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41.
Daniel H. Mendelsohn Katja Schnabel Andreas Mamilos Samuel Sossalla Steffen Pabel Georg Daniel Duerr Karsten Keller Volker H. Schmitt Friedrich Barsch Nike Walter Ronald Man Yeung Wong Thaqif El Khassawna Tanja Niedermair Volker Alt Markus Rupp Christoph Brochhausen 《International journal of molecular sciences》2022,23(9)
Mitochondria play a crucial role in cell physiology and pathophysiology. In this context, mitochondrial dynamics and, subsequently, mitochondrial ultrastructure have increasingly become hot topics in modern research, with a focus on mitochondrial fission and fusion. Thus, the dynamics of mitochondria in several diseases have been intensively investigated, especially with a view to developing new promising treatment options. However, the majority of recent studies are performed in highly energy-dependent tissues, such as cardiac, hepatic, and neuronal tissues. In contrast, publications on mitochondrial dynamics from the orthopedic or trauma fields are quite rare, even if there are common cellular mechanisms in cardiovascular and bone tissue, especially regarding bone infection. The present report summarizes the spectrum of mitochondrial alterations in the cardiovascular system and compares it to the state of knowledge in the musculoskeletal system. The present paper summarizes recent knowledge regarding mitochondrial dynamics and gives a short, but not exhaustive, overview of its regulation via fission and fusion. Furthermore, the article highlights hypoxia and its accompanying increased mitochondrial fission as a possible link between cardiac ischemia and inflammatory diseases of the bone, such as osteomyelitis. This opens new innovative perspectives not only for the understanding of cellular pathomechanisms in osteomyelitis but also for potential new treatment options. 相似文献
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PROven(R)系统的开发为了减少焦炉的排放,过去已进行了多种技术的开发.但是从焦炉炉门、装料孔边缘等处逸散物的减少,已受到工艺技术的制约.一个基本的制约因素是,在集气总管内的压力和联接到总管的所有碳化室内的压力之间有着密不可分的关系. 相似文献
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Prof. Dr. Andreas Leson Gregor Englberger Daniel Hammer Stefan Makowski Carl‐Friedrich Meyer Michael Leonhard Hans‐Joachim Scheibe Volker Weihnacht 《真空研究与实践》2015,27(4):24-28
Diamond‐like carbon thin films enhance efficiency — laser arc deposition of ta‐C Rising prices for fossil fuels as well as the increasing effects of the climate change due to the emission of greenhouse gases reveal the necessity of saving energy. Low friction coatings have an enormous potential in saving energy. Carbon based coatings — named as DLC coatings — are especially well suited for low friction coatings. In particular hydrogen‐free tetrahedral amorphous carbon (ta‐C) coatings are of great interest due to their extraordinary low wear properties. In addition they show excellent low friction properties and especially in combination with specific lubricants the so‐called super low friction effect. For the deposition of ta‐C coatings PVD methods have to be applied instead of CVD methods as it is the case for conventional DLC coatings. We have developed a deposition method which is based on a pulsed arc steered by a laser (Laser‐Arc). This allows us to use large cathodes resulting in a high long‐term stability. Furthermore, the carbon plasma source can be combined with a filtering unit removing almost all droplets and particles, which usually are characteristic for an arc process. The resulting Laser‐Arc source allows for the deposition of smooth and virtually defect‐free ta‐C coatings with a competitive deposition rate. 相似文献
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Jürgen Allwohn Martin Brumm Gernot Frenking Matthias Hornivius Werner Massa Friedrich W. Steubert Sigrid Wocadlo 《Advanced Synthesis \u0026amp; Catalysis》1993,335(6):503-514
Synthesis and Conformational Analysis of Pyranophanones and Pyrylophanium Compounds with Intraannular Substituents The synthesis of [3.3]dithiapyranophanone 6 and 11 is accomplished by use of the two-components-dilution-principle. Pyrolysis of their bis(sulfones) 7 and 12 gives the [2.2]pyranophanones 8 , 9 and 13 . Under preservation of conformation the intraannular carbonyl-function is used for the synthesis of methylpyranophanoles 14 , 16 and 17 . The synthesis of pyrylophanium compounds 15 and 18 is possible by elimination in trifluoroacetic acid. 6 exhibits anti-conformation within its crystal-structure and like 7 reveals temperature-dependent behavior in solution. Using 6 as an example, a combination of 13C-NMR-spectroscopy, forcefield-calculation and computer-simulation is applied for the first time to give evidence for molecular-dynamic processes of cyclophanes. 8 and 9 are the syn- and anti-conformers of the desired product, as shown by X-ray structural analysis. 13 reveals anti-conformation within its crystal structure as well as in solution. The conformational analysis of other new phanes described here is based on the 1H-NMR-spectra of these pyrolysis products. As expected the intraannular substituents of Pyrylophanium-lons 15 and 18 show the characteristic upfield-shift within their 1H-NMR-spectra. 相似文献
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Elke Diekmann K. Friedrich Hans-Günther Fritz 《Advanced Synthesis \u0026amp; Catalysis》1993,335(5):415-424
Dideoxy Ribonucleosides by Fusion Method The dideoxy nucleosides 2 , 4 and 6 are synthesized from the 1-O-acetyl-2,3-dideoxyribose derivatives 1 , 3 and 5 by fusion with chlorinated purines and other nitrogen heterocycles at 110–120°C without added catalyst. The 1H-NMR and 13C-NMR spectra of the compounds are given. 相似文献
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