Leveraging decision‐making tools in capacity building planning: The Indonesian scientific network case

Abstract

The development of investment alternatives for the Government of Indonesia's proposed scientific network forms the background to this case. The goal was to rationalize a structure for developing and sustaining a broad‐based network capable of serving scientists throughout the country, including very remote areas. It became clear that one approach could combine both technological as well as entrepreneurial elements, since the data communications linkages for serving scientists could also be available for private customers. The process of defining and costing out this approach was a textbook example of a bottom‐up analysis, beginning with customer needs and working toward structures to satisfy the needs. The World Bank and the Government of Indonesia are in the process of implementing several features of the recommended system. The proposed approach can ultimately pay for itself through private sector revenues for user services. While the context of the decision is telecommunications, the methodology is appropriate for many decision‐making situations. Samples of actual data and bottom‐line results are discussed.     

State-of-the-art nanoplatform-integrated MALDI-MS impacting resolutions in urinary proteomics

Urine proteomics has become a subject of interest, since it has led to a number of breakthroughs in disease diagnostics. Urine contains information not only from the kidney and the urinary tract but also from other organs, thus urinary proteome analysis allows for identification of biomarkers for both urogenital and systemic diseases. The following review gives a brief overview of the analytical techniques that have been in practice for urinary proteomics. MALDI-MS technique and its current application status in this area of clinical research have been discussed. The review comments on the challenges facing the conventional MALDI-MS technique and the upgradation of this technique with the introduction of nanotechnology. This review projects nano-based techniques such as nano-MALDI-MS, surface-assisted laser desorption/ionization, and nanostructure-initiator MS as the platforms that have the potential in trafficking MALDI-MS from the lab to the bedside.     

Practical considerations for high spatial and temporal resolution dynamic transmission electron microscopy

Although recent years have seen significant advances in the spatial resolution possible in the transmission electron microscope (TEM), the temporal resolution of most microscopes is limited to video rate at best. This lack of temporal resolution means that our understanding of dynamic processes in materials is extremely limited. High temporal resolution in the TEM can be achieved, however, by replacing the normal thermionic or field emission source with a photoemission source. In this case the temporal resolution is limited only by the ability to create a short pulse of photoexcited electrons in the source, and this can be as short as a few femtoseconds. The operation of the photo-emission source and the control of the subsequent pulse of electrons (containing as many as 5 x 10(7) electrons) create significant challenges for a standard microscope column that is designed to operate with a single electron in the column at any one time. In this paper, the generation and control of electron pulses in the TEM to obtain a temporal resolution <10(-6)s will be described and the effect of the pulse duration and current density on the spatial resolution of the instrument will be examined. The potential of these levels of temporal and spatial resolution for the study of dynamic materials processes will also be discussed.     

The kinking behaviour of a bimaterial interface crack under indentation loading

The aims of this paper are twofold. The first is to evaluate the applicability of the formula for the crack kink angle—based on the maximum principle stress criterion—for predicting the interface kink angle in a bimaterial sample undergoing indentation loading. This formula was developed for cracks in homogenous materials but in this paper, it is used to predict the kink angle using the mode mixity at the tip of a crack lying on a bimaterial interface. The second aim is to examine the behaviour of the system, in terms of the crack kink angle and contact radius, for various coating thickness', crack lengths and combinations of properties of the coating and substrate. The system that is analysed consists of a planar bimaterial sample undergoing indentation with a tungsten-carbide spherical indenter. Two-dimensional, axisymmetric models are created to represent the system, with subdomains used for modelling the cracks. In order to determine the applicability of the kink angle formula, the angle predicted is compared to the angle that is directly calculated using boundary element method models that establish the angle of the kink which yields the maximum mechanical energy release rate. The second aim of the paper is achieved by varying the material property combinations and coating thickness of the bimaterial sample and observing the effect on the kink angle of the interface crack and the contact radius. The methodologies employed are initially verified on homogenous samples with known solutions.     

Influence of dietary protein on reproductive performance of dairy cows

From 10 +/- 3.5 d after parturition to 149 +/- 3.5 d of lactation, 146 cows (109 Holstein and 37 Ayrshires) were fed either a 15 or 20% crude protein diet of 45% sorghum silage and 55% concentrate. Milk production was enhanced by the 20% protein diet, but percentage of milk fat and protein were unchanged. Average daily intake of DM was unaffected by diet. Actual decreases in body weight and condition were small, although cows on 15% protein lost more condition. Concentration of plasma urea nitrogen increased rapidly during the first 4 wk of the experiment with cows on the 20% protein diet maintaining a 10 mg/dl advantage after the 4th wk on experiment. Diet did not affect the postpartum interval to first normal corpus luteum and standing estrus. Cows were inseminated artificially between 55 and 145 d post-calving with one freeze batch of semen from one bull of each appropriate breed mainly by one inseminator. Overall, days open, services per conception, and percentage cows pregnant on experiment were 80, 1.40, and 85, respectively. Concentration of protein in the diet did not affect these reproductive traits. There was no conflict between the amount of dietary protein provided for lactation and reproduction in this experiment.     

Reconciling user and project manager perceptions of IT project risk: a Delphi study1

Abstract. In an increasingly dynamic business environment characterized by fast cycle times, shifting markets and unstable technology, a business organization’s survival hinges on its ability to align IT capabilities with business goals. To facilitate the successful introduction of new IT applications, issues of project risk must be addressed, and the expectations of multiple stakeholders must be managed appropriately. To the extent that users and developers may harbour different perceptions regarding project risk, areas of conflict may arise. By understanding the differences in how users and project managers perceive the risks, insights can be gained that may help to ensure the successful delivery of systems. Prior research has focused on the project manager’s perspective of IT project risk. This paper explores the issue of IT project risk from the user perspective and compares it with risk perceptions of project managers. A Delphi study reveals that these two stakeholder groups have different perceptions of risk factors. Through comparison with a previous study on project manager risk perceptions, zones of concordance and discordance that must be reconciled are identified.     

The perceived urgency of speech warnings: semantics versus acoustics

The relationship between the semantics of words and the acoustics of the way they are spoken is explored. Actors spoke warning signal words in an urgent, nonurgent and monotone style, and participants rated the urgency of the words. Results showed effects for signal word and style of presentation. Acoustic analysis showed that the urgent words were spoken at higher frequency with a broader pitch range and were louder than the nonurgent or monotone words. These acoustic differences were used to synthesize artificial versions of signal words in urgent and nonurgent formats. The urgent words were rated as more urgent than the nonurgent words, a finding attributable to their differing acoustics. Within each speaking style the words were acoustically the same, yet effects for signal word were found, suggesting that semantics is also important in urgency perception. This research has implications for the design and implementation of speech warning systems, particularly those in which urgency mapping is required.     

Metal Residues in Farm-Raised Channel Catfish, Rainbow Trout, and Red Swamp Crayfish from the Southern U.S.

ABSTRACT: Farm-raised channel catfish (Ictalurus punctatus), rainbow trout (Oncorhynchus mykiss), and red swamp crayfish (Procambarus clarkii) were collected from production and processing sites across the southern U.S. and analyzed for barium, cadmium, copper, chromium, silver, lead, arsenic, selenium, and mercury. Average metal residues were much lower than recommended safety limits. Residues of barium, copper, and mercury were slightly higher in crayfish than catfish or trout. Selenium was higher in crayfish and trout than catfish, and lead was higher in catfish and trout than crayfish. Residues of mercury in all samples were much lower than the FDA's Action Limit (1 ppm) for mercury in the edible tissue of fish.     

Cryptococcosis in tree shrews (Tupaia tana and Tupaia minor) and elephant shrews (Macroscelides proboscides)

OBJECTIVE: To determine the relation between metabolic and anthropometric parameters and circulating leptin concentrations in women with polycystic ovary syndrome (PCOS). DESIGN AND PATIENTS: Correlation of fasting serum leptin concentrations with anthropometric measures and multiple metabolic parameters including insulin and glucose responses to a 2-hour 75-g oral glucose tolerance test (OGTT) in 85 women with PCOS (17-36 years, body mass index (BMI) 29.9 +/- 0.9 kg/m2, mean +/- SD) and 18 control women (25-47 years, BMI 25 +/- 1.7 kg/m2). Diagnostic criteria for PCOS: characteristic ovarian morphology on ultrasound plus at least two of (1) elevated serum testosterone; (2) elevated serum androstenedione; and (3) reduced serum SHBG concentrations. MEASUREMENTS: Concentrations of androgens, lipids, PRL, gonadotrophins, and leptin were measured in the baseline fasting blood sample from an OGTT. Insulin and glucose were measured throughout OGTT. Serum leptin concentrations were measured by radioimmunoassay. RESULTS: Log leptin levels in the PCOS group correlated significantly with BMI (r = 0.85, P < 0.0001) and with 8 other parameters including waist/hip ratio (r = 0.51, P = 0.0005). By stepwise regression analysis, only BMI (P < 0.0001) and plasma high density lipoprotein concentration (P = 0.02) were independently correlated with log leptin levels, both positively. There was no effect of fat distribution, as measured by waist/ hip ratio, on leptin concentrations. Comparison of control subjects to a BMI-matched subgroup of 55 PCOS subjects revealed significantly higher circulating concentrations of LH, testosterone, DHEAS, progesterone and androstenedione, and higher glucose and insulin responses to OGTT in the PCOS group. Leptin levels were not different between the PCOS subgroup and control group (14.8 +/- 1.3 vs 12.1 +/- 2.3 micrograms/l, mean +/- SE, P = 0.26) and the relation of BMI to leptin levels determined by linear regression analysis also did not differ between the two groups. CONCLUSIONS: Our results indicate that circulating leptin concentrations in women with PCOS, a condition characterized by hyperandrogenaemia, increased LH concentrations and insulin resistance, are strongly related to BMI and not independently affected by circulating levels of insulin, gonadotrophins or sex hormones.     

Social dominance mediates the association of testosterone and neurobehavioral disinhibition with risk for substance use disorder.

This investigation determined the influence of testosterone and neurobehavioral disinhibition (ND) on risk for substance use disorder (SUD). Testosterone level during puberty was hypothesized to promote social dominance associated with norm-violating behavior that, in turn, predisposes individuals to use of illicit drugs and, subsequently, SUD. Using a prospective paradigm, the authors recruited 179 boys (mean age=11.62 years, SD=0.88) and followed up when participants were ages 12-14, 16, 19, and 22. Results indicated that social dominance/norm-violating behavior (SD/NVB) at age 16 mediated the association between testosterone level (ages 12-14) and SUD (age 22). In addition, SD/NVB mediated the association between ND and SUD. These findings suggest that development of SUD is influenced by androgen-dependent and neurobehavioral processes via a social motivational style characterized by SD/NVB. (PsycINFO Database Record (c) 2010 APA, all rights reserved)