Identifying FMRI model violations with lagrange multiplier tests

The standard modeling framework in functional magnetic resonance imaging (fMRI) is predicated on assumptions of linearity, time invariance and stationarity. These assumptions are rarely checked because doing so requires specialized software, although failure to do so can lead to bias and mistaken inference. Identifying model violations is an essential but largely neglected step in standard fMRI data analysis. Using Lagrange multiplier testing methods we have developed simple and efficient procedures for detecting model violations such as nonlinearity, nonstationarity and validity of the common double gamma specification for hemodynamic response. These procedures are computationally cheap and can easily be added to a conventional analysis. The test statistic is calculated at each voxel and displayed as a spatial anomaly map which shows regions where a model is violated. The methodology is illustrated with a large number of real data examples.     

Very Low Degree of Energetic Disorder as the Origin of High Mobility in an n‐channel Polymer Semiconductor

Charge transport is investigated in high‐mobility n‐channel organic field‐effect transistors (OFETs) based on poly{[N,N′‐bis(2‐octyldodecyl)‐naphthalene‐1,4,5,8‐bis(dicarboximide)‐2,6‐diyl]‐alt‐5,5′‐(2,2′‐bithiophene)} (P(NDI2OD‐T2), Polyera ActivInk? N2200) with variable‐temperature electrical measurements and charge‐modulation spectroscopy. Results indicate an unusually uniform energetic landscape of sites for charge‐carrier transport along the channel of the transistor as the main reason for the observed high‐electron mobility. Consistent with a lateral field‐independent transport at temperatures down to 10 K, the reorganization energy is proposed to play an important role in determining the activation energy for the mobility. Quantum chemical calculations, which show an efficient electronic coupling between adjacent units and a reorganization energy of a few hundred meV, are consistent with these findings.     

SiP(系统级封装)技术的应用与发展趋势(上)

一,SiP技术的产生背景 系统级封装SiP(System-In-Package)是将一个电子功能系统,或其子系统中的大部分内容,甚至全部都安置在一个封装内.这个概念看起来很容易理解,熟悉封装技术,又对电子装置或电子系统有所了解的人们一般都能够理解SiP的含义.但是如果试图对SiP使用严格的名词术语,进行精确的定义,却非常困难.SiP这一术语出现至今,虽然已经有好几年了,但是仍然没有,能够被广泛认同的定义;一般只是指出其包含的内容,或者指出其所具有的特征.Amkor公司认为SiP技术包括以下内容,或具有以下特征:     

Environmental effects on the electrical behavior of pentacene thin-film transistors with a poly(methyl methacrylate) gate insulator

The electrical properties of top-contact pentacene thin-film transistors (TFTs) with a poly(methyl methacrylate) (PMMA) gate dielectric were analyzed in air and vacuum environments. Compared to the vacuum case, the pentacene TFT in air exhibited lower drain currents and more pronounced shifts in the threshold voltage upon reversal of the gate voltage sweep direction, together with a decrease in the field-effect mobility. These characteristic variations were explained in terms of two distinctive actions of polar H₂O molecules in pentacene TFT. H₂O molecules were suggested to diffuse under the source and drain contacts and interrupt the charge injection into the pentacene film, whereas those that permeate at the pentacene/PMMA interface retard hole depletion in and around the TFT channel. The diffusion process was much slower than the permeation process. The degraded TFT characteristics in air could be recovered mostly by storing the device under vacuum, which suggests that the air instability of TFTs is due mainly to the physical adsorption of H₂O molecules within the pentacene film.     

Interpolation techniques for building a continuous map from discrete wireless sensor network data

Wireless sensor networks (WSNs) typically gather data at a discrete number of locations. However, it is desirable to be able to design applications and reason about the data in more abstract forms than in points of data. By bestowing the ability to predict inter‐node values upon the network, it is proposed that it will become possible to build applications that are unaware of the concrete reality of sparse data. This interpolation capability is realised as a service of the network. In this paper, the ‘map’ style of presentation has been identified as a suitable sense data visualisation format. Although map generation is essentially a problem of interpolation between points, a new WSN service, called the map generation service, which is based on a Shepard interpolation method, is presented. A modified Shepard method that aims to deal with the special characteristics of WSNs is proposed. It requires small storage, can be localised and integrates the information about the application domain to further reduce the map generation cost and improve the mapping accuracy. Empirical analysis has shown that the map generation service is an accurate, a flexible and an efficient method. Copyright © 2011 John Wiley & Sons, Ltd.     

Modular Ligation of Thioamide Functional Peptides onto Solid Cellulose Substrates

Hetero Diels‐Alder (HDA) cycloaddition – as an effective modular conjugation approach – is employed to graft thioamide endfunctional oligopeptides onto solid cyclopentadienyl (Cp) functional cellulose substrates generating cellulose‐peptide hybrid materials. The highly reactive Cp moieties serve as diene functionality in the consecutive HDA reaction on the biosubstrate surface. Oligopeptides (i.e., the model peptide Gly‐Gly‐Arg‐Phe‐Pro‐Trp‐Trp‐Gly and the antimicrobial peptide tritrpticin) are functionalized at their N‐termini employing strongly electron deficient thiocarbonyl thio compounds resulting in biomacromolecules bearing a thioamide endgroup. The dienophile‐ functional peptides readily undergo HDA reactions at ambient temperature and under mild conditions in solution with synthetic polymers as well as on solid (bio)substrates. An in‐depth investigation is provided of the influence of the temperature, the Lewis acid catalysis and the side group exchange of thioamide functional oligopeptides reacting with Cp terminated poly(methyl methacrylate) (M_n = 2100 g·mol^?1, PDI = 1.1) in homogenous solution as well as Cp functionalized cellulose in a heterogeneous system. To assess the success of the grafting reaction, the soluble samples were subjected to characterization methods such as size exclusion chromatography (SEC) and SEC‐electrospray ionization mass spectrometry (SEC‐ESI‐MS). The heterogeneous “grafting‐to” reactions were monitored using high resolution attenuated total reflection (ATR) Fourier transform infrared microscopy (HR‐FTIRM) imaging, X‐ray photoelectron spectroscopy (XPS) and elemental analysis. Evaluation via elemental analysis leads to quantitative peptide cellulose surface loading capacities.     

Texture characterization of Cu interconnects with different Ta-based sidewall diffusion barriers

X-ray diffraction is used to assess the texture of narrow lines and study the impact of different sidewall diffusion barrier materials. All the Ta-based barriers developed a strong 〈1 1 1〉 texture in the scaled geometry, with little effect from sidewall growth. Comparisons were made with blanket wafers, demonstrating the pined grain structure in the narrow lines and contrasting change in texture due to re-crystallization in the unconstrained film. Furthermore, patterned lines showed significant anti-symmetric plane distribution influenced by high strains and twinning along the lines.     

A 21.5% efficient Cu(In,Ga)Se2 thin‐film concentrator solar cell

Cu(In,Ga)Se₂ (CIGS) solar cells have been designed for operation under mildly concentrated sunlight. The absorber was deposited via a three‐stage evaporation process that has consistently yielded high‐performance one‐sun devices. The device structure reported here was modified by reducing the thickness of the CdS window/buffer layer to enhance the short‐circuit current at the expense of the open‐circuit voltage. Operation of the devices under optical enhancement leads to significant increases in the voltage and fill factor. At 14 suns, the open‐circuit voltage for this device was 736 mV, the fill factor was 80.5%, and the efficiency was 21.5%. This result represents the first report of a polycrystalline thin‐film solar cell with an efficiency in excess of 20%. Published in 2002 by John Wiley & Sons, Ltd.     

Tuning the Molecular Weight of the Electron Accepting Polymer in All‐Polymer Solar Cells: Impact on Morphology and Charge Generation

Molecular weight is an important factor determining the morphology and performance of all‐polymer solar cells. Through the application of direct arylation polycondention, a series of batches of a fluorinated naphthalene diimide‐based acceptor polymer are prepared with molecular weight varying from M_n = 20 to 167 kDa. Used in conjunction with a common low bandgap donor polymer, the effect of acceptor molecular weight on solar cell performance, morphology, charge generation, and transport is explored. Increasing the molecular weight of the acceptor from M_n = 20 to 87 kDa is found to increase cell efficiency from 2.3% to 5.4% due to improved charge separation and transport. Further increasing the molecular weight to M_n = 167 kDa however is found to produce a drop in performance to 3% due to liquid–liquid phase separation which produces coarse domains, poor charge generation, and collection. In addition to device studies, a systematic investigation of the microstructure and photophysics of this system is presented using a combination of transmission electron microscopy, grazing‐incidence wide‐angle X‐ray scattering, near‐edge X‐ray absorption fine‐structure spectroscopy, photoluminescence quenching, and transient absorption spectroscopy to provide a comprehensive understanding of the interplay between morphology, photophysics, and photovoltaic performance.     

Enhanced Photocurrent Production by Photosystem I Multilayer Assemblies

The long‐term success of photosynthetic organisms has resulted in their global superabundance, which is sustained by their widespread, continual mass‐production of the integral proteins that photocatalyze the chemical processes of natural photosynthesis. Here, a fast, general method to assemble multilayer films composed of one such photocatalytic protein complex, Photosystem I (PSI), onto a variety of substrates is reported. The resulting films, akin to the stacked thylakoid structures of leaves, consist of a protein matrix that is permeable to electrochemical mediators and contain a high concentration of photoelectrochemically active redox centers. These multilayer assemblies vastly outperform previously reported monolayer films of PSI in terms of photocurrent production when incorporated into an electrochemical system, and it is shown that these photocatalytic properties increase with the film thickness. These results demonstrate how the assembly of micron‐thick coatings of PSI on non‐biological substrates yields a biohybrid ensemble that manifests the photocatalytic activity of the film’s individual protein constituents, and represent significant progress toward affordable, biologically‐inspired renewable energy conversion platforms.