Pre-Transplant Serum Leptin Levels and Relapse of Acute Myeloid Leukemia after Allogeneic Transplantation

Weight loss and metabolic activity influence outcome after allogeneic stem cell transplantation (alloSCT). This study evaluates pre-conditioning Leptin, a peptide hormone involved in metabolism and immune homeostasis, as a prognostic factor for survival, relapse and non-relapse mortality (NRM) following alloSCT. Leptin serum levels prior to conditioning were determined in a cohort of patients transplanted for various hematologic malignancies (n = 524) and correlated retrospectively with clinical outcome. Findings related to patients with acute leukemia (AL) from this sample were validated in an independent cohort. Low pre-conditioning serum Leptin was an independent prognostic marker for increased risk of relapse (but not of NRM and overall mortality) following alloSCT for AL of intermediate and advanced stage (beyond first complete remission). Multivariate analysis revealed a hazard ratio (HR) for relapse of 0.75 per log2 increase (0.59–0.96, p = 0.020). This effect was similar in an independent validation cohort. Pre-conditioning serum Leptin was validated as a prognostic marker for early relapse by fitting the multivariate Cox model to the validation data. Pre-conditioning serum Leptin levels may serve as an independent prognostic marker for relapse following alloSCT in intermediate and advanced stage AL patients. Prospective studies are required to prove whether serum Leptin could be used for guiding nutritional intervention in patients with AL undergoing alloSCT.     

住宅建筑外墙外保温系统的应用

介绍正在施工中的上海世博会动迁区域的浦江住宅小区的外墙外保温技术。作为环保型住宅建筑,外保温系统的设计与施工是“长住久安”的保证,其中基层处理、抗裂层处理、饰面层处理及节点处理不容小觑。     

在近海吹填土基上打入预制桩的施工质量控制

在临海滩涂地质条件极差的情况下,采用重机下铺路基箱进行来回碾压,而后将表层土翻挖再施以重力排水．使场地条件得以改善,也使打入预制桩的施工质量得到了有效的控制。     

天然气超音速分离脱水技术研究进展

超音速分离技术在国外的研究与应用已经成熟,但国内的研究仍处于探索阶段.现已开展了较多的基础性研究和数值模拟研究,其中数值模拟研究主要集中在旋流流动过程、内部流动过程和凝结过程等方面,并取得一定成果,但实验性研究仍然较少,特别是在高压天然气的凝结机理及分离机理方面,未见工业性试验和现场测试试验的报道.在结构设计方面做了大...     

Partial Label Learning via Conditional-Label-Aware Disambiguation

Partial label learning is a weakly supervised learning framework in which each instance is associated with multiple candidate labels,among which only one is the ground-truth label.This paper proposes a unified formulation that employs proper label constraints for training models while simultaneously performing pseudo-labeling.Unlike existing partial label learning approaches that only leverage similarities in the feature space without utilizing label constraints,our pseudo-labeling process leverages similarities and differences in the feature space using the same candidate label constraints and then disambiguates noise labels.Extensive experiments on artificial and real-world partial label datasets show that our approach significantly outperforms state-of-the-art counterparts on classification prediction.     

多功能太阳能充电小车的设计与实现

以S T C89C51单片机为控制核心,采用太阳能板、L298N电机驱动芯片、T C R T5000红外传感器和H C-S R04超声波传感器为主要元器件,设计一种多功能太阳能充电小车,通过光电转化,实现小车前进后退、转向变速、太阳能充电以及循迹避障等多项控制功能.     

新型α+β双相钛合金板抗高速冲击损伤行为研究

采用直径7.5 mm钢丸对新型Ti-Mo-V系α+β双相钛合金板材进行高速冲击试验,使用光学显微镜及扫描电镜,对等轴组织板材抗高速冲击损伤行为进行分析。结果表明：钢丸高速冲击后,损伤部位均未观察到明显的分区现象。冲击着板瞬间,相比于钢丸垂直高速冲击,钢丸冲击方向与板法线方向存在较小偏角时,板材更易发生高速冲击破坏失效,沿板材正面冲击损伤中轴线侧剖后可观察到非对称形态的冲击损伤。冲击损伤部位均形成绝热剪切带,主要分布在正面冲击损伤部位中心及两侧区域,其分布形式主要包括：(1)在冲击损伤中心处呈半弧状分布;(2)在冲击损伤部位两侧沿高速冲击方向约呈45°分布,绝热剪切失效是板材防护失效的主要原因。     

基于线阵CCD的纠偏系统设计与实现

为了解决自动化生产流水线上物料在传送、收放卷过程中的偏差问题,本文设计了一种自动纠偏系统.该系统以线阵CCD作为传感器,以ARM作为控制器,以电机和滚珠丝杠作为执行机构,具有纠偏方式多样性,纠偏精度高和系统实时性高等优点.同时借助于LCD和GUI,实现了系统参数的图形化设置,系统运行状态的直观显示和纠偏基准位置的简单设定.实验表明,系统的响应时间不大于10 ms,系统纠偏精度达到0.2 mm,可适用于各种需要纠偏的场合.     

基于LabVIEW的环境试验设备温湿度检定系统

为了实现对环境试验设备的检定,以LabVIEW为开发语言,Aligent34970A(配34901A模块)为数据采集器,RS232为通信方式,依据环境试验设备温度、湿度校准规范(JJF1101-2003),开发了环境试验设备温湿度检定系统;文章中讲述了系统的硬件组成和软件设计及数据采集、数据后续处理和系统的整体架构;并选用A级Pt100四线制铂热电阻检定环境温度,进行了升温、保温和测量阶段的实验,在Word中生成报表及校准结果,结果符合标准要求;该系统已在实际中得到应用,并取得了很好的效果。     

相位补偿型电光A/D转换器的优化设计

提出了一种可以提高泰勒型电光A/D转换器有效位的方案,其原理是用相位补偿的直接转向波导或分支波导代替传统的S-弯曲波导.采用有限差分束传输法设计出由质子交换工艺制作的高折射率微棱镜进行相位补偿的4位电光A/D转换器的波导结构,利用保角变换方法对调制电极参数进行优化.最后得到优化结构参数为设计4-6位的高速电光A/D转换器提供了理论依据,同时也得到了一些对实际设计有一定指导意义的结论.