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Thermal behaviour of poly(lactic acid) in contact with compressed carbon dioxide

BACKGROUND: The thermal behaviour of poly(lactic acid) (PLA) in contact with compressed CO₂ was studied using high‐pressure differential scanning calorimetry. In particular, the effect of annealing below and above the glass transition temperature (T_g) on the glass transition, cold crystallization and melting temperatures was studied systematically as a function of annealing time and pressure. RESULTS: The effect of compressed CO₂ on the thermal properties of PLA is time dependent. Annealing below T_g decreases the temperature and enthalpy of cold crystallization. Similar, but more evident, behaviours are observed when annealing above T_g. Crystallization temperature and enthalpy during cooling decrease with increasing pressure, and the peak is narrower. CONCLUSION: Annealing PLA in the presence of compressed CO₂ accelerates cold crystallization, but retards crystallization during cooling. Copyright © 2009 Society of Chemical Industry     

Dynamics and fragmentation of thick-shelled microbubbles

Localized delivery could decrease the systemic side effects of toxic chemotherapy drugs. The unique delivery agents we examine consist of microbubbles with an outer lipid coating, an oil layer, and a perfluorobutane gas core. These structures are 0.5-12 /spl mu/m in radius at rest. Oil layers of these acoustically active lipospheres (AALs) range from 0.3-1.5 /spl mu/m in thickness and thus the agents can carry a large payload compared to nano-scale drug delivery systems. We show that triacetin-based drug-delivery vehicles can be fragmented using ultrasound. Compared with a lipid-shelled contrast agent, the expansion of the drug-delivery vehicle within the first cycle is similar, and a subharmonic component is demonstrated at an equivalent radius, frequency, and driving pressure. For the experimental conditions explored here, the pulse length required for destruction of the drug-delivery vehicle is significantly greater, with at least five cycles required, compared with one cycle for the contrast agent. For the drug-delivery vehicle, the observed destruction mechanism varies with the initial radius, with microbubbles smaller than resonance size undergoing a symmetric collapse and producing a set of small, equal-sized fragments. Between resonance size and twice resonance size, surface waves become visible, and the oscillations become asymmetrical. For agents larger than twice the resonance radius, the destruction mechanism changes to a pinch-off, with one fragment containing a large fraction of the original volume.     

Nondestructive subharmonic imaging

Ultrasound contrast agent microbubbles are intravascular agents that can be used to estimate blood perfusion. Blood perfusion may be estimated by destroying the bubbles in a vascular bed and observing the refresh of contrast agents back into the vascular bed. Contrast agents can be readily destroyed by traditional imaging techniques. The design of a nondestructive imaging technique is necessary for the accurate quantification of contrast agent refresh. In this work, subharmonic imaging is investigated as a method for nondestructive imaging with the contrast agent microbubble MP1950 (Mallinckrodt, Inc., St. Louis, MO). Optical observation during insonation, in conjunction with a modified Rayleigh-Plesset (R-P) analysis, provides insight into the mechanisms of and parameters required for subharmonic frequency generation. Subharmonic imaging with a transmission frequency that is the same as the resonant frequency of the bubble is shown to require a minimum pressure of insonation that is greater than the experimentally-observed bubble destruction threshold. Subharmonic imaging with a transmission frequency that is twice the resonant frequency of the bubble produces a subharmonic frequency response while minimizing bubble instability. Optimization is performed using optical experimental analysis and R-P analysis     

Bayesian super-resolution of text in videowith a text-specific bimodal prior

To increase the range of sizes of video scene text recognizable by optical character recognition (OCR), we developed a Bayesian super-resolution algorithm that uses a text-specific bimodal prior. We evaluated the effectiveness of the bimodal prior, compared and in conjunction with a piecewise smoothness prior, visually and by measuring the accuracy of the OCR results on the variously super-resolved images. The bimodal prior improved the readability of 4- to 7-pixel-high scene text significantly better than bicubic interpolation and increased the accuracy of OCR results better than the piecewise smoothness prior.     

Chemical composition of fuels and emissions from a coal + tire combustion experiment in a power station

Medium-sulfur bituminous coal and a mixture of 95 wt.% coal plus 5 wt.% tire-derived fuel (TDF) in the form of shredded automotive tires were combusted in a stoker boiler under the same conditions. This paper presents quantitative chemical compositions of the fuels and of the gaseous and particulate emissions. The coal + TDF mixture is considerably richer in Zn than the pure coal as a result of the high Zn content of the shredded tires (∼1 wt.% Zn). Atmospheric emissions of Zn increased from 15 g/h to nearly 2.4 kg/h when coal + TDF was combusted. Similarly, emissions of most other metals and metalloids, as well as those of HCl increased when TDF (∼3000 ppm Cl) was added. The enhanced metal emissions might be due to formation of gaseous metal chloride species in the stack gases. On the other hand, emissions of CO decreased slightly, whereas those of NO_x, SO₂, and total particulate matter remained virtually unchanged. These results help in assessing the environmental impact of energy recovery from scrap tires in stoker boilers.     

Managing fddi networks: The state of the standards

The third in a serieson the FDDI standard, this article looksatSMT–the Fibre Distributed Data Interface Station Management–and the directions for FDDI over copper cables.     

Preparing for Program Accreditation Review Under ABET Engineering Criteria 2000: Choosing Outcome Indicators

This paper examines a variety of outcome indicators that might be used by an engineering program in meeting the assessment requirements of ABET Engineering Criteria 2000. Several categories of indicator are identified and key characteristics of these means of assessment are discussed. Also noted are some of the engineering applications of outcome indicators documented on the World Wide Web. Finally, the results of a recent telephone/fax survey on the use of outcome indicators in engineering program assessment are summarized.     

A method for radiation-force localized drug delivery using gas-filled lipospheres

We have developed a method using ultrasound and acoustically active lipospheres (AALs) that might be used to deliver bioactive substances to the vascular endothelium. The AALs consist of a small gas bubble surrounded by a thick oil shell and enclosed by an outermost lipid layer. The AALs are similar to ultrasound contrast agents: they can be nondestructively deflected using ultrasound radiation force, and fragmented with high-intensity ultrasound pulses. The lipid-oil complex might be used to carry bioactive substances at high concentrations. An optimized sequence of ultrasound pulses can deflect the AALs toward a vessel wall then disrupt them, painting their contents across the vascular endothelium. This paper presents results from a series of in vitro and ex vivo experiments demonstrating localization of a fluorescent model drug. In experiments using a human melanoma cell (A2085) monolayer, a specific radiation force-fragmentation ultrasound pulse sequence increased cell fluorescence more than 10-fold over no ultrasound or fragmentation pulses alone, and by 50% over radiation force pulses alone. We observe that dye transfer is limited to cells that are in the region of ultrasonic focus, indicating that the application of radiation force pulses to bring the delivery vehicle into proximity with the cell is required for successful adhesion of the vehicle fragments to the cell membrane. We also demonstrate dye transfer from flowing AALs, both in a mimetic vessel and in excised rat cecum. We believe that this method could be successfully used for drug delivery in vivo.