Sub-5 keV electron-beam lithography in hydrogen silsesquioxane resist

We fabricated 9-30 nm half-pitch nested Ls and 13-15 nm half-pitch dot arrays, using 2 keV electron-beam lithography with hydrogen silsesquioxane (HSQ) as the resist. All structures with 15 nm half-pitch and above were fully resolved. We observed that the 9 and 10-nm half-pitch nested Ls and the 13-nm-half-pitch dot array contained some resist residues. We obtained good agreement between experimental and Monte-Carlo-simulated point-spread functions at energies of 1.5, 2, and 3 keV. The long-range proximity effect was minimal, as indicated by simulated and patterned 30 nm holes in negative-tone resist.     

Lightwave primer

This paper presents an introduction to the principles of lightwave system engineering. The treatment is historical rather than categorical-lightwave systems are described in terms of their evolution through four generations of technology, from a first generation operating at 0.85 μm wavelength over multimode fiber to a fourth generation employing coherent techniques at 1.55 μm. Basic engineering considerations such as fiber dispersion and receiver sensitivity are introduced early, then refined as the discussion progresses toward higher-performance, more sophisticated systems. The fundamental mechanisms that limit the performance of a given technology are quantified, and a figure of merit, the product of bit rate times maximum repeater spacing, is estimated. Values of this product range from about 2 Gbits/s . km for first-generation technology to roughly 900 Gbits/s . km for coherent systems.     

Locking range and stability of injection locked 1.54 µm InGaAsp semiconductor lasers

Measurements of the intensity of an injection locked 1.54 μm InGaAsP laser are reported. The change in intensity of the locked laser across the locking range is quite asymmetric, with a shape that agrees well with the theory of Lang. A linewidth parameter ofalpha = 6 pm 1was determined from the magnitude of the locking range. The injection locked laser was found to be unstable on the high frequency end of the locking range. The physical origin of this instability is explained in terms of a laser intensity change altering the phase of the laser field relative to that of the injected field.     

Theory of spontaneous emission noise in open resonators and its application to lasers and optical amplifiers

A theory of spontaneous emission noise is presented based on classical electromagnetic theory. Unlike conventional theories of laser noise, this presentation is valid for open resonators. A local Langevin force is added to the wave equation to account for spontaneous emission. A general expression is found relating the diffusion coefficient of this force to the imaginary part of the dielectric function. The fields of lasers and amplifiers are found by solving the wave equation by the Green's function method. The lasing mode is a resonant state associated with a pole in Green's function. In this way, noise in lasers and amplifiers is treated by a unified approach that is valid for either gain guiding or index guiding. The Langevin rate equations for the laser are derived. The theory is illustrated with applications to traveling wave and Fabry-Perot amplifiers and Fabry-Perot lasers. Several new results are found: optical amplifier noise increases inversely with quantum efficiency; spontaneous emission into the lasing mode is enhanced in lasers with low facet reflectivities; and the linewidth of a Fabry-Perot laser with a passive section decreases as the square of the fraction of the cavity optical length that is active.     

Autoxidation of methyl linolenate and methyl linoleate: The effect of α-tocopherol

α-Tocopherol substantially affects the distribution of peroxidic compounds formed during the autoxidation of methyl linolenate and methyl linoleate. In the autoxidation of both these unsaturated fatty acid esters the proportion of monohydroperoxides with conjugated double bonds in the trans, trans configuration is reduced until at high concentrations of α-tocopherol (5%) only cis, trans isomers are formed. In the autoxidation of methyl linolenate the proportion of hydroperoxy-epidioxides is reduced and only monohydroperoxides are formed when 5% α-tocopherol is present. The results are discussed in terms of recent findings concerning the mechanism of the autoxidation of unsaturated lipids.     

Apparent chemical composition of nine commercial or semi-commercial whey protein concentrates, isolates and fractions

Summary Analytical results are given for whey powders prepared on a commercial or semi-commercial scale by three companies. Altogether, five preparations enriched in β-lactoglobulin, four whey protein isolates and a fraction enriched in α-lactalbumin were analyzed for protein composition, including %β-lactoglobulin, α-lactalbumin, bovine serum albumin, casein (glyco) macropeptide and the main triglycerides. Protein composition was determined by high pressure gel permeation and reversed phase liquid chromatography and by capillary zone electrophoresis. The extent of modification of the native β-lactoglobulin structure was also measured through the degree of lactosylation and the fraction of accessible free sulphydryl groups. One significant finding was that the calculated recovery of protein following quantitation of the chromatogram or electropherogram was seldom above 90% and occasionally below 60% of that loaded onto the column or capillary, raising doubts as to the reliability of the analytical results. Extrapolation by linear regression to 100% recovery allowed estimates to be made of the true β-lactoglobulin composition of the samples. The nine samples could be placed into three distinct groups with estimated true β-lactoglobulin weight % of 70.9 ± 1.1, 62.0 ± 3.4 and 39.5 ± 4.9. Physico-chemical properties of the group of samples are reported elsewhere (Holt et al ., 1999).     

MULTIPLE FORMS OF α-AMYLASE IN MALTING BARLEY VAR. EMMA.

Multiple forms of α-amylase arise from translation of separate messages and post-translational proteolytic modification during malting. α-amylase activity is tolerant of proteolysis. The enzyme appears to have two domains one of which is associated with starch cleavage. The second site which binds cyclodextrin is destroyed by proteolysis. Cleavage yields a low molecular weight form which retains α-amylase activity.     

Roles of anoxia and noise-induced hearing loss in the postictal refractory period for audiogenic seizures in mice.

Three experiments with 188 Ss demonstrated a postictal refractory period for audiogenic seizures in DBA/2J mice, which was not related to hearing loss but apparently was related to anoxia. Exp I controlled for the effects of noise exposure upon hearing sensitivity and demonstrated reduced susceptibility to subsequent audiogenic seizures for at least 1 hr after initial clonic-tonic convulsions. The postictal refractory period resulted from the occurrence of seizures per se, not from noise exposure alone. Exp II demonstrated deficiencies of sensorimotor functions that accompanied reduced postictal seizure susceptibility. The 2 phenomena had similar time courses of recovery, which suggested a common mechanism, probably anoxia, associated with the initial convulsions. In support of this view, Exp III shows that recovery from both phenomena was expedited by allowing Ss to breathe increased O-sub-2. The role of anoxia in fatal convulsions is suggested by the finding that Ss experiencing clonic-tonic convulsions in a high-O-sub-2 environment survived without exception. In contrast, seizures of air-breathing controls were almost always fatal. The data indicate that the postictal reduced susceptibility to audiogenic seizures was closely related to metabolic depletion (in particular, anoxia). The pattern of recovery of susceptibility further suggests that the effects of anoxia impair the spread of seizure activity through the CNS, although the initiation of seizures is also affected for a short time. (44 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)