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151.
This work describes a framework that combines techniques from Adaptive Hypermedia and Natural Language processing in order to create, in a fully automated way, on-line information systems from linear texts in electronic format, such as textbooks. The process is divided into two steps: an off-line processing step, which analyses the source text, and an on-line step, which executes when a user connects to the system with a web browser, moment at which the contents and hyperlinks are generated. The framework has been implemented as the Welkin system, which has been used to build three adaptive on-line information sites in a quick and easy way. Some controlled experiments have been performed with real users aimed to provide positive feedback on the implementation of the system. 相似文献
152.
Diana H.P. Low Bharadwaj Veeravalli David A. Bader 《Journal of Parallel and Distributed Computing》2007
In this paper, we address the problem of multiple sequence alignment (MSA) for handling very large number of proteins sequences on mesh-based multiprocessor architectures. As the problem has been conclusively shown to be computationally complex, we employ divisible load paradigm (also, referred to as divisible load theory, DLT) to handle such large number of sequences. We design an efficient computational engine that is capable of conducting MSAs by exploiting the underlying parallelism embedded in the computational steps of multiple sequence algorithms. Specifically, we consider the standard Smith–Waterman (SW) algorithm in our implementation, however, our approach is by no means restrictive to SW class of algorithms alone. The treatment used in this paper is generic to a class of similar dynamic programming problems. Our approach is recursive in the sense that the quality of solutions can be refined continuously till an acceptable level of quality is achieved. After first phase of computation, we design a heuristic scheme that renders the final solution for MSA. We conduct rigorous simulation experiments using several hundreds of homologous protein sequences derived from the Rattus Norvegicus and Mus Musculus databases of olfactory receptors. We quantify the performance based on speed-up metric. We compare our algorithms to serial or single machine processing approaches. We testify our findings by comparing with conventional equal load partitioning (ELP) strategy that is commonly used in the parallel processing literature. Based on our extensive simulation study, we observe that DLT paradigm offers an excellent speed-up characteristics and provides avenues for its use in several other biological sequence processing related problem. This study is a first time attempt in using the DLT paradigm to devise efficient strategies to handle large scale multiple protein sequence alignment problem on mesh-based multiprocessor systems. 相似文献
153.
Mittal Vijay A.; Tessner Kevin D.; Trottman Hanan D.; Esterberg Michelle; Dhruv Shivali H.; Simeonova Diana I.; McMillan Amanda L.; Murphy Erin; Saczawa Mary E.; Walker Elaine F. 《Canadian Metallurgical Quarterly》2007,116(2):260
The link between movement abnormalities and psychotic disorders is presumed to reflect common neural mechanisms that influence both motor functions and vulnerability to psychosis. The prodromal period leading to psychotic disorders represents both a viable point for intervention and a developmental period that, if studied, could shed light on etiology; however, no published studies have examined the temporal progression of this link. A group with high levels of prodromal symptomatology (i.e., adolescents with schizotypal personality disorder [SPD]; n = 42) and both psychiatric controls (with other personality disorders or conduct disorder [OD]; n = 30) and nonpsychiatric controls ([NC]; n = 49) were recruited. Videotapes of structured psychiatric interviews were coded for movement abnormalities by raters blind to participants' diagnostic status, and follow-up assessments were conducted 1 year later. Controlling for psychotropic medications, the authors found that adolescents with SPD exhibited significantly more motor abnormalities in the face and upper body than did OD and NC controls. At baseline, movement abnormalities were positively correlated with the severity of positive, negative, and total prodromal symptoms. Within the SPD group, baseline movement abnormalities predicted symptom severity 1 year later. Movement abnormalities represent an early risk indicator that may be predictive of later symptom severity and potentially of psychosis onset. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
154.
Diana Borrego María Teresa Gómez-LópezAuthor VitaeRafael M. GascaAuthor Vitae 《Journal of Systems and Software》2013
Diagnosability analysis aims to determine whether observations available during the execution of a system are sufficient to precisely locate the source of a problem. Previous work deals with the diagnosability problem in contexts such as circuits and systems, but no with the adaptation of the diagnosability problem to business processes. In order to improve the diagnosability, a set of test points needs to be allocated. Therefore, the aim of this contribution is to determine a test-point allocation to obtain sufficient observable data in the dataflow to allow the discrimination of faults for a later diagnosis process. The allocation of test points depends on the strategies of the companies, for this reason we defined two possibilities: to improve the diagnosability of a business process for a fixed number of test points and the minimization of the number of test points for a given level of diagnosability. Both strategies have been implemented in the Test-Point Allocator tool in order to facilitate the integration of the test points in the business process model life cycle. Experimental results indicate that diagnosability of business processes can be improved by allocating test points in an acceptable time. 相似文献
155.
156.
Kevin A. Brown Richard Brooks Nicholas A. Warrior 《JOM Journal of the Minerals, Metals and Materials Society》2009,61(1):43-46
Thermoplastic composites (TPCs) are being given increased consideration for application in vehicle front-end structural crash
components. However, studies on the high strainrate behavior of TPCs have been relatively limited. In this study, the effect
of strain rate on the tensile properties of a woven fabric commingled E-glass/polypropylene thermoplastic composite was investigated
over a strain-rate range of 10−4 to 70 s−1. Quasi-static tests were conducted in an electromechanical universal test machine. A specially designed test rig in conjunction
with a falling weight drop tower was used for high strain-rate characterization. The experimental results show that the elastic
modulus, ultimate strength, and strain to failure increase with increasing strain rate. 相似文献
157.
158.
159.
María F. Gayol Diana O. Labuckas José Aparicio Juan C. Oberti Nelson R. Grosso Carlos A. Guzmán 《Journal of the American Oil Chemists' Society》2009,86(1):65-70
The objective of the research was to characterize the quality of damaged and undamaged jojoba seeds. The study was performed
on jojoba seeds grown in La Rioja, Argentina. Proximal composition, fatty acid composition, acid value, peroxide value, conjugated
dienes and trienes and protein electrophoresis profiles were determined in undamaged (JS) and damaged jojoba seeds (DJS).
The fat content (wax) was lower in DJS (39.11%) than in JS (50.82%). The values of acid, peroxide, conjugated dienes and trienes
were higher in DJS than in JS. No difference in fatty acid composition was observed between DJS and JS. The protein content
was not significantly different between JS and DJS. However, DJS had lower soluble protein values. In the electrophoresis
profiles, the band located at 50 kDa disappeared in DJS and the intensity of the band located at 25 kDa decreased. The deterioration
process in jojoba kernels significantly affects the chemical quality of their proteins and waxes. 相似文献
160.
AG Brooks F Borrego PE Posch A Patamawenu CJ Scorzelli M Ulbrecht EH Weiss JE Coligan 《Canadian Metallurgical Quarterly》1999,162(1):305-313
The CD94/NKG2 receptors expressed by subpopulations of NK cells and T cells have been implicated as receptors for a broad range of both classical and nonclassical HLA class I molecules. To examine the ligand specificity of CD94/NKG2 proteins, a soluble heterodimeric form of the receptor was produced and used in direct binding studies with cells expressing defined HLA class I/peptide complexes. We confirm that CD94/NKG2A specifically interacts with HLA-E and demonstrate that this interaction is dependent on the association of HLA-E with peptide. Moreover, no interaction between CD94/NKG2A and classical HLA class I molecules was observed, as assayed by direct binding of the soluble receptor or by functional assays using CD94/NKG2A+ NK cells. The role of the peptide associated with HLA-E in the interaction between HLA-E and CD94/NKG2A was also assessed. All class I leader sequence peptides tested bound to HLA-E and were recognized by CD94/NKG2A. However, amino acid variations in class I leader sequences affected the stability of HLA-E. Additionally, not all HLA-E/peptide complexes examined were recognized by CD94/NKG2A. Thus CD94/NKG2A recognition of HLA-E is controlled by peptide at two levels; first, peptide must stabilize HLA-E and promote cell surface expression, and second, the HLA-E/peptide complex must form the ligand for CD94/NKG2A. 相似文献