Cranial Base Synchondrosis Lacks PTHrP-Expressing Column-Forming Chondrocytes

The cranial base contains a special type of growth plate termed the synchondrosis, which functions as the growth center of the skull. The synchondrosis is composed of bidirectional opposite-facing layers of resting, proliferating, and hypertrophic chondrocytes, and lacks the secondary ossification center. In long bones, the resting zone of the epiphyseal growth plate houses a population of parathyroid hormone-related protein (PTHrP)-expressing chondrocytes that contribute to the formation of columnar chondrocytes. Whether PTHrP⁺ chondrocytes in the synchondrosis possess similar functions remains undefined. Using Pthrp-mCherry knock-in mice, we found that PTHrP⁺ chondrocytes predominantly occupied the lateral wedge-shaped area of the synchondrosis, unlike those in the femoral growth plate that reside in the resting zone within the epiphysis. In vivo cell-lineage analyses using a tamoxifen-inducible Pthrp-creER line revealed that PTHrP⁺ chondrocytes failed to establish columnar chondrocytes in the synchondrosis. Therefore, PTHrP⁺ chondrocytes in the synchondrosis do not possess column-forming capabilities, unlike those in the resting zone of the long bone growth plate. These findings support the importance of the secondary ossification center within the long bone epiphysis in establishing the stem cell niche for PTHrP⁺ chondrocytes, the absence of which may explain the lack of column-forming capabilities of PTHrP⁺ chondrocytes in the cranial base synchondrosis.     

Electrochemical superabrasive machining of a nickel-based aeroengine alloy using mounted grinding points

Brief design and manufacture considerations are detailed for a hybrid electrochemical grinding unit adapted from a vertical machining centre using a 40,000 rpm spindle and 500 A DC generator. Subsequently, experimental work is presented on the influence of tool bond systems, superabrasive grit type and electrical parameters when simultaneous ECM/grinding Udimet 720 using 10-15 mm diameter plain points. Single layer electroplated CBN tools produced G-ratios and maximum normal cutting forces of ∼451 and ∼45 N, respectively, compared to ∼128 and 557 N for equivalent diamond wheels. Data on workpiece roughness and overcut are also presented as are initial results for a fir tree shaped tool.     

Determination of the antioxidant capacity: influence of the sample concentration on the measured values

The aim of the present analysis was to study the influence of the sample concentration on the measured antioxidant capacity, since such investigations are scarce but necessary to ensure the reproducibility of the results. Pure substances (ascorbic acid, gallic acid, Trolox^®, uric acid) and food extracts (strawberry nectar, tomato extract, white tea) were analysed using seven common antioxidant capacity assays (three versions of Trolox equivalent antioxidant capacity, TEAC; ferric reducing antioxidant power, FRAP; photochemiluminescence, PCL; oxygen radical absorbance capacity, ORAC and total phenolics assay). For all applied pure substances and in most of the assays effects of the sample concentration on the measured antioxidant capacity were observed. Since it remains speculative how sample concentration does affect the measured antioxidant capacity exactly, it is strongly recommended to use at least three sample concentrations for analysis to detect and to discuss concentration-dependent effects.     

Social influence effects on automatic racial prejudice.

Although most research on the control of automatic prejudice has focused on the efficacy of deliberate attempts to suppress or correct for stereotyping, the reported experiments tested the hypothesis that automatic racial prejudice is subject to common social influence. In experiments involving actual interethnic contact, both tacit and expressed social influence reduced the expression of automatic prejudice, as assessed by two different measures of automatic attitudes. Moreover, the automatic social tuning effect depended on participant ethnicity. European Americans (but not Asian Americans) exhibited less automatic prejudice in the presence of a Black experimenter than a White experimenter (Experiments 2 and 4), although both groups exhibited reduced automatic prejudice when instructed to avoid prejudice (Experiment 3). Results are consistent with shared reality theory, which postulates that social regulation is central to social cognition. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Sixteen-channel coherent broadcast network at 155 Mbit/s

An experimental 155.52 Mb/s coherent broadcast network with 16 channels using a conventional distributed feedback (DFB) laser operating at 1540 nm is described. It includes absolute laser frequency stabilization, a fiber span of 74.4 km, and a balanced polarization-diversity single-filter frequency-shift keying (FSK) heterodyne receiver. At a channel spacing of 8.5 GHz a power penalty of 0.3 dB is incurred due to adjacent channel crosstalk     

ADSORPTION OF ASPHALTS AND THEIR SIZE EXCLUSION CHROMATOGRAPHY FRACTIONS ON AGGREGATE SURFACES

The adsorption behavior of two asphalts and their size exclusion chromatography (SEC) fractions from toluene solution onto aggregate was investigated. The effect of the differences in chemistry and molecular size of the asphalt samples on their adsorption behavior on silica, granite and greywacke was determined. The adsorption of asphalts and SEC fractions on SI-1000 silica was well-represented by the Toth model, while the Radke-Prausnitz model better described their adsorption behavior on both granite and greywacke. Combining the adsorption models with the Gibbs adsorption equation of state gave the spreading pressure of each adsorbate species adsorbed on the aggregate surfaces. The spreading pressure predicted the competitive adsorptive edge of the asphalt fractions. The SEC I fractions, containing molecules of larger molecular size and higher heteroatom contents, showed higher spreading pressures than the SEC II fractions, which contained molecules of smaller molecular size and fewer heteroatoms. The asphalts yielded intermediate spreading pressures for SI-1000 silica and granite, but they gave the highest spreading pressure values for greywacke.     

Transmitted power variations in single-mode fiber joints withobliquely polished endfaces

An experimental and theoretical study of multiple-beam interference effects at oblique endface airgap joints, with endfaces oriented parallel to each other, is discussed. It was found that although excellent return loss performance can be obtained by using such joints, large variations in the transmitted power can result in small changes in endface separation. Compared to the case of nonoblique endfaces, endface separation between the successive fringes in oblique endfaces increases by a factor which depends on the oblique angle and the refractive index of the gap material     

Multiple predictor smoothing methods for sensitivity analysis: Example results

The use of multiple predictor smoothing methods in sampling-based sensitivity analyses of complex models is investigated. Specifically, sensitivity analysis procedures based on smoothing methods employing the stepwise application of the following nonparametric regression techniques are described in the first part of this presentation: (i) locally weighted regression (LOESS), (ii) additive models, (iii) projection pursuit regression, and (iv) recursive partitioning regression. In this, the second and concluding part of the presentation, the indicated procedures are illustrated with both simple test problems and results from a performance assessment for a radioactive waste disposal facility (i.e., the Waste Isolation Pilot Plant). As shown by the example illustrations, the use of smoothing procedures based on nonparametric regression techniques can yield more informative sensitivity analysis results than can be obtained with more traditional sensitivity analysis procedures based on linear regression, rank regression or quadratic regression when nonlinear relationships between model inputs and model predictions are present.     

On the impact performance of carbon fibre laminates with epoxy and PEEK matrices

A study was made of the mechanical properties and impact performance of carbon fibre/PEEK (0,90), ($\text{±45}$) and ($\text{±45,0}$) laminates and comparisons were made with similar carbon fibre/epoxy laminatesFibre dominated properties such as plain tensile strength were similar to those of epoxy laminates with similar fibres and volume fractions. Because of the increased toughness of PEEK there was less extensive matrix cracking, even though there was fibre debonding, and this gave increased transverse and shear cracking strains, increased shear strengths but decreased notched tensile strengths. The lower modulus and yield stress of PEEK caused lower compressive strengths, but PEEK absorbed little moisture and at 120°C moisture had little effect on mechanical properties.Dropweight impact produced less extensive damage in carbon fibre/PEEK laminates. Residual tensile strengths were similar but, because of the less extensive damage and greater delamination fracture energy, the residual compressive strengths were significantly greater with a PEEK matrix.Microscopic examination showed less matrix cracking and more fibre buckling in the carbon fibre/PEEK and this is discussed in relation to mechanical properties.     

Assessing landscape preferences: a visual choice experiment in the agricultural region of Märkische Schweiz,Germany

Natural amenities and the aesthetic value of agricultural landscapes are important territorial assets for improving rural tourism and the quality of the living environment. To identify which characteristics shape the visual quality of a landscape, a stated-preference survey was conducted (N = 200) using photorealistic landscape visualisations of four different landscape attributes (point green elements, linear green elements, crop diversity and presence of livestock). We estimated respondents’ preferences for landscape attributes, examined the extent of agreement among respondents and identified socio-economic factors influencing their responses. Results revealed that point elements had the highest general preference. About 70% of respondents preferred diverse and highly structured landscapes, while about 30% of respondents had opposing preferences. Preferences were also found to be dependent on the individual’s sociocultural background, such as their level of education, gender or age. These results can help to improve the multi-objective targeting of policies by including an aesthetic value perspective.