A Geometrical Analysis of the Layout of Acaya, Italy

The analysis of the urban fabric contained within the city walls of the town of Acaya, made possible by a new integrated survey involving manual, topographical, photogrammetric and 3D laserscan techniques, has cast doubts on the conventional attribution of the city layout to Gian Giacomo dell??Acaya. A rectangular layout consisting of six blocks divided by six longitudinal streets and three lateral streets is indicative of a medieval date. The geometrical analysis shows how the site of the ancient town of Salappya was transformed by Charles I d??Anjou in 1273, renaming it Segine, and how, in about 1500, Alfonso dell??Acaya enlarged the city and its walls according to the same proportional criteria. In 1536 Gian Giacomo dell??Acaya succeeded his father as Baron, redesigning the city walls in order to make them suitable lines of defense against firearms, renaming the city Acaya.     

Biofunctional Silk/Neuron Interfaces

Silk fibroin (SF) is a biocompatible and slowly biodegradable material with excellent mechanical properties and huge potential for use as biofunctional interface in electronic devices that aim to stimulate and control neural network activity and peripheral nerve repair. It is shown that SF films act as material interfaces that support the adherence and neurite outgrowth of dorsal root ganglion (DRG) neurons and preserve neuronal functions. Silk films preserve the capability of neuronal cells to fire and DRG neurons on silk films retain the intracellular free Ca²⁺ concentration ([Ca²⁺]_i) response to capsaicin, a typical noxious stimulus for this neuronal culture model. It is also demonstrated that nerve growth factor (NGF)‐functionalized silk films promote neurite outgrowth and modulate functional properties of DRG neurons. The results show that silk preserves DRG neuronal physiology and is a promising biomaterial platform for the future development of devices with goals including functional recovery of injured neurons, neurite functional outgrowth in vitro, or functional electrostimulation in vivo.     

Results of Measuring the Influence of Casimir Energy on Superconducting Phase Transitions

The ALADIN experiment aims at observing how the critical magnetic field of a superconducting aluminum film is modified, when it constitutes one of the reflecting surfaces of a Casimir cavity. If successful, such an observation would reveal the influence of vacuum energy on the superconducting phase transition. In this paper, a rigorous analysis of experimental data is reported, the results are discussed and compared with theoretical predictions based on Lifshitz theory of dispersion forces, and the BCS formula for the optical conductivity of superconductors. Thanks to this rigorous analysis, it can now be asserted that in the region of energy where it is expected that Casimir energy is comparable with condensation energy and the deviations of critical field from BCS formula to be not negligible, an anomalous behavior is found.     

Use of 24-bit false-color imagery to enhance visualization of multiparameter MR images

Biomedical image analysis workstations can be linked to 3D data-oriented devices for a new approach to image manipulation in biology and medicine. Stereo monitors allow an intuitive approach to medical diagnosis. The use of 3D head-tracking devices allows a more compelling 3D illusion to be generated. A stylus can be used as an electronic knife for dissecting a 3D data set; furthermore, other 3D sensors are available for tracking operator arm movements. The overall character of this work is firmly application oriented, in order to provide concrete operational tools to the medical user. Such tools range from diagnostic up to therapeutic and robotized use of bioimages.     

No Stress! Relax! Mechanisms Governing Growth and Shape in Plant Cells

The mechanisms through which plant cells control growth and shape are the result of the coordinated action of many events, notably cell wall stress relaxation and turgor-driven expansion. The scalar nature of turgor pressure would drive plant cells to assume spherical shapes; however, this is not the case, as plant cells show an amazing variety of morphologies. Plant cell walls are dynamic structures that can display alterations in matrix polysaccharide composition and concentration, which ultimately affect the wall deformation rate. The wide varieties of plant cell shapes, spanning from elongated cylinders (as pollen tubes) and jigsaw puzzle-like epidermal cells, to very long fibres and branched stellate leaf trichomes, can be understood if the underlying mechanisms regulating wall biosynthesis and cytoskeletal dynamics are addressed. This review aims at gathering the available knowledge on the fundamental mechanisms regulating expansion, growth and shape in plant cells by putting a special emphasis on the cell wall-cytoskeleton system continuum. In particular, we discuss from a molecular point of view the growth mechanisms characterizing cell types with strikingly different geometries and describe their relationship with primary walls. The purpose, here, is to provide the reader with a comprehensive overview of the multitude of events through which plant cells manage to expand and control their final shapes.     

Integrated design of a linear/neuro-adaptive controller in the presence of norm-bounded uncertainties

Adaptive neural controllers are often criticised for the lack of clear and easy design methodologies that relate adaptive neural network (NN) design parameters to performance requirements. This study proposes a methodology for the design of an integrated linear-adaptive model reference controller that guarantees component-wise boundedness of the tracking error within an a priori specified compact domain. The approach is based on the design of a robust invariant ellipsoidal set where both the NN reconstruction error and the neuro-adaptive control are considered as bounded persistent uncertainties. We show that all the performance and control requirements for the closed-loop system can be expressed as linear matrix inequality constraints. This brings the advantage that feasibility and optimal design parameters can be effectively computed while solving a linear optimisation problem. An advantage of the method is that it allows a systematic and quantitative evaluation of the interplay between the design parameters and their impact on the requirements. This produces an integrated linear/neuro-adaptive performance-oriented design methodology. A numerical example is used to illustrate the approach.     

Human Amnion-Derived Mesenchymal Stromal Cells: A New Potential Treatment for Carbapenem-Resistant Enterobacterales in Decompensated Cirrhosis

Background: Spontaneous bacterial peritonitis (SBP) is a severe and often fatal infection in patients with decompensated cirrhosis and ascites. The only cure for SBP is antibiotic therapy, but the emerging problem of bacterial resistance requires novel therapeutic strategies. Human amniotic mesenchymal stromal cells (hA-MSCs) possess immunomodulatory and anti-inflammatory properties that can be harnessed as a therapy in such a context. Methods: An in vitro applications of hA-MSCs in ascitic fluid (AF) of cirrhotic patients, subsequently infected with carbapenem-resistant Enterobacterales, was performed. We evaluated the effects of hA-MSCs on bacterial load, innate immunity factors, and macrophage phenotypic expression. Results: hA-MSCs added to AF significantly reduce the proliferation of both bacterial strains at 24 h and diversely affect M1 and M2 polarization, C3a complement protein, and ficolin 3 concentrations during the course of infection, in a bacterial strain-dependent fashion. Conclusion: This study shows the potential usefulness of hA-MSC in treating ascites infected with carbapenem-resistant bacteria and lays the foundation to further investigate antibacterial and anti-inflammatory roles of hA-MSC in in vivo models.     

红色物语——旧厂房成为新办公楼的改造方案

红色和黑色是具有历史意义的先锋颜色,在上个世纪它们代表着大胆不羁的意识形态和由革新方式表选的道德与文化信念所构成的艺术运动.这是那种能代表某种针对对象本质引发的潮流和张力的颜色,而白色代表用来罗列它们意义和内涵的虚无空间.