Automatic verification of concurrent stochastic systems

Formal Methods in System Design - Automated verification techniques for stochastic games allow formal reasoning about systems that feature competitive or collaborative behaviour among rational...     

Optimization of the grapes reception process

Neural Computing and Applications - Grapes reception is a key process in wine production. The harvest days are extremely challenging days in managing the reception of the grapes, as the winery...     

Query language-based inverses of schema mappings: semantics, computation, and closure properties

The inversion of schema mappings has been identified as one of the fundamental operators for the development of a general framework for metadata management. During the last few years, three alternative notions of inversion for schema mappings have been proposed (Fagin-inverse (Fagin, TODS 32(4), 25:1–25:53, 2007), quasi-inverse (Fagin et?al., TODS 33(2), 11:1–11:52, 2008), and maximum recovery (Arenas et?al., TODS 34(4), 22:1–22:48, 2009)). However, these notions lack some fundamental properties that limit their practical applicability: most of them are expressed in languages including features that are difficult to use in practice, some of these inverses are not guaranteed to exist for mappings specified with source-to-target tuple-generating dependencies (st-tgds), and it has been futile to search for a meaningful mapping language that is closed under any of these notions of inverse. In this paper, we develop a framework for the inversion of schema mappings that fulfills all of the above requirements. It is based on the notion of ${\mathcal{C}}$ -maximum recovery, for a query language ${\mathcal{C}}$ , a notion designed to generate inverse mappings that recover back only the information that can be retrieved with queries in ${\mathcal{C}}$ . By focusing on the language of conjunctive queries (CQ), we are able to find a mapping language that contains the class of st-tgds, is closed under CQ-maximum recovery, and for which the chase procedure can be used to exchange data efficiently. Furthermore, we show that our choices of inverse notion and mapping language are optimal, in the sense that choosing a more expressive inverse operator or mapping language causes the loss of these properties.     

A framework for avoiding steganography usage over HTTP

Steganographic techniques allow users to covertly transmit information, hiding the existence of the communication itself. These can be used in several scenarios ranging from evading censorship to discreetly extracting sensitive information from an organization. In this paper, we consider the problem of using steganography through a widely used network protocol (i.e. HTTP). We analyze the steganographic possibilities of HTTP, and propose an active warden model to hinder the usage of covert communication channels. Our framework is meant to be useful in many scenarios. It could be employed to ensure that malicious insiders are not able to use steganography to leak information outside an organization. Furthermore, our model could be used by web servers administrators to ensure that their services are not being abused, for example, as anonymous steganographic mailboxes. Our experiments show that steganographic contents can be successfully eliminated, but that dealing with high payload carriers such as large images may introduce notable delays in the communication process.     

Preparation of grids for simulations of groundwater flow in fractured porous media

This work presents an extension of grid generation techniques for finite-volume discretizations of density-driven flow in fractured porous media, in which fractures are considered as low-dimensional manifolds and are resolved by sides of grid elements. The proposed technique introduces additional degrees of freedom for the unknowns assigned to the fractures and thus allows to reconstruct jumps of the solution over a fracture. Through the concept of degenerated elements, the proposed technique can be used for arbitrary junctions of fractures but is sufficiently simple regarding the implementation and allows for the application of conventional numerical solvers. Numerical experiments presented at the end of the paper demonstrate the applicability of this technique in two and three dimensions for complicated fracture networks.     

Methamphetamine Blocks Adenosine A2A Receptor Activation via Sigma 1 and Cannabinoid CB1 Receptors

Methamphetamine is, worldwide, one of the most consumed drugs of abuse. One important side effect is neurodegeneration leading to a decrease in life expectancy. The aim of this paper was to check whether the drug affects one of the receptors involved in neurodegeneration/neuroprotection events, namely the adenosine A_2A receptor (A_2AR). First, we noticed that methamphetamine does not affect A_2A functionality if the receptor is expressed in a heterologous system. However, A_2AR becomes sensitive to the drug upon complexes formation with the cannabinoid CB₁ receptor (CB₁R) and the sigma 1 receptor (σ₁R). Signaling via both adenosine A_2AR and cannabinoid CB₁R was affected by methamphetamine in cells co-expressing the two receptors. In striatal primary cultures, the A_2AR–CB₁R heteromer complex was detected and methamphetamine not only altered its expression but completely blocked the A_2AR- and the CB₁R-mediated activation of the mitogen activated protein kinase (MAPK) pathway. In conclusion, methamphetamine, with the participation of σ₁R, alters the expression and function of two interacting receptors, A_2AR, which is a therapeutic target for neuroprotection, and CB₁R, which is the most abundant G protein-coupled receptor (GPCR) in the brain.     

Fabry Disease and the Heart: A Comprehensive Review

Fabry disease (FD) is an X-linked lysosomal storage disorder caused by mutations of the GLA gene that result in a deficiency of the enzymatic activity of α-galactosidase A and consequent accumulation of glycosphingolipids in body fluids and lysosomes of the cells throughout the body. GB3 accumulation occurs in virtually all cardiac cells (cardiomyocytes, conduction system cells, fibroblasts, and endothelial and smooth muscle vascular cells), ultimately leading to ventricular hypertrophy and fibrosis, heart failure, valve disease, angina, dysrhythmias, cardiac conduction abnormalities, and sudden death. Despite available therapies and supportive treatment, cardiac involvement carries a major prognostic impact, representing the main cause of death in FD. In the last years, knowledge has substantially evolved on the pathophysiological mechanisms leading to cardiac damage, the natural history of cardiac manifestations, the late-onset phenotypes with predominant cardiac involvement, the early markers of cardiac damage, the role of multimodality cardiac imaging on the diagnosis, management and follow-up of Fabry patients, and the cardiac efficacy of available therapies. Herein, we provide a comprehensive and integrated review on the cardiac involvement of FD, at the pathophysiological, anatomopathological, laboratory, imaging, and clinical levels, as well as on the diagnosis and management of cardiac manifestations, their supportive treatment, and the cardiac efficacy of specific therapies, such as enzyme replacement therapy and migalastat.     

The Role of LGR4 (GPR48) in Normal and Cancer Processes

Leucine-rich repeats containing G protein-coupled receptor 4 (LGR4) is a receptor that belongs to the superfamily of G protein-coupled receptors that can be activated by R-spondins (RSPOs), Norrin, circLGR4, and the ligand of the receptor activator of nuclear factor kappa-B (RANKL) ligands to regulate signaling pathways in normal and pathological processes. LGR4 is widely expressed in different tissues where it has multiple functions such as tissue development and maintenance. LGR4 mainly acts through the Wnt/β-catenin pathway to regulate proliferation, survival, and differentiation. In cancer, LGR4 participates in tumor progression, invasion, and metastasis. Furthermore, recent evidence reveals that LGR4 is essential for the regulation of the cancer stem cell population by controlling self-renewal and regulating stem cell properties. This review summarizes the function of LGR4 and its ligands in normal and malignant processes.     

Detection of water ingress in composite sandwich structures: a magnetic resonance approach

Water ingress inside honeycomb sandwich panels during service has been linked to in-flight failure in some aircraft. There is an ongoing effort to develop nondestructive testing methods to detect the presence of water within the panels. Magnetic resonance (MR) represents an attractive approach in that it is sensitive to moisture. Using a unilateral MR sensor, testing can be applied directly to the surface of the panel. The viability of MR is demonstrated through laboratory imaging of both water within sandwich panels, as well as the adhesive itself. The detection of water using a one-sided handheld MR sensor is presented. It is shown that simple detection, as well as spatial localization of water within sandwich panels is possible.     

Comparison of a contactor catalytic membrane reactor with a conventional reactor: example of wet air oxidation

A wet air oxidation reaction was carried out in a gas/liquid catalytic membrane reactor of the contactor type. The oxidation of formic acid was used as a model reaction. The mesoporous top-layer of a ceramic tubular membrane was used as catalyst (Pt) support, and was placed at the interface of the gas (air) and liquid (HCOOH solution) phases.

A similar reaction was carried out in a conventional batch reactor, using a steering rate high enough to avoid gas-diffusion limitations, and exactly identical conditions than for the CMR (amount of catalyst, pressure, etc.). At room temperature, the CMR showed an initial activity three to six times higher than the conventional reactor. This activity increase was attributed to an easier oxygen access to the catalytic sites. Nevertheless, the catalytic membrane gradually deactivated after a few hours of operation. Different deactivation mechanisms are presented.