Organic Nanoprobe Cocktails for Multilocal and Multicolor Fluorescence Imaging of Reactive Oxygen Species

Hypochlorite (ClO^?) as a highly reactive oxygen species not only acts as a powerful “guarder” in innate host defense but also regulates inflammation‐related pathological conditions. Despite the availability of fluorescence probes for detection of ClO^? in cells, most of them can only detect ClO^? in single cellular organelle, limiting the capability to fully elucidate the synergistic effect of different organelles on the generation of ClO^?. This study proposes a nanoprobe cocktail approach for multicolor and multiorganelle imaging of ClO^? in cells. Two semiconducting oligomers with different π‐conjugation length are synthesized, both of which contain phenothiazine to specifically react with ClO^? but show different fluorescent color responses. These sensing components are self‐assembled into the nanoprobes with the ability to target cellular lysosome and mitochondria, respectively. The mixture of these nanoprobes forms a nano‐cocktail that allows for simultaneous imaging of elevated level of ClO^? in lysosome and mitochondria according to fluorescence color variations under selective excitation of each nanoprobe. Thus, this study provides a general concept to design probe cocktails for multilocal and multicolor imaging.     

面向Web领域的构件库系统的设计与实现

软件复用技术被认为是解决软件危机的有效方法,可以大幅度提高软件开发效率和质量,其核心是建立可复用构件库系统.构件库系统最主要的问题是如何对构件进行准确描述和分类,以便更快、更准地查找到用户需要的构件.在此采用刻面分类方法在Web应用开发领域中建立软件构件库,完成了构件的定义和准确描述及分类.确定了构件的存储模型,采用关键字检索和刻面分类检索两种检索方式,有效提高了检索效率和准确性,实现了在Web应用开发中对软件复用的支持.     

AlGaN/GaN HEMT 小信号模型提取方法的改进

The accurate extraction of AlGaN/GaN HEMT small-signal models, which is an important step in largesignal modeling, can exactly reflect the microwave performance of the physical structure of the device. A new method of extracting the parasitic elements is presented, and an open dummy structure is introduced to obtain the parasitic capacitances. With a Schottky resistor in the gate, a new method is developed to extract Rg. In order to characterize the changes of the depletion region under various drain voltages, the drain delay factor is involved in the output conductance of the device. Compared to the traditional method, the fitting of S 11 and S 22 is improved, and fT and fmax can be better predicted. The validity of the proposed method is verified with excellent correlation between the measured and simulated S-parameters in the range of 0.1 to 26.1 GHz.     

高速移动环境下TD-SCDMA系统组网方案研究

本文针对TD-SCDMA网络高速移动环境下的组网问题,分析了高速移动对系统性能可能产生的各类影响,包括多普勒频移对解调性能影响、智能天线赋形、功率控制和同步、网络切换、重选及车体穿透损耗的影响;结合频偏校正算法,给出了满足覆盖质量和切换要求的基站布局原则,并对专网和大网两种组网方式进行了分析比较。     

基于锗硅异质纳米晶的非易失浮栅存储器的存储特性

利用自组织生长和选择化学刻蚀方法在超薄SiO2隧穿氧化层上制备了渐变锗硅异质纳米晶,并通过电容.电压特性和电容-时间特性研究了该纳米结构浮栅存储器的存储特性.测试结果表明,该异质纳米晶非易失浮栅存储器具有良好的空穴存储特性,这是由于渐变锗硅异质纳米晶中Ge的价带高于Si的价带形成了复合势垒,空穴有效地存储在复合势垒的Ge的一侧.     

校园CPU卡密钥管理系统的设计与实现

文章研究了密钥管理系统在校园一卡通系统中的应用模式。首先以CPU卡技术和密码算法技术为基础,提出了一卡通系统的密钥管理系统的解决方案;然后针对系统的实现,描述了密钥分散的设计和实现过程;最后对系统中使用的算法进行了描述。密钥管理系统保证了高强度的校园一卡通系统的安全性。     

环形孔径对部分相干光光谱的影响

本文推导了部分相干光在经过环形孔径之后,远场轴上点的光谱S(ω)与环形孔径处光的光谱S~(0)(ω)之间的关系。数值计算结果表明,S(ω)不仅依赖于S~(0)(ω),而且还与环形孔径处光的相干性以及环形孔径的参数有关。     

双色红外系统的参数优化设计及作用距离的计算与分析

对采用玫瑰线图形扫描的红外搜索与跟踪系统的技术参数选取以及作用距离计算等问题，进行了系统的研究。提出了有效的计算方法和专用程序，并作了必要的评述与分析，全文以一具体的实验系统，对方法和过程作进一步的论述。     

输油管道油流带电的计算模型

给出了层流和紊流条件下新的管道油流带电计算模型。基于Gavis J的放电机理,对管壁-油界面处的边界条件提出了一种新的确定方法。分别推导出了两种流态下简单管道内电荷输运方程的表达式,并对方程的边界条件处理进行了研究。计算模型中考虑了油流速度、油的电导率和油温等因素对油流带电的影响,克服了以往模型中存在着难以确定的变量的缺点。利用计算模型对两条实验油道的油流带电量进行了计算,计算值和实验值的对比结果表明,计算值和实验值比较吻合。     

听觉距离的声学因素

讨论听觉距离定位的研究情况,总结了包括声源的声压级和频谱、听音环境引起的反射声以及人头和耳壳引起的散射作用等声学因素。