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91.
RA Newman JC Vidal LJ Viskatis J Johnson MA Etcheverry 《Canadian Metallurgical Quarterly》1993,11(2-3):151-159
Two purified animal venom toxins, crotoxin and cardiotoxin, have been combined to produce a unique natural product (VRCTC-310) currently under investigation as an antitumor agent by the National Cancer Institute. In vitro, it has demonstrated cytotoxic disease specificity and a unique mechanism of action when submitted to COMPARE analysis. In vivo, tolerance was developed to the neurotoxic properties of crotoxin which allowed comparison of several schedules of fixed and escalating daily i.m. doses to mice bearing s.c. Lewis Lung carcinoma. An 83% inhibition of tumor growth was achieved using an escalating dose schedule starting at 1.8 mg/kg and reaching 6.3 mg/kg/day on day 20. Although some irritation around the sites of i.m. injection was noted, animal weight loss was negligible and there were no other signs of adverse toxicity. This natural product represents a new, membrane interactive anticancer agent which produces a unique spectrum of cytotoxicity in vitro and which has demonstrated interesting in vivo antitumor efficacy. 相似文献
92.
MA Lindorfer CS Myung Y Savino H Yasuda R Khazan JC Garrison 《Canadian Metallurgical Quarterly》1998,273(51):34429-34436
The G protein beta5 subunit differs substantially in amino acid sequence from the other known beta subunits suggesting that beta gamma dimers containing this protein may play specialized roles in cell signaling. To examine the functional properties of the beta5 subunit, recombinant beta5 gamma2 dimers were purified from baculovirus-infected Sf9 insect cells using a strategy based on two affinity tags (hexahistidine and FLAG) engineered into the N terminus of the gamma2 subunit (gamma2HF). The function of the pure beta5 gamma2HF dimers was examined in three assays: activation of pure phospholipase C-beta in lipid vesicles; activation of recombinant, type II adenylyl cyclase expressed in Sf9 cell membranes; and coupling of alpha subunits to the endothelin B (ETB) and M1 muscarinic receptors. In each case, the efficacy of the beta5 gamma2HF dimer was compared with that of the beta1 gamma2HF dimer, which has demonstrated activity in these assays. The beta5 gamma2HF dimer activated phospholipase C-beta with a potency and efficacy similar to that of beta1 gamma2 or beta1 gamma2HF; however, it was markedly less effective than the beta1 gamma2HF or beta1 gamma2 dimer in its ability to activate type II adenylyl cyclase (EC50 of approximately 700 nM versus 25 nM). Both the beta5 gamma2HF and the beta1 gamma2HF dimers supported coupling of M1 muscarinic receptors to the Gq alpha subunit. The ETB receptor coupled effectively to both the Gi and Gq alpha subunits in the presence of the beta1 gamma2HF dimer. In contrast, the beta5 gamma2HF dimer only supported coupling of the Gq alpha subunits to the ETB receptor and did not support coupling of the Gi alpha subunit. These results suggest that the beta5 gamma2HF dimer binds selectively to Gq alpha subunits and does not activate the same set of effectors as dimers containing the beta1 subunit. Overall, the data support a specialized role for the beta5 subunit in cell signaling. 相似文献
93.
钢管内径光电检测装置 总被引:3,自引:0,他引:3
介绍了一种检测细长钢管内径的光电检测装置。该装置利用线阵CCD作传感器,采用8031单片机作为主控制。 相似文献
94.
本文研究在13SiMnNiCrMoV 结构钢中用尖裂纹的应力强度因子来反映三点弯曲缺口试样的疲劳裂纹萌生规律。当 R=0.1,f=100Hz,试样尺寸 B×W×L=12.5×25×117mm 时,缺口名义应力幅的门槛值为Δσ_(th)=3315ρ~(0.352) MPa,0.5mm≤ρ≤5mmΔK_(th)=250ρ~(0.352) MPam~(1/2)门槛值与ρ有关。同时得到缺口裂纹萌生的循环次数 N_i 与名义应力幅Δσ、缺口曲率半径ρ的定量关系是N_i=3.98×10~(22)ρ~(1.62)/Δσ~(4.85),N_i≤10~(5.5)并讨论了(ΔK_1/ρ~(1/2))_(th)与ρ无关的结论。 相似文献
95.
96.
RM Martín‐Aranda E Ortega‐Cantero ML Rojas‐Cervantes MA Vicente‐Rodríguez MA Baares‐Muoz 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2005,80(2):234-238
α,β‐Unsaturated nitriles have been synthesized by Knoevenagel condensation of a carbonylic compound with malononitrile, assisted by sonochemical irradiation. Two alkaline‐promoted clays (Li+‐ and Cs+‐exchanged saponites) have been employed as catalysts. The influence of the carbonylic compound (benzaldehyde or cyclohexanone) and the use of a solvent on the catalytic activity have been studied. Remarkable increase in the conversion values has been found when the reaction is activated by ultrasound, as compared with the thermal activation. In this green, solvent‐free procedure, α,β‐unsaturated nitriles have been produced in very high yields (97%) when the Cs+‐saponite is used as catalyst. Copyright © 2004 Society of Chemical Industry 相似文献
97.
98.
山东改造工程旧房质量检测 总被引:5,自引:4,他引:1
结合某成品仓库改作商业用房的工程实例,对该建筑进行了详细的检测与分析,并根据结果提出了针对性的加固方案,并对加固效果进行了探讨,为工程改造提供了依据,可供类似工程借鉴。 相似文献
99.
Wenhui MA Gang XIE Hua WANGFaculty of Materials Metallurgical Engineering Kunming University of Science Technology Kunming China Manuscript received January in revised form May 《材料科学技术学报》2002,18(3):286-287
The thermal expansion behavior of La1-xSrxMn1-yCoyO3-δ (x=0.2-0.4, y=0.1-0.3) perovskites in air has been investigated. The average linear thermal expansion coefficients increased with increasing Sr content up to 40 mole fraction or Co content up to 30 mole fraction. The expansion is generally attributed to an increase in the average cation radius as some of the cations in the perovskite are reduced in valence when oxygen ions are removed from the structure. 相似文献
100.