Relationship between age and clinical characteristics of patients with gastric cancer

The relationship between the prognosis and age of patients with gastric cancer is controversial. To evaluate whether there is a biological characteristic specific to the age of patients, we examined the clinical characteristics of patients with gastric cancer with special reference to their age. Based on a prospective database, a retrospective study of 419 patients who underwent radical gastrectomy for cure in the past 6 years was conducted. Clinical characteristics including gender, gross appearance of the tumour (Borrmann's classification, tumour location), histopathology (depth of tumour invasion, lymph node status, Lauren's classification and degree of tumour cell differentiation) and TNM tumour stage were analysed in six different age groups (< 39, 40-49, 50-59, 60-69, 70-79, > 80 years). The mean age of the 419 patients was 64.6 years (range from 26-91) and the peak age incidence of gastric cancer (46.3%) was in the 60-69 year old age group. The male: female ratio was 4.6:1 on the whole and male gender predominated at ages > 60. The proportion of diffuse type tumours (68.4%) by Lauren's criteria in the young age group (< 39 yrs) decreased with age (25% in the > 80 years group; P < 0.001). Similarly, the proportion of poorly-differentiated tumours (89.5%) in the young age group (< 39 yrs) decreased with advancing age (P < 0.001). These findings suggest that both diffuse type and poorly-differentiated tumours predominate in younger patients and, without considering the factor of delay in diagnosis, may explain the poorer prognosis demonstrated in younger patients.     

Untoward effects of blood transfusion: common problems and simple safeguards

Potential transfusion reactions include hemolysis, disease transmission (particularly hepatitis), allergic and febrile reactions, and symptoms of circulatory overload. Limiting the number of transfusions given to patients for whom the procedure will achieve some clearly defined clinical goal is one way of reducing the number of adverse reactions. When transfusion is to be carried out, great care should be taken in correctly identifying both patient and blood to avoid ABO mix-ups, and thorough pretransfusion laboratory testing should be done. During and after transfusion the patient should be closely observed for complications.     

Age and sex as factors influencing remission duration in African Burkitt's lymphoma

The frequency of Burkitt's lymphoma peaks in children six to nine years of age and is twice as high in males as in females. To determine if age or sex had any relationship to outcome of therapy, the authors examined the experience of 387 patients treated for Burkitt's lymphoma at the Burkitt Tumor Project, Accra, Ghana, between 1966 and 1978. No age or sex relationship could be demonstrated with overall survival. However, among children without central nervous system disease who achieved an initial remission, the relapse rates were higher for those diagnosed initially in the age interval 6-9 years than for those diagnosed at younger or older ages. This pattern was seen for each stage of the disease as well as overall. Sex did not influence relapse rate. The relationship of these findings to the Epstein-Barr virus and malaria, both suspected factors in the etiology of this disease, is discussed, but neither appears to explain our results.     

Conservative therapy of angina pectoris using nifedipine (Adalat)

35 patients with angina pectoris or previous myocardial infarction were treated for the period of 6 weeks with a new calcium-antagonist (4-2'-Nitrophenyl-2,6-Dimethyl 1,4-dihydro-pyridin-3,5-dicarbon acid dimethylester) Adalat. The attacks of angina pectoris decreased by 75 percent, the need for nitroglycerin decreased by 84 percent. Examination at rest and under exercise before and during the treatment with Adalat showed when registered by electrocardiogram and by the mean pulmonary-capillary pressure a better tolerance under exercise during treatment as well as a decrease of the PCPm in rest and under exercise after 6 week-therapy with Adalat. No improvement during the period of treatment was seen in 2 patients, who suffered from a severe diffuse type of coronary artery disease.     

Gabapentin treatment of mood disorders: a preliminary study

OBJECTIVE: To determine if gabapentin is effective either as adjunctive treatment or as monotherapy for major affective disorders in a naturalistic setting. METHOD: All charts of patients meeting DSM-IV criteria for bipolar disorder or unipolar major depressive disorder treated with gabapentin in a private psychiatric practice were reviewed and clinical response was assessed retrospectively using the Clinical Global Impressions scale for Improvement (CGI-I). RESULTS: Gabapentin was moderately to markedly effective in 30% (15/50) of patients, with statistically nonsignificant differences between patients with bipolar disorder type I, bipolar disorder type II and NOS, and unipolar major depressive disorder. 70% reported side effects, mainly sedation, with 16% of the total sample discontinuing treatment due to adverse events. CONCLUSION: Gabapentin appears to be somewhat effective as add-on treatment in a subgroup of patients with mood disorders in a naturalistic setting. Prospective, controlled studies are required to clarify these pilot data.     

Cooperative Caching in Wireless Multimedia Sensor Networks

The recent advances in miniaturization and the creation of low-power circuits, combined with small-sized batteries have made the development of wireless sensor networks a working reality. Lately, the production of cheap complementary metal-oxide semiconductor cameras and microphones, which are able to capture rich multimedia content, gave birth to what is called Wireless Multimedia Sensor Networks (WMSNs). WMSNs will boost the capabilities of current wireless sensor networks, and will fuel several novel applications, like multimedia surveillance sensor networks. WMSNs introduce several new research challenges, mainly related to mechanisms to deliver application-level Quality-of-Service (e.g., latency minimization). To address this goal in an environment with extreme resource constraints, with variable channel capacity and with requirements for multimedia in-network processing, the caching of multimedia data, exploiting the cooperation among sensor nodes is vital. This article presents a cooperative caching solution particularly suitable for WMSNs. The proposed caching solution exploits sensor nodes which reside in “positions” of the network that allow them to forward packets or communicate decisions within short latency. These so-called “mediator” nodes are selected dynamically, so as to avoid the creation of hot-spots in the communication and the depletion of their energy. The mediators are not more powerful than the rest of the nodes, but they have some special role in implementing the cooperation among the sensors. The proposed cooperative caching protocol includes components for locating cached data as well as for implementing data purging out of the sensor caches. The proposed solution is evaluated extensively in an advanced simulation environment, and it is compared to the state-of-the-art cooperative caching algorithm for mobile ad hoc networks. The results confirm that the proposed caching mechanism prevails over its competitor.     

Effect of high-pressure treatment at various temperatures on indigenous proteolytic enzymes and whey protein denaturation in bovine milk

The objective of the present study was to determine the effect of high pressure (HP) processing (200, 450 and 650 MPa) at various temperatures (20, 40 and 55 degrees C) on the total plasmin plus plasminogen-derived activity (PL), plasminogen activator(s) (PA) and cathepsin D activities and on denaturation of major whey proteins in bovine milk. Data indicated that transfer of both PL and PA from the casein micelles to milk serum occurred at all pressures utilized at room temperature (20 degrees C). In addition to the transfer of PL and PA from micelles, there were reductions in activities of PL (16-18%) and PA (38-62%) for the pressures 450 and 650 MPa, at room temperature. There were synergistic negative effects between pressure and temperature on residual PL activity at 450 and 650 MPa and on residual PA activity only at 450 MPa. Cathepsin D activity in the acid whey from HP-treated milk was in general baroresistant at room temperature. The residual activity of cathepsin D decreased significantly at 650 MPa and 40 degrees C and at the pressures 450 and 650 MPa at 55 degrees C. Synergistic negative effects on the amount of native beta-lactoglobulin were observed at 450 and 650 MPa and on the amount of native alpha-lactalbumin at 650 MPa. There were significant correlations between enzymatic activities (PL, PA and cathepsin D) and the residual native beta-lactoglobulin and alpha-lactalbumin in bovine milk. In conclusion, HP significantly affected the activity of indigenous proteolytic enzymes and whey protein denaturation in bovine milk. Reduction in activity of indigenous enzymes (PL, PA and cathepsin D) and transfer of PL and PA from the casein to milk serum induced by HP is expected to have a profound effect on cheese yield, proteolysis during cheese ripening and quality of UHT milk during storage.     

Multifunctional devices and logic gates with undoped silicon nanowires

We report on the electronic transport properties of multiple-gate devices fabricated from undoped silicon nanowires. Understanding and control of the relevant transport mechanisms was achieved by means of local electrostatic gating and temperature-dependent measurements. The roles of the source/drain contacts and of the silicon channel could be independently evaluated and tuned. Wrap gates surrounding the silicide-silicon contact interfaces were proved to be effective in inducing a full suppression of the contact Schottky barriers, thereby enabling carrier injection down to liquid helium temperature. By independently tuning the effective Schottky barrier heights, a variety of reconfigurable device functionalities could be obtained. In particular, the same nanowire device could be configured to work as a Schottky barrier transistor, a Schottky diode, or a p-n diode with tunable polarities. This versatility was eventually exploited to realize a NAND logic gate with gain well above one.