Estrogen, the ovary, and neutotransmitters: factors associated with aging

Our studies in the C57BL/6J mouse have been designed to examine the interactions of aging and the ovary, and their mutual effects on neuroendocrine function. In the pituitary, ovarian status and not age determines responsiveness to gonadotropin hormone releasing hormone (GnRH), but estrogen (E2) is an important mediator in CNS changes, and removal of the ovary (OVX) is deleterious to the neuroendocrine hypothalamus. OVX for just six days in young animals results in synaptic loss between noradrenergic terminals and gonadotropin hormone releasing hormone (GnRH) neurons. Long-term OVX, hypothesized to protect against neuroendocrine aging, fails to guard against any studied age-related changes. Some age-related changes occur as early as midlife. Although neuron number remains constant at middle age, opiatergic neurons undergo significant functional changes by producing opiate antagonist peptides. This change appears to be caused by alterations in the prohormone convertases, which cleave propeptide to peptide. Altered peptides may trigger the loss of reproductive capacity. The midlife shift in opiate peptide production is a component of natural developmental processes that begin in the neonate and continue through old age. In the cholinergic system, E2 mediates numbers of cholinergic receptors, cholinergic neurons, and cholinergic-modulated memory systems in both young and old animals. Regardless of age, ovarian steroids, if present at physiologic levels, are beneficial to the neuroendocrine CNS, and long-term deprivation from ovarian-produced factors is deleterious in the systems we have examined. Our studies have shown that deprivation from ovarian steroid hormones in the female appears to be a major factor in the health of the CNS and in events associated with aging.     

Knowing what to remember and forget: a developmental study of cue memory in intentional forgetting

These experiments are the first to investigate children's encoding and use of information about a memory cue in Bjork's (1972) intentional forgetting task. In Experiment 1, children in Grades 2, 4, and 6 and college students were given cues to either remember or forget after the presentation of each picture. Recall and recognition tests of pictures and cues followed. The procedure in Experiment 2 was identical to that in Experiment 1 except that the list of presentation pictures was altered for some children (Grades 3 and 4) and adolescents (Grades 8 and 9) so that remember and forget cues were associated with particular taxonomic categories. In Experiment 3, the testing component was modified so that children (Grades 2, 3, and 4) and college students were asked to recall only the cue associated with each picture. The results indicated that (1) children as young as second graders encode the cue associated with each picture, although to a lesser extent than do college students, (2) much improvement in intentional forgetting is still occurring during adolescence, (3) only adults adequately cluster their recall by cue, (4) associating remember and forget cues with items from different categories does not increase the differentiation between cues, and (5) eliminating picture recall and recognition has minimal effects on the magnitude of cue judgments. These results suggest that children's difficulties on intentional forgetting tasks stem, at least in part, from their poorer encoding of information about whether an item should be remembered or forgotten.     

Voronoi diagrams with barriers and on polyhedra for minimal path planning

Two generalizations of the Voronoi diagram in two dimensions (E²) are presented in this paper. The first allows impenetrable barriers that the shortest path must go around. The barriers are straight line segments that may be combined into polygons and even mazes. Each region of the diagram delimits a set of points that have not only the same closest existing point, but have the same topology of shortest path. The edges of this diagram, which has linear complexity in the number of input points and barrier lines, may be hyperbolic sections as well as straight lines. The second construction considers the Voronoi diagram on the surface of a convex polyhedron, given a set of fixed source points on it. Each face is partitioned into regions, such that the shortest path to any goal point in a given region from the closest fixed source point travels over the same sequence of faces to the same closest point.     

Facilitation using personal associations in a lexical decision task.

Experimenters using the lexical decision task have reported that the processing of a word target is facilitated by the prior processing of a related word prime. Three experiments with 60 university students are reported that generalize this phenomenon to personal associative structures between randomly selected items. The magnitude of the effect from these personal associations was contrasted with the effect obtained from using the more usual high-frequency word pairs associated in a normative manner. There was no difference between the facilitation obtained for common or personal associates, regardless of whether testing was immediate or delayed. It is concluded that the structural/processing characteristics that cause the phenomenon can validly be assumed to be general throughout memory. (French abstract) (15 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Spontaneous formation of nanoparticle stripe patterns through dewetting

Significant advancement has been made in nanoparticle research, with synthetic techniques extending over a wide range of materials with good control over particle size and shape. A grand challenge is assembling and positioning the nanoparticles in desired locations to construct complex, higher-order functional structures. Controlled positioning of nanoparticles has been achieved in pre-defined templates fabricated by top-down approaches. A self-assembly method, however, is highly desirable because of its simplicity and compatibility with heterogeneous integration processes. Here we report on the spontaneous formation of ordered gold and silver nanoparticle stripe patterns on dewetting a dilute film of polymer-coated nanoparticles floating on a water surface. Well-aligned stripe patterns with tunable orientation, thickness and periodicity at the micrometre scale were obtained by transferring nanoparticles from a floating film onto a substrate in a dip-coating fashion. This facile technique opens up a new avenue for lithography-free patterning of nanoparticle arrays for various applications including, for example, multiplexed surface-enhanced Raman substrates and templated fabrication of higher-order nanostructures.     

Mineral matter effects on the rapid pyrolysis and hydropyrolysis of a bituminous coal: 2. Effects of yields of C3-C8 hydrocarbons

Effects of minerals on yields of C₃-C₈ volatiles from rapid pyrolysis of a Pittsburgh Seam bituminous coal were investigated. Whole, demineralized, and mineral-treated samples of pulverized coal were heated in 101 kPa He or 6.99 MPaH₂ at 1000 K s⁻¹ to temperatures of up to 1300 K. Yields of C₃, C₄–C₆, and C₆–C₈ hydrocarbon gases were determined as a function of time-temperature history. Calcium minerals decrease yields of all three fractions in pyrolysis under He atmosphere but have little effect on hydropyrolysis. Kaolinite reduces yields in pyrolysis, but increases them in hydropyrolysis. Other minerals, notably FeSO₄, have varying effects on product yields depending on run conditions.     

Trends in digital communication by wire

The introduction and rapid spread of pulse code modulation must be examined in the framework of overall capability, efficiency, and cost. However, apart from television, the only field of application that can presently justify a massive investment in a new transmission system is telephony, because it represents the dominant communication market. Other communication services?such as data and facsimile transmission, telegraphy, broadcast sound, and closed-circuit television?must in general travel as passengers on telephony networks if they are to be economically feasible. Hence, the most fruitful approach to an examination of digital communication is to begin by studying PCM telephony and then to see how other services can be coordinated with it.     

Mantissa-function generator

A function generator for providing, in analogue, the mantissa of the logarithm of two numbers, given the logarithm of each, may be realised by the conductance of the series combination of a resistor and a semiconductor diode. Its application to a logarithmic digital/analogue convertor for serial inputs is described.     

Bilateral nephrectomy for uncontrollable nephrotic syndrome in primary amyloidosis, with subsequent improvement in hepatic function

Older radiation detection equipment used in Health Physics operations suffers from unreliable and outdated electronics, even when the radiation detectors, shielding, and mechanical components are still serviceable. Upgrading these systems through relatively simple interfaces to modern personal computers can provide a cost-effective solution to extend the life of these systems and provide state-of-the-art options for computer control and automation. This paper outlines the basic needs and requirements for this type of upgrade and describes three projects at University of Missouri--Columbia that have used this approach.