Human bladder cancer: evidence for a potential irritation-induced mechanism

Bladder cancer is one of the most common human cancers, constituting about 6% and 2% of all cancers among males and females, respectively. Over 90% of all bladder cancers are transitional cell carcinomas, with most of the remainder being squamous cell carcinomas. Smoking and occupational exposure to aromatic amines and other agents are most prominent among the risk factors identified. Inflammation of the bladder, largely by infection but also by stones or a combination of the two, may play some role in human bladder cancer development. The association between inflammation and cancer appears to be stronger for squamous cell than for transitional cell carcinoma. Stones and infection can be important factors in the development of bladder tumours in rodents, but the tumours are predominantly transitional cell rather than squamous cell carcinomas.     

Age, experience and the changing brain

In this review, various aspects of how environmental experience effects the structure of the cortex at different times in the age of the animal are summarized. The interactions of brain injury and sex on the age-dependent plastic changes in the cortex are also considered. Finally, we have attempted to reach some general conclusions that describe the effects of age, experience, sex, and injury on the cortex.     

3-4-Methylenedioxymethamphetamine-induced acute changes in dopamine transporter function

The activity of the moxidectin as an 1% w/v injectable solution on first instar Hypoderma spp. has been evaluated in sixteen naturally infested young cattle. The animals were selected on the basis of their serological status and allocated to two groups of eight animals. At the end of November, one group was treated with moxidectin at a dose rate of 0.2 mg/kg via the subcutaneous route and the non treated control calves injected with the vehicle. The serological status was assessed 1, 2, 4, 8 and 12 weeks post treatment and the presence of Hypoderma lumps determined every two weeks from February to June. A 100% efficacy of the injectable formulation was demonstrated. A progressive fall of the antibody levels was observed in the treated calves for one month following treatment, suggesting a progressive action of the test compound and a limited risk of hypersensitivity.     

Blockade of tachykinin NK1 receptors by CP-96345 enhances dopamine release and the striatal dopamine effects of methamphetamine in rats

The nonpeptide, tachykinin NK1 receptor antagonist, CP-96345, permits the study of the physiological role of extrapyramidal substance P systems. Using microdialysis, we observed that locally applied CP-96345 (200 nM) caused a significant increase in dopamine release in the striatum as well as substantially enhancing striatal dopamine release caused by a low dose of methamphetamine (0.5 mg/kg s.c.). In addition, multiple systemic administrations of CP-96345 almost doubled the dopamine-mediated responses of the striatal neurotensin and dynorphin systems to high doses of methamphetamine (10 mg/kg/dose s.c.). Our findings suggest that the physiological role of substance P released in the striatum is to decrease the activity of the nigrostriatal dopamine pathway.     

Selection of myocardial electrogram features for use by implantabledevices

Implantable devices that terminate ventricular tachycardia must be capable of correctly classifying heart rhythms to a high degree of reliability. The relative discriminating power of several myocardial electrogram features in six human subjects were evaluated by reducing the order of their corresponding feature spaces using three different optimization methods: minimizing univariate Bayes error rates (univariate parametric), maximizing the Kullback divergence (multivariate parametric), and pruning classification trees (nonparametric). It was found that although the composition of the optimal subspaces varied considerably from one subject to another, one frequency domain feature was common to most of the optimal subspaces     

Development of improved electrical-substitution radiometers at the National Research Council of Canada

We describe the development of a third generation of electrical-substitution radiometers (ESR's) at the National Research Council of Canada. The new ESR's follow the same general design as before, but incorporate improved thermopiles and electrical heating elements. The ESR's have a responsivity between 0.6 and 1.0 VW(-1), a time constant of approximately 2.0 s, a uniformity of 0.1% over a 6-mm-diameter region, and a noise level of approximately 6 nW. Performance characteristics of the new ESR's are discussed. It is shown that calibrations performed with these ESR's agree with those made with the previous generation of ESR's to better than 0.05%.     

Nondestructive evaluation sensor fusion with autonomous robotic system for civil infrastructure inspection

Civil infrastructure inspection is crucial to maintaining the quality of that infrastructure, which has a great impact on the economy. Performing this inspection is costly work that requires workers to be trained on how to use varying technologies, which can be error prone when performed manually and can result in damage to the infrastructure in some cases. For this reason, nondestructive evaluation (NDE) sensors are preferred for civil infrastructure inspection as they can perform the necessary inspection without damaging the infrastructure. In this paper, we develop a fully autonomous robotic system capable of real‐time data collection and quasi‐real‐time data processing. The robotic system is equipped with several NDE sensors that allow for a sensor fusion method to be developed that successfully minimizes inspection time while performing adequate inspection of areas that require more in‐depth data to be collected. A detailed discussion of the inspection framework developed for this robotic system, and the dual navigation modes for both indoor and outdoor autonomous navigation is presented. The developed robotic system is deployed to inspect several infrastructures (e.g., parking garages, bridges) at and near by the University of Nevada, Reno campus.     

The impact of fly ash resistivity and carbon content on electrostatic precipitator performance

Despite the wide use of electrostatic precipitators for particulate control in pulverised coal combustion, there are still some aspects surrounding the performance of these devices which are not fully understood, particularly with respect to high carbon ash. The introduction of low NO_x burners to meet more stringent emissions regulations has also resulted in an increase in the carbon present in fly ash. An investigation was carried to assess how the operating conditions of a pilot-scale single-stage electrostatic precipitator test facility (ESPTF) affected the collection efficiency of two high carbon fly ashes. Whilst our findings demonstrated the effectiveness of the ESPTF in collecting both fly ash and carbon particles, the performance of the high-resistivity fly ash was significantly better than expected, particularly at higher temperatures. It was concluded that ESP performance of any particular fly ash and the separation of the carbon fraction may not necessarily be predicted by its resistivity alone.     

Identification Of Sex Pheromone Components Of The Painted Apple Moth: A Tussock Moth With A Thermally Labile Pheromone Component

The sex pheromone of the painted apple moth, Teia anartoides (Lymantriidae) was investigated using GC-EAD and GC-MS analysis, derivatization, TLC analysis, and field cage and field trapping bioassays. The major sex pheromone components were identified as (6Z,9Z)-henicosa-6,9-dien-11-one and (6Z,9Z)-henicosa-6,9-diene. Other minor components of pheromone gland extracts included (6Z)-9R,10S-epoxyeicos-6-ene, (6Z)-9R,10S-epoxyhenicos-6-ene, (6Z,9Z)-henicosa-6,9-dien-11-ol, (6Z)-henicos-6-en-11-one, and (6Z, 8E)-henicosa-6,8-dien-11-one, but the roles of these minor components remain equivocal. In field cage and field experiments, a blend of all seven identified components [(6Z,9Z)-henicosa-6,9-dien-11-one (relative amount 100), (6Z,9Z)-henicosa-6,9-diene (100), (6Z)-9R,10S-epoxyeicos-6-ene (5), (6Z)-9R,10S-epoxyhenicos-6-ene (10), (6Z,9Z)-henicosa-6,9-dien-11-ol (5), (6Z)-henicos-6-en-11-one (1), and (6Z,8E)-henicosa-6,8-dien-11-one (25)] was as attractive to males as calling females, but tests with blends of the major component(s) with subsets of the minor components did not produce consistent results that unequivocally showed the various minor components to be critical components of the active blend. (6Z,9Z)-henicosa-6,9-dien-11-one is thermally labile and rearranges to (6Z,8E)-henicosa-6,8-dien-11-one and other products at ambient temperature, rendering the synthetic pheromone lure inactive after two days of field exposure.