Capsosomes with Multilayered Subcompartments: Assembly and Loading with Hydrophobic Cargo

Therapeutic artificial cells or organelles are nanoengineered vehicles that are expected to substitute for missing or lost cellular function. The creation of capsosomes, polymer carrier capsules containing liposomal subcompartments, is a promising approach towards constructing such therapeutic devices using the layer‐by‐layer assembly method. Herein, the assembly of intact, nonaggregated capsosomes containing multiple liposome layers is reported. It is also further demonstrated that thiocoraline, a hydrophobic model peptide with antitumor activity, can be efficiently loaded into the membrane of the liposomal subcompartments of the capsosomes. Cell viability assays verify the activity of the trapped antitumor cargo. It is also shown that pristine capsosomes do not display inherent cytotoxic effects. The ability to tune the number of liposome layers and hence the drug loading in capsosomes as well as their noncytotoxicity provide new opportunities for the creation of therapeutic artificial cells and organelles.     

A multi-objective control strategy for grid connection of DG (distributed generation) resources

This paper presents a flexible control technique for connection of DG (distributed generation) resources to distribution networks, especially during ride-through on faulty grid. This strategy is derived from the abc/αβ and αβ/dq transformations of the ac system variables. The active and reactive currents injected by the DG source are controlled in the synchronously rotating orthogonal dq reference frame. The transformed variables are used to control the VSI (voltage source inverter) which connects the DG to the distribution network. Using a P.L.L. (phase locked loop) in circuit of proposed control technique, the angle of positive sequence has been detected, in order to synchronize the currents to the distribution network. The proposed control technique has the capability of providing active and reactive powers and harmonic currents to nonlinear loads with a fast dynamic response. Simulation results and mathematical analysis have been completed in order to achieve a reduced THD (total harmonic distortion), increased power factor and compensated load’s active and reactive powers. The analyses show the high performance of this control strategy in DG applications in comparison with other existing strategies.     

Comparison of color gamuts among several types of paper with the same printing technology

In this work, we have studied the relationship among the colorimetric properties of different types of paper, having different finishing and grammage. Their color reproduction capability has also been analyzed by using the same printing technology (inkjet printing). On the one hand, we have plotted CIELAB data under the illuminant D50 into constant lightness and hue‐angle planes to be compared with MacAdam limits and with Pointer's real‐world surface color. On the other hand, we have calculated the volume gamut of the color solid associated to each color paper gamut. Analyzing the results, we have checked that there is not any clear relationship among the colorimetric properties of paper (for instance, CIE whiteness index, etc.) and the color gamut volume associated. However, the colorimetric parameters associated to the printed sample showed a quite good linear correlation between the minimum lightness (or the maximum blackness value) of the printed color chart and the color gamut volume. In particular, the greatest color gamut volume corresponds to the glossy papers taking into account this correlation for inkjet printing. © 2009 Wiley Periodicals, Inc. Col Res Appl, 34, 330–336, 2009     

Effects of peer support and therapist contact on long-term weight loss.

This study evaluated the effectiveness of two posttreatment programs designed to enhance the maintenance of weight loss. Eighty-five obese clients were randomly assigned to either (a) behavior therapy plus a peer-support maintenance program, (b) behavior therapy plus a therapist-contact maintenance program, or (c) behavior therapy only. At a 7-month follow-up session, the therapist-contact program resulted in significantly greater maintenance of weight loss compared with the peer support and behavior therapy only conditions. However, by the time of an 18-month follow-up assessment, overall relapse rates were equivalent across conditions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Synthesis and characterization of core–shell SiO2@(Er3+,Yb3+):Lu2O3

We synthesized crystalline Erbium Er³⁺ and Ytterbium Yb³⁺ codoped -Lu₂O₃ nanolayers on SiO₂ microspheres using the modified Pechini method. Two different kinds of precursors, nitrates and chlorides, have been used leading to a layer-to-layer morphology and necklaces structures, respectively. In both cases, the size of nanocrystallites constituting the optical active layer is around 5 nm. We performed X-ray powder diffraction to confirm the cubic crystalline structure of the sesquioxides layer. High resolution transmission electron microscopy analyses corroborate the crystalline nature of the layer. The optical emission of Er³⁺ in the visible range has been recorded.     

Prototyping Dynamic Software Product Lines to evaluate run-time reconfigurations

Dynamic Software Product Lines (DSPL) encompass systems that are capable of modifying their own behavior with respect to changes in their operating environment by using run-time reconfigurations. A failure in these reconfigurations can directly impact the user experience since the reconfigurations are performed when the system is already under the users control. In this work, we prototype a Smart Hotel DSPL to evaluate the reliability-based risk of the DSPL reconfigurations, specifically, the probability of malfunctioning (Availability) and the consequences of malfunctioning (Severity). This DSPL prototype was performed with the participation of human subjects by means of a Smart Hotel case study which was deployed with real devices. Moreover, we successfully identified and addressed two challenges associated with the involvement of human subjects in DSPL prototyping: enabling participants to (1) trigger the run-time reconfigurations and to (2) understand the effects of the reconfigurations. The evaluation of the case study reveals positive results regarding both Availability and Severity. However, the participant feedback highlights issues with recovering from a failed reconfiguration or a reconfiguration triggered by mistake. To address these issues, we discuss some guidelines learned in the case study. Finally, although the results achieved by the DSPL may be considered satisfactory for its particular domain, DSPL engineers must provide users with more control over the reconfigurations or the users will not be comfortable with DSPLs.     

A kinetic interpretation of a negative time constant in impedance equivalent circuits for the dissolution/passive transition

A theoretical impedance function is proposed for the active/passive transition of nickel in an acid sulphate medium. It is considered that passivating species progressively covers the electrode surface. This approximated model predicts the appearance of negative time constants in the impedance spectra when coverage coefficient θ values for passive species are greater than 0.5.