Birefringent properties of diametrically loaded gradient-index lenses

Gradient-index (GRIN) lenses have been widely used as collimators in various fiber-optic sensors and as optical coupling devices in components designed for optical communication systems. However, relatively little attention has been paid to the birefringent properties of GRIN lenses and the potential for using them as photoelastic sensing elements in optical transducers. Analytical and experimental results are described that were obtained for the intensity distribution produced by studying a GRIN lens by using a polariscope. The residual birefringence inherent in an unloaded lens is initially studied. The lens is then assumed to be diametrically loaded and the superposition is studied by the method of ray tracing. When the results obtained from the simulation for a Selfoc, 0.25-pitch lens are compared with experimental data, an excellent agreement is obtained. Intensity increases monotonically with load, confirming that the lens would be a good choice for the sensing element of an optical transducer designed as part of a strain or acceleration measurement system. The numerical simulation is then used to study the influence of residual stress on sensitivity.     

Rambo: a robust, reconfigurable atomic memory service for dynamic networks

In this paper, we present Rambo, an algorithm for emulating a read/write distributed shared memory in a dynamic, rapidly changing environment. Rambo provides a highly reliable, highly available service, even as participants join, leave, and fail. In fact, the entire set of participants may change during an execution, as the initial devices depart and are replaced by a new set of devices. Even so, Rambo ensures that data stored in the distributed shared memory remains available and consistent. There are two basic techniques used by Rambo to tolerate dynamic changes. Over short intervals of time, replication suffices to provide fault-tolerance. While some devices may fail and leave, the data remains available at other replicas. Over longer intervals of time, Rambo copes with changing participants via reconfiguration, which incorporates newly joined devices while excluding devices that have departed or failed. The main novelty of Rambo lies in the combination of an efficient reconfiguration mechanism with a quorum-based replication strategy for read/write shared memory. The Rambo algorithm can tolerate a wide variety of aberrant behavior, including lost and delayed messages, participants with unsynchronized clocks, and, more generally, arbitrary asynchrony. Despite such behavior, Rambo guarantees that its data is stored consistency. We analyze the performance of Rambo during periods when the system is relatively well-behaved: messages are delivered in a timely fashion, reconfiguration is not too frequent, etc. We show that in these circumstances, read and write operations are efficient, completing in at most eight message delays.     

A branch-and-cut algorithm for the minimum labeling Hamiltonian cycle problem and two variants

This paper proposes a mathematical model, valid inequalities and polyhedral results for the minimum labeling Hamiltonian cycle problem. This problem is defined on an unweighted graph in which each edge has a label. The aim is to determine a Hamiltonian cycle with the least number of labels. We also define two variants of this problem by assigning weights to the edges and by considering the tour length either as an objective or as a constraint. A branch-and-cut algorithm for the three problems is developed, and computational results are reported on randomly generated instances and on modified instances from TSPLIB.     

Deriving industrial logistics hub reference models for manufacturing based economies

Global enterprises require extended logistics operations that integrate channel intermediaries into the network. The method for deriving integrated models for logistics hubs that improve the efficiency of manufacturers’ global operations is the focus of this paper. Under government sponsorship, six industrial logistics hubs were implemented by leading manufacturing sectors across Taiwan over a five year period from 2004 until 2008. Each industry sector had unique industry characteristics, business strategies, and logistics models. Therefore, this paper describes how generalized and quick to implement integrated logistics hubs are developed by studying the successful reference models and systems used by six independent industrial sectors. The research results provide a field tested method for deriving integrated logistics hub models in different manufacturing economies with notes that provide sufficient methodological detail for repeating the construction of logistics hubs in other manufacturing economies.     

Reconfigurable distributed storage for dynamic networks

This paper presents a new algorithm for implementing a reconfigurable distributed shared memory in an asynchronous dynamic network. The algorithm guarantees atomic consistency (linearizability) in all executions in the presence of arbitrary crash failures of the processing nodes, message delays, and message loss. The algorithm incorporates a classic quorum-based algorithm for read/write operations, and an optimized consensus protocol, based on Fast Paxos for reconfiguration, and achieves the design goals of: (i) allowing read and write operations to complete rapidly and (ii) providing long-term fault-tolerance through reconfiguration, a process that evolves the quorum configurations used by the read and write operations. The resulting algorithm tolerates dynamism. We formally prove our algorithm to be correct, we present its performance and compare it to existing reconfigurable memories, and we evaluate experimentally the cost of its reconfiguration mechanism.     

THE HUPO Human Plasma Proteome Project

The Human Proteomics Organization (HUPO) Human Plasma Proteome Project (PPP) is a prominent example of the inherently collaborative nature of the overall community effort to characterize the proteome of humans in health and disease. The PPP Pilot Phase, called "Exploring the Human Plasma Proteome", engaged 55 laboratories, four technical committees, and vendors and sponsors on an international scale. Among other outcomes, the PPP generated a Core Dataset of 3020 proteins identified with two or more peptides, fully accessible at EBI/PRIDE, ISB/PeptideAtlas, and University of Michigan websites, a rich resource for follow-on analyses. The PPP provided extensive annotation, correlation of number of peptides with protein concentrations measured by immunoassay, an algorithm for choice of a representative protein for multiple proteins matching a given peptide, and independent analyses from the raw spectra. The next phase of the PPP will emphasize standardized procedures for specimen handling, potent new technology platforms for discovery and for targeted proteomics, and robust informatics efforts, including comparative analyses of other biofluids.     

Prophylactic efficacy of tilmicosin for bovine respiratory tract disease

The prophylactic administration of injectable tilmicosin for pneumonia in weaned beef calves was investigated in 1,806 animals. Comparisons were made among calves receiving an "on-arrival" injection of tilmicosin, calves receiving a single injection of long-acting oxytetracycline, and calves receiving no prophylaxis. Morbidity and mortality attributable to pneumonia, morbidity and mortality attributable to all causes, and case fatality were significantly lower in the group of calves that received tilmicosin, compared with calves that received long-acting oxytetracycline and calves that received no prophylactic antibiotic. Mean time to initial pneumonia treatment was significantly extended in calves that received prophylaxis, compared with those that received no antibiotic on arrival at the feedlot. Calves that received tilmicosin gained significantly more weight than calves that received oxytetracycline. Calves that were not treated for pneumonia during the trial period gained significantly more weight than did those calves that were treated for pneumonia regardless of experimental group. The majority of mortalities were attributable to fibrinous pneumonia (31/34). Important bacterial isolates (Pasteurella spp, Haemophilus somnus, Actinomyces pyogenes) obtained at necropsy did not have resistance to tilmicosin in association with administration of tilmicosin as prophylaxis for pneumonia. However, bacterial resistance to trimethoprim/sulfonamide and to oxytetracycline were commonly found in these postmortem isolates.     

Comparison of technetium-99m-ECD to Xenon-133 SPECT in normal controls and in patients with mild to moderate regional cerebral blood flow abnormalities

Technetium-99m-1,1-ethyl cysteinate dimer (ECD) has been proposed as a "chemical microsphere" for SPECT measurement of regional cerebral blood flow (rCBF). However, its distribution has not yet been compared in humans to an established rCBF measure. Therefore, we compared the uptake and distribution of ECD with rCBF measured by 133Xe SPECT in subjects with mild to moderate flow abnormalities and in normal volunteers. Blood and urine chemistries and vital signs were unchanged from pre-ECD values up to seven days postinjection. Profile plots demonstrated pattern agreement between rCBF ratios (133Xe) and ECD count density ratios. A significant correlation of rCBF ratios to ECD count density ratios was observed (r = 0.77), with a slope of 0.64 and intercept of 0.36. To explore whether or not the relationship between rCBF and ECD was dependent on absolute flow, ECD region of interest data were expressed in units of ml/min/100 g by equating global CBF (133Xe) and ECD global count density. A closer correlation (r = 0.88) was found for these data than for the count ratio data. The slope was closer to one (m = 0.83) and the intercept was closer to zero (b = 8.2). Also, a significant correlation was observed between ECD-derived rCBF and 133Xe rCBF in the lesion area (r = 0.92) for patients with well-demarcated rCBF lesions. The slope (0.80) suggested a slight underestimation of lesion flow by ECD. Finally, ECD clearance from cortical gray matter ROIs derived from high-resolution scans from 1 to 4 hr postinjection was slow (2.4%/hr). In summary, ECD is a safe and effective marker of regional cerebral perfusion. The distribution of ECD is linearly related to rCBF measured by 133Xe SPECT, although our data suggest a mild underestimation of flow at the high end of the normal range.