基于Mastercam平台等距曲面的开发研究

介绍Mastercam V9平台下C-Hook开发环境,讨论等距曲面的基本算法,解决相连多曲面的等距曲面的问题,给出等距曲面的误差控制方法,在Mastercam V9平台下实现等距曲面的开发.     

Haploinsufficiency of a Circadian Clock Gene Bmal1 (Arntl or Mop3) Causes Brain-Wide mTOR Hyperactivation and Autism-like Behavioral Phenotypes in Mice

Approximately 50–80% of children with autism spectrum disorders (ASDs) exhibit sleep problems, but the contribution of circadian clock dysfunction to the development of ASDs remains largely unknown. The essential clock gene Bmal1 (Arntl or Mop3) has been associated with human sociability, and its missense mutation is found in ASD. Our recent study found that Bmal1-null mice exhibit a variety of autism-like phenotypes. Here, we further investigated whether an incomplete loss of Bmal1 function could cause significant autism-like behavioral changes in mice. Our results demonstrated that heterozygous Bmal1 deletion (Bmal1^+/−) reduced the Bmal1 protein levels by ~50–75%. Reduced Bmal1 expression led to decreased levels of clock proteins, including Per1, Per2, Cry 1, and Clock but increased mTOR activities in the brain. Accordingly, Bmal1^+/− mice exhibited aberrant ultrasonic vocalizations during maternal separation, deficits in sociability and social novelty, excessive repetitive behaviors, impairments in motor coordination, as well as increased anxiety-like behavior. The novel object recognition memory remained intact. Together, these results demonstrate that haploinsufficiency of Bmal1 can cause autism-like behavioral changes in mice, akin to those identified in Bmal1-null mice. This study provides further experimental evidence supporting a potential role for disrupted clock gene expression in the development of ASD.     

机械化学促成可调谐光-电多功能响应二维杂化钙钛矿材料

二维有机-无机杂化钙钛矿因在光伏、光电子等领域的巨大应用潜力而备受关注.此外,该类材料具有突出的结构可调性和材料稳定性,为功能性质的设计调控及器件应用提供了丰富的材料设计平台.然而,将多种物理通道的性质整合实现材料的多功能性仍具有挑战性,而对其进行快速有效的调节更是难上加难.迄今为止,尚未成功实现可调谐的光电多通道响应...     

M23C6 precipitation and Si segregation promoted by deep cryogenic treatment aggravating pitting corrosion of supermartensitic stainless steel

The microstructure evolution and the pitting corrosion resistance of a supermartensitic stainless steel after deep cryogenic treatment process were clarified th...     

90 t超高功率电弧炉短流程生产P5钢的工艺实践

介绍了攀钢集团成都钢铁有限责任公司采用90 t超高功率电弧炉短流程生产P5钢的冶炼工艺,分析了生产技术难点,对生产过程中钢水P含量、合金加入方式、冶炼过程温度、精炼钢水化学成分的均匀性和稳定性、精炼钢包质量和钢锭质量等采取有效的技术控制措施,使短流程生产P5钢的目标得到实现,产品的性能指标满足标准要求.     

ISO和GB标准煤炭全水分测定报告值确定的探讨

通过对ISO标准和GB标准的比较,探讨根据其绝对误差来判断报告值的修约位数。     

基于双通道能量差的环网柜局放信号消噪方法

利用放电声音信号检测环网柜的局部放电具有信息量丰富、能够准确反映放电故障等特点而得到广泛应用,但放电声音信号的有效检测是一个难点.双通道录音在消噪领域中具有独特的优势,能够有效消除非平稳噪声,根据现场测量噪声干扰多为远距离的非平稳噪声,而局放信号为近距离声源的特点,提出了一种基于双通道能量差(PLD)的环网柜放电信号消...     

超高压处理对牡蛎中GII.4型诺如病毒的消减控制

诺如病毒（NoVs）是世界范围内引起非细菌性胃肠炎的主要病原体。为研究不同压力条件的超高压处理对牡蛎中NoVs消减控制的影响,将GⅡ.4型NoVs分别置于牡蛎消化腺匀浆和PBS缓冲液中,采用压力分别为200,300,400,500MPa,加压初始温度5℃,保压时间5 min进行处理,并以常压（0.1 MPa）处理为对照组。采用PMAxx-RT-qPCR与透射电子显微镜检测超高压处理后的NoVs,评价不同压力对牡蛎消化腺匀浆和PBS缓冲液中GⅡ.4型NoVs的消减效果;测定超高压处理后牡蛎丙二醛含量和蛋白质巯基含量,评价超高压处理对牡蛎中脂肪和蛋白质的影响。研究结果显示：PMAxx可有效区分感染性NoVs;qPCR检测发现经不同压力的超高压处理后,牡蛎消化腺匀浆和缓冲液中NoVs的RNA拷贝数均显著减少,当压力为500 MPa时,牡蛎和缓冲液中的RNA拷贝数减少量分别>3.49 lg(copies/μL)和>3.61 lg(copies/μL),均降至检测限以下;超高压处理对PBS缓冲液中NoVs的消减效果优于牡蛎消化腺匀浆,还可使牡蛎中脂肪氧化和蛋白质变性,然而,改变程度小...     

电站锅炉粉煤灰漂珠富集模拟研究

粉煤灰中的漂珠具有很好的工业再利用价值,常规湿法分选漂珠的方法因提纯溶剂的消耗量较大,导致成本较高.本文提出一种在旋风分离器底部送入灰气混合物,上部送入辅助风形成旋流进而富集漂珠的方法,采用欧拉-拉格朗日模型对富集装置内的气固两相流展开数值模拟,验证该方法的可行性;研究芯管高度、底部灰气混合物入射速度及上部辅助风送入速...