射流喷网非织造布的现状和发展方向

当人们想到揩布时,首先会想到射流喷网非织造布,这是该领域生产商最想听到的话.相对于射流喷网非织造布,虽然气流成网非织造布还占据一定的揩布市场,但通常是射流喷网非织造布价格更便宜,传统的气流成网非织造布无法与之相比.     

The Migration of Multi-tier E-commerce Applications to an Enterprise Java Environment

As technology evolves, many organizations face the problem of migrating legacy applications from one technology base to another. We report on a case study involving the migration of legacy code into the IBM® WebSphere® Commerce Suite product. Specifically, we focus on the problem of migrating applications that use traditional database access techniques to applications using the Enterprise JavaBean (EJB) programming model. Our results include a practical methodology that facilitates such migration, as well as a tool that supports this methodology. The tool has been released on IBM's alphaWorks site.     

VSculpt : a distributed virtual sculpting environment for collaborative design

A collaborative virtual sculpting system supports a team of geographically separated designers/engineers connected by networks to participate in designing three-dimensional (3D) virtual engineering tools or sculptures. It encourages international collaboration at a minimal cost. However, in order for the system to be useful, two factors need to be addressed: intuitiveness and real-time interaction. Although a lot of effort has been put into developing virtual sculpting environments, only limited work addresses collaborative virtual sculpting. This is because in order to support real-time collaborative virtual sculpting, many challenging issues need to be addressed. We propose a collaborative virtual sculpting framework, called VSculpt. Through adapting some techniques we developed earlier and integrating them with some techniques developed here, the proposed framework provides a real-time intuitive environment for collaborative design. In particular, it addresses issues on efficient rendering and transmission of deformable objects, intuitive object deformation using the CyberGlove and concurrent object deformation by multiple clients. We demonstrate and evaluate the performance of the proposed framework through a number of experiments.     

光电导及光反射法测量AlGaN薄膜的Al组分

ＡｌＧａＮ／ＧａＮ异质结兰光激光器和发光管近年来得到很大的发展．高速和高功率的ＡｌＧａＮ／ＧａＮ异质结场效应管（ＨＦＥＴ）的研究也得到很大的重视．ＡｌＧａＮ 薄层中的Ａｌ组分是决定此类器件的设计和性能的一个重要参量． 传统的测量组分的方法如ＸＰＳ和Ａｕｇｅｒ等方法需要大型的仪器,而且大多数方法是破坏性的,注意到ＡｌＧａＮ的禁带宽度Ｅｇ和Ａｌ组分有直接的关系,可以通过光学方法先测出Ｅｇ,用下式推算出Ａｌ的组分： Ｅｇ（ＡｌＧａＮ）＝ Ｅｇ（ＧａＮ）（１－ｘ）＋Ｅｇ（ＡｌＮ）ｘ－ｂｘ（１－ｘ）．其中ｘ是…     

The Molecular Mechanisms of Actions,Effects, and Clinical Implications of PARP Inhibitors in Epithelial Ovarian Cancers: A Systematic Review

Ovarian cancer is the most lethal gynecologic malignancy in the United States. Some patients affected by ovarian cancers often present genome instability with one or more of the defects in DNA repair pathways, particularly in homologous recombination (HR), which is strictly linked to mutations in breast cancer susceptibility gene 1 (BRCA 1) or breast cancer susceptibility gene 2 (BRCA 2). The treatment of ovarian cancer remains a challenge, and the majority of patients with advanced-stage ovarian cancers experience relapse and require additional treatment despite initial therapy, including optimal cytoreductive surgery (CRS) and platinum-based chemotherapy. Targeted therapy at DNA repair genes has become a unique strategy to combat homologous recombination-deficient (HRD) cancers in recent years. Poly (ADP-ribose) polymerase (PARP), a family of proteins, plays an important role in DNA damage repair, genome stability, and apoptosis of cancer cells, especially in HRD cancers. PARP inhibitors (PARPi) have been reported to be highly effective and low-toxicity drugs that will tremendously benefit patients with HRD (i.e., BRCA 1/2 mutated) epithelial ovarian cancer (EOC) by blocking the DNA repair pathways and inducing apoptosis of cancer cells. PARP inhibitors compete with NAD⁺ at the catalytic domain (CAT) of PARP to block PARP catalytic activity and the formation of PAR polymers. These effects compromise the cellular ability to overcome DNA SSB damage. The process of HR, an essential error-free pathway to repair DNA DSBs during cell replication, will be blocked in the condition of BRCA 1/2 mutations. The PARP-associated HR pathway can also be partially interrupted by using PARP inhibitors. Grossly, PARP inhibitors have demonstrated some therapeutic benefits in many randomized phase II and III trials when combined with the standard CRS for advanced EOCs. However, similar to other chemotherapy agents, PARP inhibitors have different clinical indications and toxicity profiles and also face drug resistance, which has become a major challenge. In high-grade epithelial ovarian cancers, the cancer cells under hypoxia- or drug-induced stress have the capacity to become polyploidy giant cancer cells (PGCCs), which can survive the attack of chemotherapeutic agents and start endoreplication. These stem-like, self-renewing PGCCs generate mutations to alter the expression/function of kinases, p53, and stem cell markers, and diploid daughter cells can exhibit drug resistance and facilitate tumor growth and metastasis. In this review, we discuss the underlying molecular mechanisms of PARP inhibitors and the results from the clinical studies that investigated the effects of the FDA-approved PARP inhibitors olaparib, rucaparib, and niraparib. We also review the current research progress on PARP inhibitors, their safety, and their combined usage with antiangiogenic agents. Nevertheless, many unknown aspects of PARP inhibitors, including detailed mechanisms of actions, along with the effectiveness and safety of the treatment of EOCs, warrant further investigation.     

Influences of Connecting Unit Architecture on the Performance of Tandem Organic Light‐Emitting Devices

The present work investigates the influence of the n‐type layer in the connecting unit on the performance of tandem organic light‐emitting devices (OLEDs). The n‐type layer is typically an organic electron‐transporting layer doped with reactive metals. By systematically varying the metal dopants and the electron‐transporting hosts, we have identified the important factors affecting the performance of the tandem OLEDs. Contrary to common belief, device characteristics were found to be insensitive to metal work functions, as supported by the ultraviolet photoemission spectroscopy results that the lowest unoccupied molecular orbitals of all metal‐doped n‐type layers studied here have similar energy levels. It suggests that the electron injection barriers from the connecting units are not sensitive to the metal dopant used. On the other hand, it was found that performance of the n‐type layers depends on their electrical conductivities which can be improved by using an electron‐transporting host with higher electron mobility. This effect is further modulated by the optical transparency of constituent organic layers. The efficiency of tandem OLEDs would decrease as the optical transmittance decreases.     

Update on Glycosphingolipids Abundance in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer. Low numbers of HCC patients being suitable for liver resection or transplantation and multidrug resistance development during pharmacotherapy leads to high death rates for HCC patients. Understanding the molecular mechanisms of HCC etiology may contribute to the development of novel therapeutic strategies for prevention and treatment of HCC. UDP-glucose ceramide glycosyltransferase (UGCG), a key enzyme in glycosphingolipid metabolism, generates glucosylceramide (GlcCer), which is the precursor for all glycosphingolipids (GSLs). Since UGCG gene expression is altered in 0.8% of HCC tumors, GSLs may play a role in cellular processes in liver cancer cells. Here, we discuss the current literature about GSLs and their abundance in normal liver cells, Gaucher disease and HCC. Furthermore, we review the involvement of UGCG/GlcCer in multidrug resistance development, globosides as a potential prognostic marker for HCC, gangliosides as a potential liver cancer stem cell marker, and the role of sulfatides in tumor metastasis. Only a limited number of molecular mechanisms executed by GSLs in HCC are known, which we summarize here briefly. Overall, the role GSLs play in HCC progression and their ability to serve as biomarkers or prognostic indicators for HCC, requires further investigation.     

Molecular design of nanohybrid gas separation membranes for optimal CO2 separation

Organic-inorganic materials comprising CO₂-philic components may yield superior CO₂ transport properties and good CO₂/H₂ gas selectivity. We report that a fine balance in size heterogeneity in the silicon-based structures is essential and a mixture of sizes up to 50 nm surrounded by 5–15 nm silicon-based nanostructures is the preferred inorganic phase morphology that yields optimal nanohybrid membranes. The combination of optimal synthesis conditions i.e. water/silicon ratio, condensation and ozone pre-treatment durations yields a nanohybrid membrane with a CO₂ permeability of 2000 Barrer while achieving a CO₂/H₂ selectivity of 11. The findings of this work are important for the design of gas separation membranes using green materials.