Comparison of the action potential prolonging and positive inotropic activity of DPI 201-106 and BDF 9148 in human ventricular myocardium

The aim of our study was to compare the effects on contractile function and action potential duration of the new Na+ channel modulator BDF 9148 with the parent compound DPI 201-106 in human ventricular myocardium. Right ventricular papillary muscles were obtained from explanted hearts of heart transplant recipients or from non-failing hearts not suitable for transplantation. BDF 9148 induced an increase in force of contraction that was accompanied by prolongation of action potential duration. The action potential duration prolonging effect of BDF 9148 was not significantly different to that of DPI 201-106. The effects of BDF 9148 were similar in muscles obtained from non-failing and failing hearts. Using Na(+)-sensitive electrodes, we have demonstrated that the positive inotropic effect of BDF 9148 is accompanied by an increase in intracellular Na+ activity. Our results indicate: (i) that BDF 9148 is as effective as DPI 201-106 in increasing force of contraction and prolonging action potential duration in human ventricular myocardium: (ii) that BDF 9148 is effective in enhancing force of contraction, in spite of heart failure; (iii) that the positive inotropic effect is related to an increased Na+ load; and (iv) due to action potential duration prolongation, changes in Q-T interval of the electrocardiogram could be possible during in vivo use of BDF 9148.     

Crises telephone services.

Discusses the proliferation of crisis telephone services, which are usually staffed by nonprofessionals. When psychologists offer their services to these organizations, they are usually met with resentment. Perhaps the best role for psychologists would be assisting in training the volunteers. Training methods include didactic sessions and role playing. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Automated detection of unusual events on stairs

This paper presents a method for automatically detecting unusual human events on stairs from video data. The motivation is to provide a tool for biomedical researchers to rapidly find the events of interest within large quantities of video data. Our system identifies potential sequences containing anomalies, and reduces the amount of data that needs to be searched by a human. We compute two sets of features from a video of a person descending a stairwell. The first set of features are the foot positions and velocities. We track both feet using a mixed state particle filter with an appearance model based on histograms of oriented gradients. We compute expected (most likely) foot positions given the state of the filter at each frame. The second set of features are the parameters of the mean optical flow over a foreground region. Our final classification system inputs these two sets of features into a hidden Markov model (HMM) to analyse the spatio-temporal progression of the stair descent. A single HMM is trained on sequences of normal stair use, and a threshold on sequence likelihoods is used to detect unusual events in new data. We demonstrate our system on a data set with five people descending a set of stairs in a laboratory environment. We show how our system can successfully detect nearly all anomalous events, with a low false positive rate. We discuss limitations and suggest improvements to the system.     

High cycle fatigue of welded joints: The TCD experience

This paper reports on the use of two methods for the prediction of high cycle fatigue failure in welded joints. The development of these methods – known as the crack modelling method and the theory of critical distances – is described, summarising previously published work on test specimens using steels and aluminium alloys. It is concluded that the methods work well, predicting fatigue strength with errors of less than 20% in the great majority of cases. Certain types of joint were found to give rise to large, conservative errors, but similar errors also occurred when using other, well established, methods of prediction. Some restrictions also arise with the use of the TCD for bodies having very small section thicknesses. Finally, two case studies, described here for the first time, illustrate the issues that arise when making predictions during investigations into the failure of welded joints in real engineering components in service.     

Aerosol flow through a long micro-capillary: collimated aerosol beam

A micro-capillary system capable of generating a focused collimated aerosol beam (CAB) is demonstrated both theoretically and experimentally. The approach is based on a manifestation of the Saffman force where high velocity (∼100 m/s) aerosol particles, flowing through a micro-capillary (d ∼ 100 μm and l ∼ 1 cm), migrate perpendicular to the centerline of the capillary. Upon exiting the micro-capillary system, the particles maintain momentum, and when the aerosol is comprised of solid-in-liquid dispersions such as Ag nanoparticle ink, the CAB approach enables printing of advanced materials features with linewidth ≤ 10 μm.