Substance P,A Promising Therapeutic Target in Musculoskeletal Disorders

A large number of studies have focused on the role of substance P (SP) and the neurokinin-1 receptor (NK1R) in the pathogenesis of a variety of medical conditions. This review provides an overview of the role of the SP-NK1R pathway in the pathogenesis of musculoskeletal disorders and the evidence for its role as a therapeutic target for these disorders, which are major public health problems in most countries. To summarize, the brief involvement of SP may affect tendon healing in an acute injury setting. SP combined with an adequate conjugate can be a regenerative therapeutic option in osteoarthritis. The NK1R antagonist is a promising agent for tendinopathy, rheumatoid arthritis, and osteoarthritis. Research on the SP-NK1R pathway will be helpful for developing novel drugs for osteoporosis.     

Estrogen Receptors Mediated Negative Effects of Estrogens and Xenoestrogens in Teleost Fishes—Review

Estrogen receptors (ERs) play a key role in many biochemical and physiological processes, that are involved in maintaining organism homeostasis. At the most basic level, they can be divided into nuclear estrogen receptors and membrane estrogen receptors that imply their effect in two ways: slower genomic, and faster non-genomic. In these ways, estrogens and xenoestrogens can negatively affect animal health and welfare. Most of the available literature focuses on human and mammalian physiology, and clearly, we can observe a need for further research focusing on complex mutual interactions between different estrogens and xenoestrogens in aquatic animals, primarily fishes. Understanding the mechanisms of action of estrogenic compounds on the ERs in fishes and their negative consequences, may improve efforts in environmental protection of these animals and their environment and benefit society in return. In this review, we have summarized the ER-mediated effects of xenoestrogens and estrogens on teleost fishes metabolism, their carcinogenic potential, immune, circulatory, and reproductive systems.     

融合短语结构的多通道老挝语名词短语识别方法

名词短语的识别对句法分析等自然语言处理任务有着基础性的意义。目前,老挝语名词短语识别研究仍处于起步阶段,相较于其他语言,老挝语名词短语识别存在边界模糊、界定描述模糊、语料有限、句式过长等问题。针对以上问题,该文研究了老挝语名词短语的结构,并构建了融合其短语结构的多通道老挝语名词短语模型。模型通过将字符、词和词性特征组合形成不同的输入通道,使用多个BiLSTM网络从不同的方面提取更多隐藏信息,同时改善低资源语料存在大量未登录名词短语的问题。此外,由于老挝语句式过长,模型引入Attention机制,增加重要特征的权重,有效减少了无用信息的干扰。实验结果表明,该模型在有限标注语料下F₁值达到85.25%,优于其他模型方法。     

A novel reversible data hiding scheme with two-dimensional histogram shifting mechanism

Multimedia Tools and Applications - In this paper, we propose a novel reversible data hiding technique based on two-dimensional histogram shifting for quantized discrete cosine transformation...     

Experimental and Modeling Studies on the Chemical Vapor Infiltration with Respect to the Effects of Thermal Gradient and Other Operating Parameters

Effects of operating parameters in the thermal gradient chemical vapor infiltration of propane such as thermal gradient, diffusion, infiltrations time, and concentration of propane were studied by focusing on the visualizations of the intrinsic effects of these parameters. A uniform deposition in the preform was obtained with a gradually increasing temperature along the gas flow. The uniformity of deposition through the preform got improved with increasing deposition time. Results of numerical modeling estimated the experimental data very well when the pre-exponential factor of the overall rate of carbon deposition from propane reported by Vaidyaraman[1] was multiplied by 4. The average density of a preform increased by about 3 times from 0.38 to 1.15 g/cm3 after 60 hr deposition with a thermal gradient under the conditions of 3% propane in nitrogen and 840 to 900 ℃.     

加热面朝下的池沸腾汽泡动态行为研究

基于Matlab软件开发了自动识别气液两相流界面程序,程序可获得气液界面变化、汽膜厚度、汽膜脱离周期和汽膜法向速度等特征。利用该程序对沟槽结构加热表面朝下布置时,在不同倾角、不同热流密度下的汽泡动态数据进行了处理和分析。结果表明：加热表面朝下发生核态沸腾时,汽膜厚度随热流密度的增大而增大,汽泡脱离周期随热流密度的增大先减小,而后维持在一稳定值;汽膜脱离周期随倾角的增大而减小,倾角为5°时的汽膜脱离周期稳定在0.27 s左右。当发生沸腾危机时,汽膜厚度迅速减小,这可作为动态监测加热表面沸腾状态的依据。     

北京谱仪漂移室电子学系统电磁干扰问题的研究

介绍了北京仪漂移室电子学系统电磁干扰问题,阐述了如何根据造成电磁干扰的三要素分析与排除干扰的方法。     

Effect of Ni Addition on the Morphology and Microstructure of Both Conventional Cast and Melt-Spun of Al–Si–Fe–Nb (at wt%) Alloy

Metals and Materials International - In this project the morphology and microstructure of both conventional cast and melt spun of Al–20Si–9Fe–1.2Nb and...     

Textural development of sugar beet bagasse activated with ZnCl2

In this study, activated carbons were prepared from sugar beet bagasse, which is side product and waste in sugar plants, by chemical activation with ZnCl2. Influence of activation temperature was investigated on to pore structure. ZnCl2/sugar beet bagasse ratio (impregnation ratio) was selected as 1:1. The impregnated sample was raised to the activation temperature under N(2) (100ml/min) atmosphere with 10 degrees C/min heating rate and hold at this temperature for 1h. The activation temperature was varied over the temperature range of 400-900 degrees C. BET surface area values were determined in the range of 832-1697 m(2)/g. Under the experimental conditions, 500 degrees C was found to be the optimal condition for producing high surface area carbons with ZnCl2 activation. Sugar beet bagasse was suitable for preparation of activated carbon with essentially microporous structure. Activated carbon ash content was found in the range of 1.2-2.7 (%w/w d.b.). Activated carbon samples and raw material were characterized by XRD, FT-IR, DTA and TGA.