometry for quantitation of circulating tumor cells

We report on the development of a nanowire substrate-enabled laser scanning imaging cytometry for rare cell analysis in order to achieve quantitative, automated, and functional evaluation of circulating tumor cells. Immuno-functionalized nanowire arrays have been demonstrated as a superior material to capture rare cells from heterogeneous cell populations. The laser scanning cytometry method enables large-area, automated quantitation of captured cells and rapid evaluation of functional cellular parameters (e.g., size, shape, and signaling protein) at the single-cell level. This integrated platform was first tested for capture and quantitation of human lung carcinoma cells from a mixture of tumor cells and leukocytes. We further applied it to the analysis of rare tumor cells spiked in fresh human whole blood (several cells per mL) that emulate metastatic cancer patient blood and demonstrated the potential of this technology for analyzing circulating tumor cells in the clinical settings. Using a high-content image analysis algorithm, cellular morphometric parameters and fluorescence intensities can be rapidly quantitated in an automated, unbiased, and standardized manner. Together, this approach enables informative characterization of captured cells in situ and potentially allows for subclassification of circulating tumor cells, a key step toward the identification of true metastasis-initiating cells. Thus, this nanoenabled platform holds great potential for studying the biology of rare tumor cells and for differential diagnosis of cancer progression and metastasis.