The granulomatous response in murine Schistosomiasis mansoni does not switch to Th1 in IL-4-deficient C57BL/6 mice

IL-4 plays an important role in polarizing inflammation toward a Th2 response. It remains uncertain, however, whether IL-4 also serves to prevent expression of Th1 inflammation. Therefore, using a genetically pure C57BL/6 IL-4-deficient mouse, we studied the role of IL-4 in regulating the production of IFN-gamma and Th1 inflammation in the granulomas of mice infected with Schistosoma mansoni. In contrast to normal animals, IL-4 mutant mice generated smaller liver granulomas that contained fewer eosinophils and no mast cells. Collagenase-dispersed granuloma cells were analyzed by flow cytometry and cultured in vitro to measure cytokine and Ig production. Compared with control granuloma cells, IL-4-/- cells secreted only small quantities of IL-5 and IL-10. Also, there was impaired expression of the IL-4-dependent molecules IgE and IgG1 as well as B cell surface class II and CD23. Yet the granulomas of IL-4 -/- animals produced little IFN-gamma, IgG2a, or other molecules associated with Th1 inflammation even after Ag or anti-CD3 stimulation. Splenocytes from IL-4 -/- animals stimulated with schistosome Ag also failed to produce a Th1 response. Our data show that most aspects of the Th2 response in murine schistosomiasis are highly dependent on IL-4 production. But in the absence of IL-4, neither the natural local granulomatous response to schistosome ova nor the systemic response to soluble egg Ag switches to the type 1 phenotype. Thus the production of IL-4 early in the inflammatory response is not the only factor preventing Th1 expression in inflammation.     

溶胶-凝胶法制备(Sr,Pb)TiO3纳米晶粉及表征

采用溶胶－凝胶法成功地合成了（Sr,Pb)TiO3纳米晶粉，并利用FTIR技术对凝胶的形成过程及350℃，1．5h煅烧获得的粉体材料进行了表征。实验以TG－DSC分析作为拟定煅烧温度的依据，以XRD作为煅烧产物的分析手段，最佳煅烧温度为600℃，所合成的（Sr,Pb)TiO3纳米晶粉的平均晶粒尺寸约为21nm，属钙钛矿型立方顺电相结构。     

EWSD中的ADSL.lite和xDSL

在简单介绍了ADSL技术的基础上,具体介绍了如何在EWSDU交换机中创速和设置ADSL用户功能和xDSL功能.     

某尾矿库周围环境中污染物生态转移研究

对我国某尾矿库周围环境中放射性核素U、^226Ra、Th及非放污染物Mn^2 、Cd、Cr、Pb在农作物和水生生物等介质中的浓集情况进行了现场研究，给出了相应的污染物生态学转移系数Bv和Bp值。     

Diagnostic Data Compression Techniques for Embedded Memories with Built-In Self-Test

A system-on-chip (SOC) usually consists of many memory cores with different sizes and functionality, and they typically represent a significant portion of the SOC and therefore dominate its yield. Diagnostics for yield enhancement of the memory cores thus is a very important issue. In this paper we present two data compression techniques that can be used to speed up the transmission of diagnostic data from the embedded RAM built-in self-test (BIST) circuit that has diagnostic support to the external tester. The proposed syndrome-accumulation approach compresses the faulty-cell address and March syndrome to about 28% of the original size on average under the March-17N diagnostic test algorithm. The key component of the compressor is a novel syndrome-accumulation circuit, which can be realized by a content-addressable memory. Experimental results show that the area overhead is about 0.9% for a 1Mb SRAM with 164 faults. A tree-based compression technique for word-oriented memories is also presented. By using a simplified Huffman coding scheme and partitioning each 256-bit Hamming syndrome into fixed-size symbols, the average compression ratio (size of original data to that of compressed data) is about 10, assuming 16-bit symbols. Also, the additional hardware to implement the tree-based compressor is very small. The proposed compression techniques effectively reduce the memory diagnosis time as well as the tester storage requirement.     

Excavation of Inlet Tunnels at Geheyan Power Station

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浅谈国企改革中的内部财务集中控制问题

一个完善的公司治理结构 ,应该是在明晰产权的基础上的三权 (决策权、监督权、经营权 )分立 ,各司其职 ,相互制衡的运行机制。财务总监委派制是近年来大型集团公司所实行的一种较有效的管理方式 ,是在企业财产所有权与经营权相分离情况下 ,集团公司通过委派财务总监参与企业重大经营决策 ,组织和监控企业日常财务活动 ,实现企业内部财务集中控制。使所有者及时获悉企业经营情况 ,确保了会计资料的真实性 ,提高了企业的竞争力