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41.
A super-peer semantic network defines the semantic groups that client peers and their super peers use to connect with each
other according to the semantic similarity of shared documents in peers. This will result in a query that can be evaluated
locally thus reducing query process time and the amount of communication required to obtain related data. In this study, new
algorithms are proposed to arrange shared documents in peers into hierarchical cluster tree structures, and links will be
set up to connect semantically related super peers. During query evaluation, only related peers will be searched thus the
complexity of computing is significantly reduced. Consideration is also given to automatically deciding the threshold for
clustering and the construction and other essential operations for hierarchical cluster trees. The experiment results illustrate
the features of the approach developed in this study. 相似文献
42.
Hobbie KA Peterson ES Barton ML Waters KM Anderson KA 《Journal of laboratory automation》2012,17(4):275-283
Large collaborative centers are a common model for accomplishing integrated environmental health research. These centers often include various types of scientific domains (e.g., chemistry, biology, bioinformatics) that are integrated to solve some of the nation's key economic or public health concerns. The Superfund Research Center (SRP) at Oregon State University (OSU) is one such center established in 2008 to study the emerging health risks of polycyclic aromatic hydrocarbons while using new technologies both in the field and laboratory. With outside collaboration at remote institutions, success for the center as a whole depends on the ability to effectively integrate data across all research projects and support cores. Therefore, the OSU SRP center developed a system that integrates environmental monitoring data with analytical chemistry data and downstream bioinformatics and statistics to enable complete "source-to-outcome" data modeling and information management. This article describes the development of this integrated information management system that includes commercial software for operational laboratory management and sample management in addition to open-source custom-built software for bioinformatics and experimental data management. 相似文献
43.
Linh Thao Ly Stefanie Rinderle-Ma Kevin G?ser Peter Dadam 《Information Systems Frontiers》2012,14(2):195-219
Key to broad use of process management systems (PrMS) in practice is their ability to foster and ease the implementation,
execution, monitoring, and adaptation of business processes while still being able to ensure robust and error-free process
enactment. To meet these demands a variety of mechanisms has been developed to prevent errors at the structural level (e.g., deadlocks). In many application domains, however, processes often have to comply with business level rules and
policies (i.e., semantic constraints) as well. Hence, to ensure error-free executions at the semantic level, PrMS need certain control mechanisms for validating
and ensuring the compliance with semantic constraints. In this paper, we discuss fundamental requirements for a comprehensive
support of semantic constraints in PrMS. Moreover, we provide a survey on existing approaches and discuss to what extent they
are able to meet the requirements and which challenges still have to be tackled. In order to tackle the particular challenge
of providing integrated compliance support over the process lifecycle, we introduce the SeaFlows framework. The framework
introduces a behavioural level view on processes which serves a conceptual process representation for constraint specification
approaches. Further, it provides general compliance criteria for static compliance validation but also for dealing with process
changes. Altogether, the SeaFlows framework can serve as formal basis for realizing integrated support of semantic constraints
in PrMS. 相似文献
44.
45.
The results of two experiments showed that an illusion of memory can be produced by unconscious perception. In a first phase of those experiments, a long list of words was presented for study. For the test of recognition memory given in the second phase of each experiment, presentation of a "context" word preceded that of most recognition test words. Ss were to judge whether or not the test words had been presented during the earlier study phase of the experiment. Effects of a context word on this recognition memory decision were opposite when Ss were aware vs. unaware of its presentation. For example, as compared to a condition in which no context word was presented, the probability of false recognition was increased when Ss were unaware but decreased when Ss were aware of the presentation of a context word that matched the recognition test word. Results are discussed in terms of unconscious influences on an attribution process. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
46.
Maria B. Asparuhova Alexandra Sthli Kevin Guldener Anton Sculean 《International journal of molecular sciences》2021,22(8)
The aim of the present study was to investigate the influence of a novel volume-stable collagen matrix (vCM) on early wound healing events including cellular migration and adhesion, protein adsorption and release, and the dynamics of the hemostatic system. For this purpose, we utilized transwell migration and crystal violet adhesion assays, ELISAs for quantification of adsorbed and released from the matrix growth factors, and qRT-PCR for quantification of gene expression in cells grown on the matrix. Our results demonstrated that primary human oral fibroblasts, periodontal ligament, and endothelial cells exhibited increased migration toward vCM compared to control cells that migrated in the absence of the matrix. Cellular adhesive properties on vCM were significantly increased compared to controls. Growth factors TGF-β1, PDGF-BB, FGF-2, and GDF-5 were adsorbed on vCM with great efficiency and continuously delivered in the medium after an initial burst release within hours. We observed statistically significant upregulation of genes encoding the antifibrinolytic thrombomodulin, plasminogen activator inhibitor type 1, thrombospondin 1, and thromboplastin, as well as strong downregulation of genes encoding the profibrinolytic tissue plasminogen activator, urokinase-type plasminogen activator, its receptor, and the matrix metalloproteinase 14 in cells grown on vCM. As a general trend, the stimulatory effect of the vCM on the expression of antifibrinolytic genes was synergistically enhanced by TGF-β1, PDGF-BB, or FGF-2, whereas the strong inhibitory effect of the vCM on the expression of profibrinolytic genes was reversed by PDGF-BB, FGF-2, or GDF-5. Taken together, our data strongly support the effect of the novel vCM on fibrin clot stabilization and coagulation/fibrinolysis equilibrium, thus facilitating progression to the next stages of the soft tissue healing process. 相似文献
47.
Kevin Munoz Samiksha Wasnik Amir Abdipour Hongzheng Bi Sean M. Wilson Xiaolei Tang Mahdis Ghahramanpouri David J. Baylink 《International journal of molecular sciences》2021,22(10)
Acute lung injury (ALI) afflicts approximately 200,000 patients annually and has a 40% mortality rate. The COVID-19 pandemic has massively increased the rate of ALI incidence. The pathogenesis of ALI involves tissue damage from invading microbes and, in severe cases, the overexpression of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). This study aimed to develop a therapy to normalize the excess production of inflammatory cytokines and promote tissue repair in the lipopolysaccharide (LPS)-induced ALI. Based on our previous studies, we tested the insulin-like growth factor I (IGF-I) and BTP-2 therapies. IGF-I was selected, because we and others have shown that elevated inflammatory cytokines suppress the expression of growth hormone receptors in the liver, leading to a decrease in the circulating IGF-I. IGF-I is a growth factor that increases vascular protection, enhances tissue repair, and decreases pro-inflammatory cytokines. It is also required to produce anti-inflammatory 1,25-dihydroxyvitamin D. BTP-2, an inhibitor of cytosolic calcium, was used to suppress the LPS-induced increase in cytosolic calcium, which otherwise leads to an increase in proinflammatory cytokines. We showed that LPS increased the expression of the primary inflammatory mediators such as toll like receptor-4 (TLR-4), IL-1β, interleukin-17 (IL-17), TNF-α, and interferon-γ (IFN-γ), which were normalized by the IGF-I + BTP-2 dual therapy in the lungs, along with improved vascular gene expression markers. The histologic lung injury score was markedly elevated by LPS and reduced to normal by the combination therapy. In conclusion, the LPS-induced increases in inflammatory cytokines, vascular injuries, and lung injuries were all improved by IGF-I + BTP-2 combination therapy. 相似文献
48.
The Lovász ?-function (Lovász in IEEE Trans. Inf. Theory, 25:1–7, 1979) of a graph G=(V,E) can be defined as the maximum of the sum of the entries of a positive semidefinite matrix X, whose trace Tr(X) equals 1, and X ij =0 whenever {i,j}∈E. This function appears as a subroutine for many algorithms for graph problems such as maximum independent set and maximum clique. We apply Arora and Kale’s primal-dual method for SDP to design an algorithm to approximate the ?-function within an additive error of δ>0, which runs in time $O(\frac{\vartheta ^{2} n^{2}}{\delta^{2}} \log n \cdot M_{e})$ , where ?=?(G) and M e =O(n 3) is the time for a matrix exponentiation operation. It follows that for perfect graphs G, our primal-dual method computes ?(G) exactly in time O(? 2 n 5logn). Moreover, our techniques generalize to the weighted Lovász ?-function, and both the maximum independent set weight and the maximum clique weight for vertex weighted perfect graphs can be approximated within a factor of (1+?) in time O(? ?2 n 5logn). 相似文献
49.
Robert A. Moreau David B. Johnston Kevin B. Hicks 《Journal of the American Oil Chemists' Society》2007,84(11):1039-1044
All commercial corn oil is obtained by pressing corn germ and/or extracting the germ with hexane. In the current study, six
types of corn oil were prepared by extracting corn germ, corn fiber and ground corn, each with hexane or with ethanol. The
levels of lutein, zeaxanthin and other carotenoids were quantitatively analyzed in the six corn oils. The levels of lutein + zeaxanthin
in the oil ranged from 2.3 μg/g for hexane-extracted corn germ oil to 220.9 μg/g for ethanol-extracted ground corn oil. These
results indicate that a diet that includes 30 g (~2 tbsp) per day of the unrefined corn oil obtained by extracting ground
corn with ethanol would provide ~6 mg of lutein + zeaxanthin, the daily dosage that is currently considered to be necessary
to slow the progression of age-related macular degeneration.
Mention of trade names or commercial products in this publication is solely for the purpose of providing specific information
and does not imply recommendation or endorsement by the U.S. Department of Agriculture. 相似文献
50.
Lianhang Ma Hao Huang Qinming He Kevin Chiew Zhenguang Liu 《Journal of Intelligent Information Systems》2014,43(1):183-203
Local community detection aims at finding a community structure starting from a seed which is a given vertex in a network without global information, such as online social networks that are too large and dynamic to ever be known fully. Nonetheless, the existing approaches to local community detection are usually sensitive to seeds, i.e., some seeds may lead to missing of some true communities. In this paper, we present a seed-insensitive method called GMAC and its variation iGMAC for local community detection. They estimate the similarity among vertices by investigating vertices’ neighborhoods, and reveal a local community by maximizing its internal similarity and minimizing its external similarity simultaneously. Extensive experimental results on both synthetic and real-world data sets verify the effectiveness of our algorithms. 相似文献