A bio-inspired gelatin-based pH- and thermal-sensitive magnetic hydrogel for in vitro chemo/hyperthermia treatment of breast cancer cells

Gelatin (Gel)-based pH- and thermal-responsive magnetic hydrogels (MH-1 and MH-2) were designed and developed as novel drug delivery systems (DDSs) for cancer chemo/hyperthermia therapy. For this goal, Gel was functionalized with methacrylic anhydride (GelMA), and then copolymerized with (2-dimethylaminoethyl) methacrylate (DMAEMA) monomer in the presence of methacrylate-end capped magnetic nanoparticles (MNPs) as well as triethylene glycol dimethacrylate (TEGDMA; as crosslinker). Afterward, a thiol-end capped poly(N-isopropylacrylamide) (PNIPAAm-SH) was synthesized through an atom transfer radical polymerization technique, and then attached onto the hydrogel through “thiol-ene” click grafting. The preliminary performances of developed MHs for chemo/hyperthermia therapy of human breast cancer was investigated through the loading of doxorubicin hydrochloride (Dox) as an anticancer agent followed by cytotoxicity measurement of drug-loaded DDSs using MTT assay by both chemo- and chemo/hyperthermia-therapies. Owing to porous morphologies of the fabricated magnetic hydrogels according to scanning electron microscopy images and strong physicochemical interactions (e.g., hydrogen bonding) the drug loading capacities of the MH-1 and MH-2 were obtained as 72 ± 1.4 and 77 ± 1.8, respectively. The DDSs exhibited acceptable pH- and thermal-triggered drug release behaviors. The MTT assay results revealed that the combination of hyperthermia therapy and chemotherapy has synergic effect on the anticancer activities of the developed DDSs.     

Adaptive Network-Based Fuzzy Inference Systems Coupled with Genetic Algorithms for Predicting Soil Permeability Coefficient

This paper extends hybrid-type optimization models of genetic algorithm adaptive network-based fuzzy inference system (GA-ANFIS) for predicting the soil permeability coefficient (SPC) of different types of soil. In these models, GA optimizes parameters of a subtractive clustering technique that controls the structure of the ANFIS model’s fuzzy rule base. Simultaneously, a hybrid leaning algorithm is employed in the ANFIS, as a trained fuzzy inference system (FIS), which optimally determines the parameter sets of the examined FISs in ANFIS. Using an updated large database of SPCs consisting of 338 fine-grained, 178 mixed and 94 granular soil samples, GA-ANFIS framework constructs different models of predicting the permeability coefficient of respectively fine-grained, mixed and granular soils. A fuzzy C-mean technique has been used to cluster the entire data samples of each type of soil and divide them uniformly into training and testing data sets. Different prediction models of SPC have been trained and tested for each of the three soil types, and the appropriate models have been selected. The selected models have been compared with ANN and modified-by-GA empirical prediction models. Results show that the constructed GA-ANFIS models outperform the other models in terms of the prediction accuracy and the generalization capability.     

Textual image compression at low bit rates based on region-of-interest coding

In this paper, we deal with those applications of textual image compression where high compression ratio and maintaining or improving the visual quality and readability of the compressed images are of main concern. In textual images, most of the information exists in the edge regions; therefore, the compression problem can be studied in the framework of region-of-interest (ROI) coding. In this paper, the Set Partitioning in Hierarchical Trees (SPIHT) coder is used in the framework of ROI coding along with some image enhancement techniques in order to remove the leakage effect which occurs in the wavelet-based low-bit-rate compression. We evaluated the compression performance of the proposed method with respect to some qualitative and quantitative measures. The qualitative measures include the averaged mean opinion scores (MOS) curve along with demonstrating some outputs in different conditions. The quantitative measures include two proposed modified PSNR measures and the conventional one. Comparing the results of the proposed method with those of three conventional approaches, DjVu, JPEG2000, and SPIHT coding, showed that the proposed compression method considerably outperformed the others especially from the qualitative aspect. The proposed method improved the MOS by 20 and 30 %, in average, for high- and low-contrast textual images, respectively. In terms of the modified and conventional PSNR measures, the proposed method outperformed DjVu and JPEG2000 up to 0.4 dB for high-contrast textual images at low bit rates. In addition, compressing the high contrast images using the proposed ROI technique, compared to without using this technique, improved the average textual PSNR measure up to 0.5 dB, at low bit rates.     

Solving the Problem of Forbidden States in Discrete Event Systems: A Novel Systematic Method for Reducing the Number of Control Places

This paper deals with the problem of forbidden states in Discrete Event Systems modelled by non‐safe Petri Nets. To avoid these states, some Generalized Mutual Exclusion Constraints can be assigned to them. These constraints limit the weight sum of tokens in some places and can be enforced on the system using control places. When the number of these constraints is large, a large number of control places should be added to the system. In this paper, a method is presented to assign the small number of constraints to forbidden states using some states which cover the forbidden states. So, a small number of control places are added to the system leading to obtaining a maximally permissive controller.     

An automatic subdigraph renovation plan for failure recovery of composite semantic Web services

A Web service-based system never fulfills a user＇s goal unless a failure recovery approach exists. It is inevitable that several Web services may either perish or fail before or during transactions. The completion of a composite process relies on the smooth execution of all constituent Web services. A mediator acts as an intermediary between providers and consumers to monitor the execution of these services. If a service fails, the mediator has to recover the whole composite process or else jeopardize achieving the intended goals. The atomic replacement of a perished Web service usually does not apply because the process of locating a matched Web service is unreliable. Even the system cannot depend on the replacement of the dead service with a com- posite service. In this paper, we propose an automatic renova- tion plan for failure recovery of composite semantic services based on an approach of subdigraph replacement. A replacement subdigraph is posed in lieu of an original subdigraph, which includes the failed service. The replacement is done in two separate phases, ofltine and online, to make the recovery faster. The ofitine phase foresees all possible subdigraphs, pre-calculates them, and ranks several possible replacements. The online phase compensates the unwanted effects and executes the replacement subdigraph in lieu of the original subdigraph. We have evaluated our approach during an experiment and have found that we could recover more than half of the simulated failures. These achievements show a significant improvement compared to current approaches     

Spectral Measurement of the Film-Substrate Index Difference in Proton-Exchanged LiNbO(3) Waveguides

We report the spectral characterization of proton-exchanged lithium niobate (PE:LiNbO(3)) waveguides in terms of the variation of the refractive-index difference between the waveguiding layer and the substrate. The dispersion of the extraordinary refractive-index increase (deltan(e)) is measured from 405 to 1319 nm with several light sources. Two types of proton-exchanged waveguide, prepared under different conditions, are studied. These measurements should be of use in the optimization of PE:LiNbO(3) waveguides for nonlinear optical applications, particularly in second-harmonic generation in the blue-green wavelength region.     

Adaptive simulation of two dimensional hyperbolic problems by Collocated Discrete Least Squares Meshless method

An adaptive refinement technique is presented in this paper and used in conjunction with the Collocated Discrete Least Squares Meshless (CDLSM) method for the effective simulation of two-dimensional shocked hyperbolic problems. The CDLSM method is based on minimizing the least squares functional calculated at collocation points chosen on the problem domain and its boundaries. The functional is defined as the weighted sum of the squared residuals of the differential equation and its boundary conditions. A Moving Least Squares (MLS) method is used here to construct the meshless shape functions. An error estimator based on the value of functional at nodal points used to discretize the problem domain and its boundaries is developed and used to predict the areas of poor solutions. A node moving strategy is then used to refine the predicted zones of poor solutions before the problem is resolved on the refined distribution of nodes. The proposed methodology is applied to some two dimensional hyperbolic benchmark problems and the results are presented and compared to the exact solutions. The results clearly show the capabilities of the proposed method for the effective and efficient solution of hyperbolic problems of shocked and high gradient solutions.     

Unsupervised adaptive neural-fuzzy inference system for solving differential equations

There has been a growing interest in combining both neural network and fuzzy system, and as a result, neuro-fuzzy computing techniques have been evolved. ANFIS (adaptive network-based fuzzy inference system) model combined the neural network adaptive capabilities and the fuzzy logic qualitative approach. In this paper, a novel structure of unsupervised ANFIS is presented to solve differential equations. The presented solution of differential equation consists of two parts; the first part satisfies the initial/boundary condition and has no adjustable parameter whereas the second part is an ANFIS which has no effect on initial/boundary conditions and its adjustable parameters are the weights of ANFIS. The algorithm is applied to solve differential equations and the results demonstrate its accuracy and convince us to use ANFIS in solving various differential equations.