Effects of Cancer Presence and Therapy on the Platelet Proteome

Platelets are involved in tumor angiogenesis and cancer progression. Previous studies indicated that cancer could affect platelet content. In the current study, we investigated whether cancer-associated proteins can be discerned in the platelets of cancer patients, and whether antitumor treatment may affect the platelet proteome. Platelets were isolated from nine patients with different cancer types and ten healthy volunteers. From three patients, platelets were isolated before and after the start of antitumor treatment. Mass spectrometry-based proteomics of gel-fractionated platelet proteins were used to compare patients versus controls and before and after treatment initiation. A total of 4059 proteins were detected, of which 50 were significantly more abundant in patients, and 36 more in healthy volunteers. Eight of these proteins overlapped with our previous cancer platelet proteomics study. From these data, we selected potential biomarkers of cancer including six upregulated proteins (RNF213, CTSG, PGLYRP1, RPL8, S100A8, S100A9) and two downregulated proteins (GPX1, TNS1). Antitumor treatment resulted in increased levels of 432 proteins and decreased levels of 189 proteins. In conclusion, the platelet proteome may be affected in cancer patients and platelets are a potential source of cancer biomarkers. In addition, we found in a small group of patients that anticancer treatment significantly changes the platelet proteome.     

Towards impedance-based temperature estimation for Li-ion battery packs

In order to meet the required power and energy demand of battery-powered applications, battery packs are constructed from a multitude of battery cells. For safety and control purposes, an accurate estimate of the temperature of each battery cell is of vital importance. Using electrochemical impedance spectroscopy (EIS), the battery temperature can be inferred from the impedance. However, performing EIS measurements simultaneously at the same frequency on each cell in a battery pack introduces crosstalk interference in surrounding cells, which may cause EIS measurements in battery packs to be inaccurate. Also, currents flowing through the pack interfere with impedance measurements on the cell level. In this paper, we propose, analyse, and validate a method for estimating the battery temperature in a battery pack in the presence of these disturbances. First, we extend an existing and effective estimation framework for impedance-based temperature estimation towards estimating the temperature of each cell in a pack in the presence of crosstalk and (dis)charge currents. Second, the proposed method is analysed and validated on a two-cell battery pack, which is the first step towards development of this method for a full-size battery pack. Monte Carlo simulations are used to find suitable measurement settings that yield small estimation errors and it is demonstrated experimentally that, over a range of temperatures, the method yields an accuracy of ±1°C in terms of bias, in the presence of both disturbances.     

Stable Light-Emitting Electrochemical Cells Using Hyperbranched Polymer Electrolyte

The choice of an adequate electrolyte is a fundamental aspect in polymer light-emitting electrochemical cells (PLECs) as it provides the in situ electrochemical doping and influences the performance of these devices. In this study, a hyperbranched polymer (Hybrane DEO750 8500) blended with a Li salt is used as a novel electrolyte in state-of-the-art Super Yellow (a polyphenylenevinylene) based LECs. Due to the desirable properties of the hyperbranched polymer and the homogeneous and smooth films that it forms with the emitting polymer, PLEC with excellent electroluminescent properties are obtained using a pulsed current bias scheme. The devices are very stable, with lifetimes in excess of 2000 h with initial luminance values above 450 cd m⁻², a peak efficiency of 12.6 lm W⁻¹, and sub-minute turn-on times. The stability of the devices is also studied by measuring the photoluminescence (PL) of the semiconductor during electroluminescent operation. The findings suggest that it is possible to observe the quenching of the PL in vertically stacked devices due to the advancement of the doped fronts in the film and an immediate PL recovery when the bias is removed.     

Supramolecular Antifouling Additives for Robust and Efficient Functionalization of Elastomeric Materials: Molecular Design Matters

The ultimate functionality of elastomeric materials can be largely influenced by the molecular design of antifouling additives that interact through directed hydrogen bonding bisurea motifs. Herein, three additives, composed of matching bisurea groups and antifouling oligo(ethylene glycol) (OEG) functionalities, are judiciously designed. The first additive is composed of one bisurea and one OEG, the second additive of one bisurea and two OEGs, and the third additive of two bisurea and one OEG. On solution‐cast films, non‐cell adhesive properties are dependent on the amount of incorporated OEG irrespective of the bisurea design; however, on 3D electrospun scaffolds only the additive that consists of two bisurea moieties connected via an OEG functionality ensures proper non‐cell adhesive properties. Interestingly, robust non‐cell adhesive properties are maintained, both with repeated cell seeding and after partial enzymatic degradation of the scaffold. These results highlight the importance of additive design in supramolecular functionalization and show that translation from simple 2D solution‐cast films to 3D electrospun scaffolds is not trivial with respect to additive presentation and functionality.     

Artificial Channels in an Infectious Biofilm Created by Magnetic Nanoparticles Enhanced Bacterial Killing by Antibiotics

The poor penetrability of many biofilms contributes to the recalcitrance of infectious biofilms to antimicrobial treatment. Here, a new application for the use of magnetic nanoparticles in nanomedicine to create artificial channels in infectious biofilms to enhance antimicrobial penetration and bacterial killing is proposed. Staphylococcus aureus biofilms are exposed to magnetic‐iron‐oxide nanoparticles (MIONPs), while magnetically forcing MIONP movement through the biofilm. Confocal laser scanning microscopy demonstrates artificial channel digging perpendicular to the substratum surface. Artificial channel digging significantly (4–6‐fold) enhances biofilm penetration and bacterial killing efficacy by gentamicin in two S. aureus strains with and without the ability to produce extracellular polymeric substances. Herewith, this work provides a simple, new, and easy way to enhance the eradication of infectious biofilms using MIONPs combined with clinically applied antibiotic therapies.     

A critical comparative analysis of five world university rankings

Scientometrics - To provide users insight into the value and limits of world university rankings, a comparative analysis is conducted of five ranking systems: ARWU, Leiden, THE, QS and U-Multirank....     

Do journals flipping to gold open access show an OA citation or publication advantage?

The effects of Open Access (OA) upon journal performance are investigated. The key research question holds: How does the citation impact and publication output of journals switching (“flipping”) from non-OA to Gold-OA develop after their switch to Gold-OA? A review is given of the literature, with an emphasis on studies dealing with flipping journals. Two study sets with 119 and 100 flipping journals, derived from two different OA data sources (DOAJ and OAD), are compared with two control groups, one based on a standard bibliometric criterion, and a second controlling for a journal’s national orientation. Comparing post-switch indicators with pre-switch ones in paired T-tests, evidence was obtained of an OA Citation advantage but not of an OA Publication Advantage. Shifts in the affiliation countries of publishing and citing authors are characterized in terms of countries’ income class and geographical world region. Suggestions are made for qualitative follow-up studies to obtain more insight into OA flipping or reverse-flipping.

     

The citation impact of social sciences and humanities upon patentable technology

This paper examines the citation impact of papers published in scientific-scholarly journals upon patentable technology, as reflected in examiner- or inventor-given references in granted patents. It analyses data created by SCImago Research Group, linking PATSTAT’s scientific non-patent references (SNPRs) to source documents indexed in Scopus. The frequency of patent citations to journal papers is calculated per discipline, year, institutional sector, journal subject category, and for “top” journals. PATSTAT/Scopus-based statistics are compared to those derived from Web of Science/USPTO linkage. A detailed assessment is presented of the technological impact of research publications in social sciences and humanities (SSH). Several subject fields perform well in terms of the number of citations from patents, especially Library and Information Science, Language and Linguistics, Education, and Law, but many of the most cited journals find themselves in the interface between SSH and biomedical or natural sciences. Analyses of the titles of citing patents and cited papers are presented that shed light upon the cognitive content of patent citations. It is proposed to develop more advanced indicators of citation impact of papers upon patents, and ways to combine citation counts with citation content and context analysis.