Objective: To investigate the modulation of the wettability of excipients by different types of surfactants and its impacts on the disintegration of tablets and drug release.
Materials and methods: The critical micelle concentration (CMC) of surfactants, including sodium dodecyl sulfate (SDS), sodium dodecyl benzene sulfonate (SDBS), dodecyl trimethyl ammonium bromide (DTAB), cetyltrimethyl ammonium bromide (CTAB) and polysorbate (Tween-20 and Tween-80), was obtained using the platinum ring method. Contact angles of surfactant solutions on the excipient compacts and double-distilled water on the mixture of surfactant and the other excipient (magnesium stearate (MgSt) or sodium alginate (SA)) were measured by the sessile drop technique. Besides, surface free energy of excipients was calculated by the Owens method. Finally, the disintegration of tablets and in vitro dissolution testing were performed according to the method described in USP.
Results and discussion: The wettability of excipients could be enhanced to different extent with low concentration of surfactant solutions and maintained stable basically after CMC. For MgSt (hydrophobic excipient), the shorter the hydrophobic chain (C12, including SDS and DTAB), the better the wettability with the addition of surfactant in the formulation, leading to the shorter disintegration time of tablets and higher drug release rate. In contrast, the wettability of SA (hydrophilic excipient) was reduced by adding surfactant, resulting in the longer disintegration time of tablets and lower release rate.
Conclusion: The modulation of the wetting of pharmaceutical excipients by surfactant had changed the disintegration time of tablets and drug release rate to a greater extent. 相似文献
La1?xAgxFeO3/halloysites nanotubes (HNTs) nanocomposite was synthesized by sol–gel method. It was characterized by X-ray diffraction, transmission electron microscope, Fourier transform infrared spectroscopy and UV–visible diffused reflectance spectroscopy measurements. The photo-activity of the La1?xAgxFeO3/HNTs nanocomposite was evaluated via degradation of methylene blue (MB) under visible-light irradiation. The results showed that the HNTs with unique pore structure favored the adsorption of organic molecules. Adequate Ag+ doping improved the absorption ability for visible light. The La0.95Ag0.05FeO3/HNTs demonstrated the best photocatalytic performance, which achieved as high as 99 % for MB degradation exposed 2 h irradiation. However,further increasing of Ag+ doping gradually reduced the photocatalytic activity. The nanocomposite catalyst showed outstanding recyclability after eight cycles which still remained up to 90 %. 相似文献