A microvalve for hybrid microfluidic systems

A hybrid valve for lab on chip applications is presented. The valve is assembled by bonding poly (methyl methacrylate), PMMA, and silicon-based elastomers. The process used to promote the hybrid bonding includes the deposition of an organosilane (TMSPM) on the thermoplastic polymer, PMMA to interface PMMA and elastomers. For this study, a membrane in ELASTOSIL^? is bonded in correspondence of the end of two microfluidic channels of a fabricated PMMA microfluidic chip. Prior the bonding, a plasma etching process has been used to remove the TMSPM in a confined circular area. This process made possible to bond selectively the edge of a membrane leaving free to move its central part. Actuating the membrane with an external positive pressure or vacuum is possible, respectively, to obstruct or to connect the microfluidic channels. The microvalve may be simply integrated in microfluidic devices and permits the control of microvolumes of fluid in processes such as transport, separation, and mixing. The deposition of the TMSPM, the bonding of the valve and its actuation has been characterized and tested. The flow rate control of liquids through the valve has been characterized. The results have been discussed and commented. The valve can stand up to 14 psi without showing leakages.     

<Emphasis Type="Italic">A Midsummer Night’s Dream</Emphasis> (with flying robots)

Seven flying robot “fairies” joined human actors in the Texas A&;M production of William Shakespeare’s A Midsummer Night’s Dream. The production was a collaboration between the departments of Computer Science and Engineering, Electrical and Computer Engineering, and Theater Arts. The collaboration was motivated by two assertions. First, that the performing arts have principles for creating believable agents that will transfer to robots. Second, the theater is a natural testbed for evaluating the response of untrained human groups (both actors and the audience) to robots interacting with humans in shared spaces, i.e., were believable agents created? The production used two types of unmanned aerial vehicles, an AirRobot 100-b quadrotor platform about the size of a large pizza pan, and six E-flite Blade MCX palm-sized toy helicopters. The robots were used as alter egos for fairies in the play; the robots did not replace any actors, instead they were paired with them. The insertion of robots into the production was not widely advertised so the audience was the typical theatergoing demographic, not one consisting of people solely interested technology. The use of radio-controlled unmanned aerial vehicles provides insights into what types of autonomy are needed to create appropriate affective interactions with untrained human groups. The observations from the four weeks of practice and eight performances contribute (1) a taxonomy and methods for creating affect exchanges between robots and untrained human groups, (2) the importance of improvisation within robot theater, (3) insights into how untrained human groups form expectations about robots, and (4) awareness of the importance of safety and reliability as a design constraint for public engagement with robot platforms. The taxonomy captures that apparent affect can be created without explicit affective behaviors by the robot, but requires talented actors to convey the situation or express reactions. The audience’s response to robot crashes was a function of whether they had the opportunity to observe how the actors reacted to robot crashes on stage, suggesting that pre-existing expectations must be taken into account in the design of autonomy. Furthermore, it appears that the public expect robots to be more reliable (an expectation of consumer product hardening) and safe (an expectation from product liability) than the current capabilities and this may be a major challenge or even legal barrier for introducing robots into shared public spaces. These contributions are expected to inform design strategies for increasing public engagement with robot platforms through affect, and shows the value of arts-based approaches to public encounters with robots both for generating design strategies and for evaluation.     

Supporting Different Dimensions of Adaptability in Workflow Modeling

This paper discusses the theme of workflow systemadaptability in relation to process modeling. Startingfrom a discussion on the role of formal constructs incooperation, the main claim is that adaptabilityinvolves different dimensions of process modeling.These dimensions concern the possibility to flexiblycombine a rich set of basic categories in order toobtain the most suitable language for modeling thetarget business process and the work practices aroundit; to take into account various levels of visibilityof the contexts of definition and use of a processmodel; and finally to allow for temporary as well aspermanent modifications of the process itself.Ariadne, a notation conceived for the above purpose,is illustrated by means of a working example.Moreover, the paper presents the main designprinciples governing Ariadne's implementation.     

High-Energy Physics on the Grid: the ATLAS and CMS Experience

In this paper we present the experience of the ATLAS and CMS High-Energy Physics (HEP) experiments at the Large Hadron Collider (LHC) with the LCG/EGEE Grid infrastructure. The activity developed around the following two main lines: large-scale physics and detector simulations and end-user analysis. The LCG/EGEE Grid infrastructure offers a large amount of computing and storage resources and is growing very rapidly. It provides the natural environment for large-scale physics and detector simulations. Also, the analysis of these detector simulation data (and in the near future of the reconstructed data from physics collisions) requires efficient end-users access to Grid resources. In this paper, the main findings and lessons learned in terms of performance, robustness and scalability of the whole system are discussed in detail.     

Performance evaluation of semantic registries: OWLJessKB and instanceStore

Service discovery is a critical task in distributed computing architectures for finding a particular service instance. Semantic annotations of services help to enrich the service discovery process. Semantic registries are an important component for the discovery of services and they allow for semantic interoperability through ontology-based query formulation and dynamic mapping of terminologies between system domains. This paper evaluates two semantic registries—OWLJessKB implementation and instanceStore—to determine the suitability of these with regards to the query response time and the overall scalability for use in mathematical services. Mathematical ontologies from the MONET project are used to undertake comparison. The results demonstrate that the performance of registries may be compared across two axes: (1) time to initialize (i.e. time to load an initial ontology into memory); (2) time to query (i.e. time to reason with an ontology loaded into memory).     

Treatment of acute lymphoblastic leukemia. 30 years' experience at St. Jude Children's Research Hospital

BACKGROUND: Therapy for childhood lymphoblastic leukemia has evolved during the past three decades, but key questions about what are the least toxic, most effective forms of treatment remain unanswered because of the lack of comprehensive follow-up information. METHODS: To assess long-term outcome in the series of clinical trials conducted at St. Jude Hospital, we compared the results of treatment typical of four eras: exploratory combination chemotherapy (era 1, 1962 to 1966; 91 patients), regimens for the control of meningeal leukemia (era 2, 1967 to 1979; 825 patients), limited intensification of therapy (era 3, 1979 to 1983; 428 patients), and extended intensification of therapy (era 4, 1984 to 1988; 358 patients). ("Intensification" refers to strategies of systemic chemotherapy that are more aggressive than conventional ones.) The major end points were survival and event-free survival; we also calculated the relative risk of treatment failure and the rate of relapse or death after treatment ended (post-treatment failure rate). RESULTS: The probability of event-free survival improved significantly in each successive era (P < 0.001 by the log-rank test), reaching 71 percent in era 4. There was a decrease of approximately 50 percent in the risk of treatment failure from one era to the next in each subgroup of patients defined according to different combinations of the leukocyte count, race, age, and sex. Leukemia appeared to be eradicated in patients who remained in complete remission for three years or more after treatment in era 4. The incidence of death due to nonleukemic causes remained 4 to 6 percent despite the trend toward more intensive treatment. An estimated 765 patients (45 percent) are long-term survivors; most of them (80 percent) have no health problems related to leukemia or its treatment. CONCLUSIONS: The development and successful application of preventive therapy for meningeal leukemia, followed by the intensification of systemic chemotherapy, has progressively improved the rate of cure of childhood lymphoblastic leukemia, with relatively few adverse sequelae.     

Multi-product economic lot scheduling problem with manufacturing and remanufacturing using a basic period policy

In this research we study the multi-product Economic Lot Scheduling Problem (ELSP) with manufacturing and remanufacturing opportunities. Manufacturing and remanufacturing operations are performed on the same production line. Both manufactured and remanufactured products have the same quality thus they fulfil the same demand stream. Tang and Teunter (2006) firstly studied this type of Economic Lot Scheduling Problem with Returns (ELSPR) and presented a complex algorithm for the optimal solution. More recently Teunter, Tang, and Kaparis (2009) proposed several heuristics to deal with the same problem using more computational efficient approaches. However, both studies have limited the attention to the common cycle policy with the assumption that a single (re)manufacturing lot is used for each item in each cycle. Relaxing the constraint of common cycle time and a single (re)manufacturing lot for each item in each cycle, we propose a simple, easy to implement algorithm, based on Segerstedt (1999), to solve the model using a basic period policy. Several numerical examples show the applicability of the algorithm and the cost savings.     

Is cheating a human function? The roles of presence,state hostility,and enjoyment in an unfair video game

In sports and board games, when an opponent cheats, the other players typically greet it with disdain, anger, and disengagement. However, work has yet to fully address the role of the computer cheating in video games. In this study, participants played either a cheating or a non-cheating version of a modified open-source tower-defense game. Results indicate that when a computer competitor cheats, players perceive the opponent as being more human. Cheating also increases player aggravation and presence, but does not affect enjoyment of the experience. Additionally, players that firmly believed that their opponent was controlled by the computer exhibited significantly less state hostility compared to players that were less certain of the nature of their competitor. Game designers can integrate subtle levels of cheating into computer opponents without any real negative responses from the players. The results indicate that minor levels of cheating might also increase player engagement with video games.     

A dynamic variational multiscale method for viscoelasticity using linear tetrahedral elements

In this article, we develop a dynamic version of the variational multiscale (D‐VMS) stabilization for nearly/fully incompressible solid dynamics simulations of viscoelastic materials. The constitutive models considered here are based on Prony series expansions, which are rather common in the practice of finite element simulations, especially in industrial/commercial applications. Our method is based on a mixed formulation, in which the momentum equation is complemented by a pressure equation in rate form. The unknown pressure, displacement, and velocity are approximated with piecewise linear, continuous finite element functions. To prevent spurious oscillations, the pressure equation is augmented with a stabilization operator specifically designed for viscoelastic problems, in that it depends on the viscoelastic dissipation. We demonstrate the robustness, stability, and accuracy properties of the proposed method with extensive numerical tests in the case of linear and finite deformations.