Computational homogenization of elasticity on a staggered grid

In this article, we propose to discretize the problem of linear elastic homogenization by finite differences on a staggered grid and introduce fast and robust solvers. Our method shares some properties with the FFT‐based homogenization technique of Moulinec and Suquet, which has received widespread attention recently because of its robustness and computational speed. These similarities include the use of FFT and the resulting performing solvers. The staggered grid discretization, however, offers three crucial improvements. Firstly, solutions obtained by our method are completely devoid of the spurious oscillations characterizing solutions obtained by Moulinec–Suquet's discretization. Secondly, the iteration numbers of our solvers are bounded independently of the grid size and the contrast. In particular, our solvers converge for three‐dimensional porous structures, which cannot be handled by Moulinec–Suquet's method. Thirdly, the finite difference discretization allows for algorithmic variants with lower memory consumption. More precisely, it is possible to reduce the memory consumption of the Moulinec–Suquet algorithms by 50%. We underline the effectiveness and the applicability of our methods by several numerical experiments of industrial scale. Copyright © 2015 John Wiley & Sons, Ltd.     

Long COVID: Association of Functional Autoantibodies against G-Protein-Coupled Receptors with an Impaired Retinal Microcirculation

Long COVID (LC) describes the clinical phenotype of symptoms after infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Diagnostic and therapeutic options are limited, as the pathomechanism of LC is elusive. As the number of acute SARS-CoV-2 infections was and is large, LC will be a challenge for the healthcare system. Previous studies revealed an impaired blood flow, the formation of microclots, and autoimmune mechanisms as potential factors in this complex interplay. Since functionally active autoantibodies against G-protein-coupled receptors (GPCR-AAbs) were observed in patients after SARS-CoV-2 infection, this study aimed to correlate the appearance of GPCR-AAbs with capillary microcirculation. The seropositivity of GPCR-AAbs was measured by an established cardiomyocyte bioassay in 42 patients with LC and 6 controls. Retinal microcirculation was measured by OCT–angiography and quantified as macula and peripapillary vessel density (VD) by the Erlangen-Angio Tool. A statistical analysis yielded impaired VD in patients with LC compared to the controls, which was accentuated in female persons. A significant decrease in macula and peripapillary VD for AAbs targeting adrenergic β2-receptor, MAS-receptor angiotensin-II-type-1 receptor, and adrenergic α1-receptor were observed. The present study might suggest that a seropositivity of GPCR-AAbs can be linked to an impaired retinal capillary microcirculation, potentially mirroring the systemic microcirculation with consecutive clinical symptoms.     

Serum Proteomics in Patients with Head and Neck Cancer: Peripheral Blood Immune Response to Treatment

In this real-world study, the aims were to prospectively evaluate the expression of inflammatory proteins in serum collected from head and neck cancer patients before and after treatment, and to assess whether there were differences in expression associated with treatment modalities. The mixed study cohort consisted of 180 patients with head and neck cancer. The most common tumor sites were the oropharynx (n = 81), the oral cavity (n = 53), and the larynx (n = 22). Blood tests for proteomics analysis were carried out before treatment, 7 weeks after the start of treatment, and 3 and 12 months after the termination of treatment. Sera were analyzed for 83 proteins using an immuno-oncology biomarker panel (Olink, Uppsala, Sweden). Patients were divided into four treatment groups: surgery alone (Surg group, n = 24), radiotherapy with or without surgery (RT group, n = 94), radiotherapy with concomitant cisplatin (CRT group, n = 47), and radiotherapy with concomitant targeted therapy (RT Cetux group, n = 15). For the overall cohort, the expression levels of 15 of the 83 proteins changed significantly between the pretreatment sample and the sample taken 7 weeks after the start of treatment. At 7 weeks after the start of treatment, 13 proteins showed lower expression in the CRT group compared to the RT group. The majority of the inflammatory proteins had returned to their pretreatment levels after 12 months. It was clearly demonstrated that cisplatin-based chemoradiation has immunological effects in patients with head and neck cancer. This analysis draws attention to several inflammatory proteins that are of interest for further studies.     

Managing incidents in a complex system: a railway case study

The authors of this paper review how complex entities, composed of many interdependent subsystems, such as international rail operators, can improve their ability to recover from incidents through the better management of key interfaces. The principles of Normal Accident Theory and resilience engineering are discussed, and the case study of the Eurostar incident of 18–19 December 2009 is considered in detail. Lessons learnt from resilience engineering are applied to the case study to extract recommendations by which incident management for open access international rail transport may be improved.     

Modelling corn production in China using AVHRR‐based vegetation health indices

Weather‐related crop losses have always been a concern for farmers, governments, traders and policy makers for the purpose of balanced food supplies, demands, trade, and distribution of aid to nations in need. Therefore, early crop loss assessment in response to weather fluctuations is an important issue. This paper discusses the utility of Advanced Very High Resolution Radiometer (AVHRR)‐based vegetation health indices as a proxy for modelling corn yield and for early warning of drought‐related losses of agricultural production in China. The indices were tested in Jilin province on corn yield during 1982–2001 using correlation and regression analysis. A strong correlation between corn yield and the vegetation health indices were found during the critical period of corn growth, which starts 2–3 weeks before and 2–3 weeks after corn tassel. Following the results of correlation analysis, several regression equations were constructed where vegetation health indices were used as independent variables. The estimates of corn yield can be carried out well in advance of harvest and the errors of the estimates are 7–10%. The errors become smaller when the estimations are related to losses in corn yield due to drought.     

A case study in the mechanical verification of fault tolerance

To date, there is little evidence that modular reasoning about fault-tolerant systems can simplify the verification process in practice. This question is studied using a prominent example from the fault tolerance literature: the problem of reliable broadcast in point-to-point networks subject to crash failures of processes. The experiences from this case study show how modular specification techniques and rigorous proof re-use can indeed help in such undertakings.