国有企业计算机网络管理

本论文在简单了解了计算机网络的相关内容后,对国有企业的计算机网络进行了简单的介绍,并举例说明了某国有企业的网络管理结构及功能。     

Macrophage Membrane-Coated Nanoparticles Sensitize Glioblastoma to Radiation by Suppressing Proneural–Mesenchymal Transformation in Glioma Stem Cells

Radiotherapy is identified as a crucial treatment for patients with glioblastoma, but recurrence is inevitable. The efficacy of radiotherapy is severely hampered partially due to the tumor evolution. Growing evidence suggests that proneural glioma stem cells can acquire mesenchymal features coupled with increased radioresistance. Thus, a better understanding of mechanisms underlying tumor subclonal evolution may develop new strategies. Herein, data highlighting a positive correlation between the accumulation of macrophage in the glioblastoma microenvironment after irradiation and mesenchymal transdifferentiation in glioblastoma are presented. Mechanistically, elevated production of inflammatory cytokines released by macrophages promotes mesenchymal transition in an NF-κB-dependent manner. Hence, rationally designed macrophage membrane-coated porous mesoporous silica nanoparticles (MMNs) in which therapeutic anti-NF-κB peptides are loaded for enhancing radiotherapy of glioblastoma are constructed. The combination of MMNs and fractionated irradiation results in the blockage of tumor evolution and therapy resistance in glioblastoma-bearing mice. Intriguingly, the macrophage invasion across the blood-brain barrier is inhibited competitively by MMNs, suggesting that these nanoparticles can fundamentally halt the evolution of radioresistant clones. Taken together, the biomimetic MMNs represent a promising strategy that prevents mesenchymal transition and improves therapeutic response to irradiation as well as overall survival in patients with glioblastoma.     

Decomposed-distance weighted optimal transport for unsupervised domain adaptation

Applied Intelligence - Unsupervised Domain Adaptation (UDA) aims to transfer knowledge from a label-rich source domain to an unlabeled target domain with a different but related distribution....     

Biomedical applications of mRNA nanomedicine

As an attractive alternative to plasmid DNA, messenger RNA (mRNA) has recently emerged as a promising class of nucleic acid therapeutics for biomedical applications. Advances in addressing the inherent shortcomings of mRNA and in the development of nanoparticle-based delivery systems have prompted the development and clinical translation of mRNA-based medicines. In this review, we discuss the chemical modification strategies of mRNA to improve its stability, minimize immune responses, and enhance translational efficacy. We also highlight recent progress in nanoparticle-based mRNA delivery. Considerable attention is given to the increasingly widespread applications of mRNA nanomedicine in the biomedical fields of vaccination, protein-replacement therapy, gene editing, and cellular reprogramming and engineering.     

基于CORBA和TLl的STP网元集中管理系统实现

设计了STP网元集中管理系统,阐述了该系统的体系结构和各模块的功能以及各模块间的通信方式.通过使用CORBA构建技术、IDL接口描述语言以及文本描述语言TLl,使得系统具有灵活性、可维护性和可扩展性的特点.该系统的实现,使得对信令网中的STP设备进行集中管理和统一维护成为可能,为进一步对信令网的检测和历史数据的采集分析提供了基础.     

A hybrid data-fusion system using modal data and probabilistic neural network for damage detection

This paper addresses a novel hybrid data-fusion system for damage detection by integrating the data fusion technique, probabilistic neural network (PNN) models and measured modal data. The hybrid system proposed consists of three models, i.e. a feature-level fusion model, a decision-level fusion model and a single PNN classifier model without data fusion. Underlying this system is the idea that we can choose any of these models for damage detection under different circumstances, i.e. the feature-level model is preferable to other models when enormous data are made available through multi-sensors, whereas the confidence level for each of multi-sensors must be determined (as a prerequisite) before the adoption of the decision-level model, and lastly, the single model is applicable only when data collected is somehow limited as in the cases when few sensors have been installed or are known to be functioning properly. The hybrid system is suitable for damage detection and identification of a complex structure, especially when a huge volume of measured data, often with uncertainties, are involved, such as the data available from a large-scale structural health monitoring system. The numerical simulations conducted by applying the proposed system to detect both single- and multi-damage patterns of a 7-storey steel frame show that the hybrid data-fusion system cannot only reliably identify damage with different noise levels, but also have excellent anti-noise capability and robustness.     

Construction of 1-Resilient Boolean Functions with Optimal Algebraic Immunity and Good Nonlinearity

This paper presents a construction for a class of 1-resilient functions with optimal algebraic immunity on an even number of variables. The construction is based on the concatenation of two balanced functions in associative classes. For some n, a part of 1-resilient functions with maximum algebraic immunity constructed in the paper can achieve almost optimal nonlinearity. Apart from their high nonlinearity, the functions reach Siegenthaler's upper bound of algebraic degree. Also a class of 1-resilient functions on any number n > 2 of variables with at least sub-optimal algebraic immunity is provided.