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排序方式: 共有125条查询结果,搜索用时 46 毫秒
71.
Dominik Szwajgier Adam Waśko Josef Zapp Zdzislaw Targoński 《Journal of the Institute of Brewing》2007,113(2):185-195
Ferulic acid (4‐hydroxy‐3‐methoxycinnamic acid), predominantly in ester form in arabinoxylan chains, is the main phenolic acid present in barley and malt. Only about 1% of the total ferulic acid in barley is present in the free form. A number of previous works concerned the contents of free and esterified ferulic acid in a broad range of popular beers, but there is little information about the possible composition of feruloylated oligosaccharides in beers. The aim of this preliminary work was to purify the feruloylated oligosaccharides from lager beers (by the means of preparative chromatography) followed by composition elucidation using TLC, HPLC with RI or UV detection and 1H‐NMR. Indeed, the qualitative analyses of isolated fractions from beer revealed that the fractions contained ferulic acid in the ester form (as proven after mild alkaline hydrolysis). It was also shown that molecular masses of oligosaccharides present in the purified beer fractions were similar to the masses of arabinose and xylooligosaccharides in the range of xylose to xylohexaose. Although a number of purified beer samples contained oligosaccharides of higher molecular masses, these were not further characterized. Taking under consideration the presented results, it can be concluded that beer can be a good source of feruloylated oligosaccharides, significant in the context of human health benefits. 相似文献
72.
Simunovic V Zapp J Rachid S Krug D Meiser P Müller R 《Chembiochem : a European journal of chemical biology》2006,7(8):1206-1220
Myxococcus xanthus DK1622 is shown to be a producer of myxovirescin (antibiotic TA) antibiotics. The myxovirescin biosynthetic gene cluster spans at least 21 open reading frames (ORFs) and covers a chromosomal region of approximately 83 kb. In silico analysis of myxovirescin ORFs in conjunction with genetic studies suggests the involvement of four type I polyketide synthases (PKSs; TaI, TaL, TaO, and TaP), one major hybrid PKS/NRPS (Ta-1), and a number of monofunctional enzymes similar to the ones involved in type II fatty-acid biosynthesis (FAB). Whereas deletion of either taI or taL causes a dramatic drop in myxovirescin production, deletion of both genes (DeltataIL) leads to the complete loss of myxovirescin production. These results suggest that both TaI and TaL PKSs might act in conjunction with a methyltransferase, reductases, and a monooxygenase to produce the 2-hydroxyvaleryl-S-ACP starter that is proposed to act as the biosynthetic primer in the initial condensation reaction with glycine. Polymerization of the remaining 11 acetates required for lactone formation is directed by 12 modules of Ta-1, TaO, and TaP megasynthetases. All modules, except for the first module of TaL, lack cognate acyltransferase (AT) domains. Furthermore, deletion of a discrete tandem AT-encoded by taV-blocks myxovirescin production; this suggests an "in trans" mode of action. To embellish the macrocycle with methyl and ethyl moieties, assembly of the myxovirescin scaffold is proposed to switch twice from PKS to 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA)-like biochemistry during biosynthesis. Disruption of the S-adenosylmethionine (SAM)-dependent methyltransferase, TaQ, shifts production toward two novel myxovirescin analogues, designated myxovirescin Q(a) and myxovirescin Q(c). NMR analysis of purified myxovirescin Q(a) revealed the loss of the methoxy carbon atom. This novel analogue lacks bioactivity against E. coli. 相似文献
73.
Weiss B Schaefer UF Zapp J Lamprecht A Stallmach A Lehr CM 《Journal of nanoscience and nanotechnology》2006,6(9-10):3048-3056
Nanoparticles have recently been demonstrated in a rat model to be a promising tool for targeting inflamed areas of the intestinal mucosa in inflammatory bowel diseases whilst concentrating anti-inflammatory drugs at their site of action. Still, however, this novel concept has to be proven in vivo in humans. As a first step biodegradable and biocompatible fluorescent nanoparticles were prepared and characterized to serve as markers for successful inflammation targeting in future clinical trials. To achieve stable fluorescence labelling, fluoresceinamine was covalently bound to poly(L-lactide-co-glycolide) (PLGA) as described by Horisawa et al. The modification rate of carboxyl-end groups of the PLGA chains determined by 1H NMR was 65%. From this modified polymer, nanoparticles (FA-PLGA nanoparticles) of approximately 270 nm size were prepared via nanoprecipitation. Apart from an initial burst effect, most of the label (> 88%) appeared to be strongly bound and was leaked only slowly from the particles. In contrast, we found an immediate leakage of encapsulated sodium fluorescein with nanoparticles prepared by a double emulsion method. In degradation experiments we studied and visualized the changes in morphology and elastic properties of the FA-PLGA nanoparticles within 15 weeks using atomic force microscopy. When FA-PLGA nanoparticles were applied on an in vitro model of the intestinal mucosa (Caco-2 cell culture), only minor amounts of their fluorescent degradation products (approximately 0.02% after 6 h) were transported. In a cytotoxicity study with Caco-2 cells, FA-PLGA nanoparticles yielded an IC50 value as for plain PLGA nanoparticles. In conclusion, the polymer modification method allows to prepare fluorescently labelled nanoparticles from a well-known biodegradable pharmaceutical polymer with sufficient stability to be monitored over a period of several days. Some initial leakage of fluorescence label appears to be unavoidable but negligible with respect to potential absorption and cytotoxicity when applied in vivo. 相似文献
74.
Scheibe Susanne; Bagby R. Michael; Miller Lesley S.; Dorian Barbara J. 《Canadian Metallurgical Quarterly》2001,13(3):369
In this study, the predictive capacity of the Minnesota Multiphasic Personality Inventory–2 Posttraumatic Stress Disorder–Keane (MMPI–2 PK) scale was examined in a sample of trauma victims who experienced a serious workplace-related accident and subsequent injury. In keeping with a number of previous investigations, the PK scale was largely ineffective in identifying posttraumatic stress disorder (PTSD) beyond overall symptom and functional severity. In contrast, sets of clinical and content scales proved to be significant predictors of PTSD. These findings suggest that the PK scale is not particularly useful in detecting PTSD in civilian trauma samples. Clinicians might be best advised to use the MMPI–2 clinical and content scales in their assessment of PTSD in civilian patients presenting with a history of trauma. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
75.
Julie Sarrand Laurie Baglione Dorian Parisis Muhammad Soyfoo 《International journal of molecular sciences》2022,23(10)
Sjögren’s syndrome (SS) is a chronic autoimmune disease that affects exocrine glands, primarily the salivary and lachrymal glands. It is characterized by lymphoplasmacytic infiltration of the glandular tissues, ultimately leading to their dysfunction and destruction. Besides classic dry eyes and dry mouth defined as sicca syndrome, patients affected by the disease also typically display symptoms such as fatigue, pain and in more than 50% of cases, systemic manifestations such as arthritis, interstitial lung involvement, neurological involvement and an increased risk of lymphoma. The pathophysiological mechanisms underlying SS still remain elusive. The crucial role of innate immunity has been advocated in recent years regarding the pathogenesis of pSS, especially in the initiation and progression toward autoimmunity. Alarmins are endogenous molecules that belong to the large family of damage associated molecular pattern (DAMP). Alarmins are rapidly released, ensuing cell injury and interacting with pattern recognition receptors (PRR) such as toll-like receptors (TLR) to recruit and activate cells of the innate immune system and to promote adaptive immunity responses. This review highlights the current knowledge of various alarmins and their role in the pathogenesis of pSS. 相似文献
76.
Suvrat Chowdhary Dr. Johann Moschner Dorian J. Mikolajczak Maximilian Becker Prof. Dr. Andreas F. Thünemann Dr. Claudia Kästner Damian Klemczak Anne-Katrin Stegemann Dr. Christoph Böttcher Prof. Dr. Pierangelo Metrangolo Dr. Roland R. Netz Dr. Beate Koksch 《Chembiochem : a European journal of chemical biology》2020,21(24):3544-3554
The hexapeptide hIAPP22–27 (NFGAIL) is known as a crucial amyloid core sequence of the human islet amyloid polypeptide (hIAPP) whose aggregates can be used to better understand the wild-type hIAPP′s toxicity to β-cell death. In amyloid research, the role of hydrophobic and aromatic-aromatic interactions as potential driving forces during the aggregation process is controversially discussed not only in case of NFGAIL, but also for amyloidogenic peptides in general. We have used halogenation of the aromatic residue as a strategy to modulate hydrophobic and aromatic-aromatic interactions and prepared a library of NFGAIL variants containing fluorinated and iodinated phenylalanine analogues. We used thioflavin T staining, transmission electron microscopy (TEM) and small-angle X-ray scattering (SAXS) to study the impact of side-chain halogenation on NFGAIL amyloid formation kinetics. Our data revealed a synergy between aggregation behavior and hydrophobicity of the phenylalanine residue. This study introduces systematic fluorination as a toolbox to further investigate the nature of the amyloid self-assembly process. 相似文献
77.
One option to transport hydrogen over longer distances in the future is via Liquid Organic Hydrogen Carriers (LOHC). They can store 6.2 wt% hydrogen by hydrogenation. The most promising LOHCs are toluene and dibenzyltoluene. However, for the dehydrogenation of the LOHCs – to release the hydrogen again – temperatures above 300 °C are needed, leading to a high energy demand. Therefore, a Life Cycle Assessment (LCA) and Life Cycle Costing are conducted. Both assessments concentrate on the whole life cycle rather than just direct emissions and investments. In total five different systems are analysed with the major comparison between conventional transport of hydrogen in a liquefied state of matter and LOHCs. Variations include electricity supply for liquefaction, heat supply for dehydrogenation and the actual LOHC compound. The results show that from an economic point of view transport via LOHCs is favourable while from an environmental point of view transport of liquid hydrogen is favourable. 相似文献
78.
Polysulfone composites were prepared by solution casting, using various types of treated carbon nanotubes (CNTs) at loadings of up to 5 wt%. The CNT types tested were: as‐received, acid treated, OCA surfactant, OCA functionalized and Poly(methyl methacrylate) functionalized nanotubes prepared using both as‐received and acid treated CNT. The treatment types investigated were selected based upon their solubility parameters and on the results of previous studies. The treated CNTs, CNT/solvent dispersions and the final composite samples were characterised using Fourier Transform Infrared Spectroscopy (FTIR), thermal analysis, Transmission Electron Microscopy (TEM), Ultraviolet‐Visible (UV‐vis) spectroscopy, optical microscopy, electrical conductivity and tensile testing. It was observed that the all the treatments studied improved the stability of CNT in the solvent. Of the CNT types studied, composites containing OCA functionalised CNT displayed the lowest percolation threshold (3 wt%) and highest mechanical performance. While the use of Hildebrand solubility parameters is useful in indentifying promising CNT treatments, their use can not fully predict CNT dispersion behaviour and composite performance. It is also critical to consider the influence of any treatments on CNT length and residual solvent levels. POLYM. COMPOS., 2011. © 2011 Society of Plastics Engineers 相似文献
79.
Fernando Alonso-Marroquín Álvaro Ramírez-Gómez Carlos González-Montellano Nigel Balaam Dorian A. H. Hanaor E. A. Flores-Johnson Yixiang Gan Shumiao Chen Luming Shen 《Granular Matter》2013,15(6):811-826
Responding to a lack in the literature, mechanical properties of polygonal wood particles are determined for use in a discrete element model (DEM) for flow analysis in silos, and some methods are proposed for determining such parameters. The parameters arrived at here have also formed part of the input to the SPOLY software, developed in-house to compute the DEM model with spheropolyhedron elements. The model is validated using a 2D physical model, where “prismatic” particles with polygonal cross sections are placed inside a silo with variable aperture and hopper angle. Validation includes comparison of flow-rates computed by SPOLY, displacement profiles, and clogging thresholds with experimental results. The good agreement that emerges will encourage future use of miniature triaxial tests, grain-surface profilometry, inclined slope tests, and numerical analysis of the intragranular stresses—toward a direct construction of the contact-deformation relations required in realistic DEM modelling of particle flow with angular-shaped particles. 相似文献
80.
Julie K. Furmick Dr. Ichiro Kaneko Angela N. Walsh Joanna Yang Jaskaran S. Bhogal Geoffrey M. Gray Juan C. Baso Drew O. Browder Jessica L. S. Prentice Luis A. Montano Chanh C. Huynh Lisa M. Marcus Dorian G. Tsosie Jungeun S. Kwon Alexis Quezada Nicole M. Reyes Brittney Lemming Puneet Saini Dr. Arjan van der Vaart Dr. Thomas L. Groy Dr. Pamela A. Marshall Dr. Peter W. Jurutka Dr. Carl E. Wagner 《ChemMedChem》2012,7(9):1510-1510