Particle Swarm Optimisation for Protein Motif Discovery

In this paper, a modified particle swarm optimisation algorithm is proposed for protein sequence motif discovery. Protein sequences are represented as a chain of symbols and a protein sequence motif is a short sequence that exists in most of the protein sequence families. Protein sequence symbols are converted into numbers using a one to one amino acid translation table. The simulation uses EGF protein and C2H2 Zinc Finger protein families obtained from the PROSITE database. Simulation results show that the modified particle swarm optimisation algorithm is effective in obtaining global optimum sequence patterns, achieving 96.9 and 99.5 classification accuracy respectively in EGF and C2H2 Zinc Finger protein families. A better true positive hit result is achieved when compared to the motifs published in PROSITE database.     

Computerized transcutaneous monitoring incorporating laser Doppler velocimetry

Measurements of transcutaneous oxygen tension, transcutaneous carbon dioxide tension, transcutaneous heater power, transcutaneous electrode temperature, and peripheral perfusion at the gas measurement site (assessed by laser Doppler velocimetry) are monitored by a microprocessor-based data acquisition system. Arterial blood pressure, central venous pressure, pulmonary artery pressure, respiration rate, and heart rate may be simultaneously captured with the system unattended for 12-hour intervals. This computerized monitoring system is mobile and easily applied by medical technologists to adult or neonatal intensive care patients. Simultaneous collection of the measurement data has facilitated research on the interrelationships of the measured parameters. It should be helpful in assessing optimal therapeutic interventions as well as the changing physiology of acutely ill patients.     

Variation in carotenoid–protein interaction in bird feathers produces novel plumage coloration

Light absorption by carotenoids is known to vary substantially with the shape or conformation of the pigment molecule induced by the molecular environment, but the role of interactions between carotenoid pigments and the proteins to which they are bound, and the resulting impact on organismal coloration, remain unclear. Here, we present a spectroscopic investigation of feathers from the brilliant red scarlet ibis (Eudocimus ruber, Threskiornithidae), the orange-red summer tanager (Piranga rubra, Cardinalidae) and the violet-purple feathers of the white-browed purpletuft (Iodopleura isabellae, Tityridae). Despite their striking differences in colour, all three of these feathers contain canthaxanthin (β,β-carotene-4,4′-dione) as their primary pigment. Reflectance and resonance Raman (rR) spectroscopy were used to investigate the induced molecular structural changes and carotenoid–protein interactions responsible for the different coloration in these plumage samples. The results demonstrate a significant variation between species in the peak frequency of the strong ethylenic vibration (ν₁) peak in the rR spectra, the most significant of which is found in I. isabellae feathers and is correlated with a red-shift in canthaxanthin absorption that results in violet reflectance. Neither polarizability of the protein environment nor planarization of the molecule upon binding can entirely account for the full extent of the colour shift. Therefore, we suggest that head-to-tail molecular alignment (i.e. J-aggregation) of the protein-bound carotenoid molecules is an additional factor.     

弃武从文的卡司克

<正>不必质疑卡司克的精密、耐用和可靠程度,因为孕育它的母体可是战争中那把直接致命的武器——左轮手枪。"我打赌你以前没有拿过枪。"面对着正在把玩.32口径左轮手枪的乔恩·索洛萨巴尔(Jon Solozabal),很难相信这句话竟是一位文具制造商的开场白。对乔恩和他的这座超过90岁的企业王国而言,手枪所代表的不仅是一段历史,更是一笔宝贵的遗产。     

Geometric Patterns,Light and Shade: Quantifying Aperture Ratio and Pattern Resolution in the Performance of Shading Screens

This research focuses on the application and performance assessment of geometric patterns as shading screens and shows how the geometric patterns can function as a design agency, an environmental control system, and a cultural element. We begin with a brief review of the underlying rules of creating two-dimensional geometric patterns, and then look at how these patterns evolve as three-dimensional shading screens in buildings. We next discuss a predictive model for translating complex patterns to simple patterns concerning their perforation ratio, granularity, and morphology. This is followed by an experimental and simulation study for measuring the daylighting performance of some simple shading screens. The result of this phase assesses the agreement among experimental and numerical studies. Finally, we evaluate the performance of a screen inspired by a Persian pattern.     

Predictive Thermal Inactivation Model for Effects and Interactions of Temperature, NaCl, Sodium Pyrophosphate, and Sodium Lactate on Listeria monocytogenes in Ground Beef

The effects and interactions of heating temperature (60 °C to 73.9 °C), salt (0.0 % to 4.5 %?w/v), sodium pyrophosphate (0.0 % to 0.5 %?w/v), and sodium lactate (0.0 % to 4.5 %?w/v) on the heat resistance of a five-strain mixture of Listeria monocytogenes in 75 % lean ground beef were examined. Meat samples in sterile filtered stomacher bags were heated in a temperature controlled waterbath to determine thermal death times. The recovery medium was tryptic soy agar supplemented with 0.6 % yeast extract and 1 % sodium pyruvate. Weibull survival functions were employed to model the primary survival curves. Then, survival curve-specific estimated parameter values obtained from the Weibull model were used for determining a secondary model. The results indicate that temperature and salt have a large impact on the inactivation kinetics of L. monocytogenes, while sodium lactate (NaL) has an impact in the presence of salt. The model presented in this paper for predicting inactivation of L. monocytogenes can be used as an aid in designing lethality treatments meant to control the presence of this pathogen in ready-to-eat products.     

Error detection for PHEV,BEV and stationary battery systems

Battery cells being electrically disconnected resulting from degradation, mechanical stress, or corrosion can lead to hazardous situations during operation of electric vehicles or storage systems in stationary applications. The mentioned errors can be acceptable in some cases when cells or cell strings are connected in parallel, but the failure is to be detected in order to guarantee the reliable and safe operation of the battery system. A method enabling the estimation whether individual battery cells are faulty (cell error or electrically disconnected) by evaluating the mean impedance and capacity information of cell groups is introduced and validated.