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131.
132.
Luis Magdalena 《国际智能系统杂志》2002,17(5):471-493
133.
Susanna C. Scholtz & Magdalena J. C. Bosman 《International Journal of Food Science & Technology》2005,40(8):857-866
The acceptance of, preference for and consumption intent for high‐fibre muffins and/or rusks baked with either red palm olein (RPO) or sunflower oil (SFO, as control) were evaluated by two consumer groups of 144 and 67 consumers, respectively, in order to determine the possibility of their successful inclusion as carriers for oils in a subsequent nutrition intervention trial. A five‐point hedonic and food action rating scale was used for sensory evaluation. SFO muffins and rusks scored significantly higher than RPO products on a number of hedonic dimensions and were thus more acceptable to the average consumer. Sensory attributes of SFO and RPO products received high scores by consumers from both groups (≥4.0 on five‐point scale), and consumers intended to eat them often (at least one per day). The RPO products were satisfactory in terms of acceptance and complied with requirements for use in the subsequent nutrition intervention trial. 相似文献
134.
Magdalena Rohrbeck JProf. Dr. Christian Fischer Prof. Dr. Stefan Wehner Dr. Jutta Meier Prof. Dr. Werner Manz 《真空研究与实践》2014,26(2):42-47
Polymers made of renewable resources increasingly replace conventional plastic materials made of petroleum. Socalled bioplastics can be found e. g. in food industry, for agricultural usage or in the medical field. The range of applications can be further expanded with specialized coating of their surface. Especially in case of food packaging and the usage within medical devices as well as the storage of these composite materials, sterilization or at least the partial reduction of microbial growth is an important issue which needs to be addressed early in the production process. In this work, a commercially available polyhydroxyalkanoate (PHA) pure bioplastic foil of 50 μm thickness was coated with 100 nm of diamond‐like carbon (DLC) and afterwards treated by four different standard methods of sterilization and / or disinfection, namely deep‐freezing, ultraviolet irradiation, autoclaving and immersion in ethanol. The surface morphology of treated DLC‐coated and uncoated samples was investigated and compared to the untreated DLC‐coated and uncoated samples using scanning electron microscopy (SEM) and atomic force microscopy (AFM). Measurements exhibited damage of the composite for autoclaved and in ethanol immersed samples, whereas deep‐frozen and ultraviolet irradiated samples showed no structural changes. These findings clearly demonstrate deep‐freezing and ultraviolet irradiation to be appropriate methods for the disinfection and sterilization, respectively, of the DLC‐coated pure bioplastic foil. 相似文献
135.
136.
Soluch W Brzozowski E Lysakowska M Sadura J 《IEEE transactions on ultrasonics, ferroelectrics, and frequency control》2011,58(11):2469-2474
Mass density, dielectric, elastic, and piezoelectric constants of bulk GaN crystal were determined. Mass density was obtained from the measured ratio of mass to volume of a cuboid. The dielectric constants were determined from the measured capacitances of an interdigital transducer (IDT) deposited on a Z-cut plate and from a parallel plate capacitor fabricated from this plate. The elastic and piezoelectric constants were determined by comparing the measured and calculated SAW velocities and electromechanical coupling coefficients on the Z- and X-cut plates. The following new constants were obtained: mass density p = 5986 kg/m(3); relative dielectric constants (at constant strain S) ε(S)(11)/ε(0) = 8.6 and ε(S)(11)/ε(0) = 10.5, where ε(0) is a dielectric constant of free space; elastic constants (at constant electric field E) C(E)(11) = 349.7, C(E)(12) = 128.1, C(E)(13) = 129.4, C(E)(33) = 430.3, and C(E)(44) = 96.5 GPa; and piezoelectric constants e(33) = 0.84, e(31) = -0.47, and e(15) = -0.41 C/m(2). 相似文献
137.
Kinga Gostomska-Pampuch Jacek R. Winiewski Karol Sowiski Wieslaw I. Gruszecki Andrzej Gamian Magdalena Staniszewska 《International journal of molecular sciences》2022,23(21)
MAGE (melibiose-derived advanced glycation end-product) is the glycation product generated in the reaction of a model protein with melibiose. The in vivo analog accumulates in several tissues; however, its origin still needs explanation. In vitro MAGE is efficiently generated under dry conditions in contrast to the reaction carried in an aqueous solvent. Using liquid chromatography coupled with mass spectrometry, we analyzed the physicochemical properties and structures of myoglobin glycated with melibiose under different conditions. The targeted peptide analysis identified structurally different AGEs, including crosslinking and non-crosslinking modifications associated with lysine, arginine, and histidine residues. Glycation in a dry state was more efficient in the formation of structures containing an intact melibiose moiety (21.9%) compared to glycation under aqueous conditions (15.6%). The difference was reflected in characteristic fluorescence that results from protein structural changes and impact on a heme group of the model myoglobin protein. Finally, our results suggest that the formation of in vitro MAGE adduct is initiated by coupling melibiose to a model myoglobin protein. It is confirmed by the identification of intact melibiose moieties. The intermediate glycation product can further rearrange towards more advanced structures, including cross-links. This process can contribute to a pool of AGEs accumulating locally in vivo and affecting tissue biology. 相似文献
138.
Cosmin Vasilica Pricope Bogdan Ionel Tamba Gabriela Dumitrita Stanciu Magdalena Cuciureanu Anca Narcisa Neagu Ioana Creanga-Murariu Bogdan-Ionut Dobrovat Cristina Mariana Uritu Silviu Iulian Filipiuc Bianca-Mariana Pricope Teodora Alexa-Stratulat 《International journal of molecular sciences》2022,23(21)
Chronic neuropathic pain (CNP) affects around 10% of the general population and has a significant social, emotional, and economic impact. Current diagnosis techniques rely mainly on patient-reported outcomes and symptoms, which leads to significant diagnostic heterogeneity and subsequent challenges in management and assessment of outcomes. As such, it is necessary to review the approach to a pathology that occurs so frequently, with such burdensome and complex implications. Recent research has shown that imaging methods can detect subtle neuroplastic changes in the central and peripheral nervous system, which can be correlated with neuropathic symptoms and may serve as potential markers. The aim of this paper is to review available imaging methods used for diagnosing and assessing therapeutic efficacy in CNP for both the preclinical and clinical setting. Of course, further research is required to standardize and improve detection accuracy, but available data indicate that imaging is a valuable tool that can impact the management of CNP. 相似文献
139.
Magdalena Kotaska Anna Dziubina Magorzata Szafarz Kamil Mika Marek Bednarski Noemi Nicosia Ahmed Temirak Christa E. Müller Katarzyna Kie-Kononowicz 《International journal of molecular sciences》2022,23(21)
The adenosine A2A and A2B receptors are promising therapeutic targets in the treatment of obesity and diabetes since the agonists and antagonists of these receptors have the potential to positively affect metabolic disorders. The present study investigated the link between body weight reduction, glucose homeostasis, and anti-inflammatory activity induced by a highly potent and specific adenosine A2B receptor antagonist, compound PSB-603. Mice were fed a high-fat diet for 14 weeks, and after 12 weeks, they were treated for 14 days intraperitoneally with the test compound. The A1/A2A/A2B receptor antagonist theophylline was used as a reference. Following two weeks of treatment, different biochemical parameters were determined, including total cholesterol, triglycerides, glucose, TNF-α, and IL-6 blood levels, as well as glucose and insulin tolerance. To avoid false positive results, mouse locomotor and spontaneous activities were assessed. Both theophylline and PSB-603 significantly reduced body weight in obese mice. Both compounds had no effects on glucose levels in the obese state; however, PSB-603, contrary to theophylline, significantly reduced triglycerides and total cholesterol blood levels. Thus, our observations showed that selective A2B adenosine receptor blockade has a more favourable effect on the lipid profile than nonselective inhibition. 相似文献
140.
Anna Sykua Adriana Nowak Eugenio Garribba Aliaksandr Dzeikala Magdalena Rowiska-yrek Justyna Czerwiska Waldemar Maniukiewicz Elbieta odyga-Chruciska 《International journal of molecular sciences》2023,24(1)
The three Schiff base ligands, derivatives of hesperetin, HHSB (N-[2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-ylidene]isonicotinohydrazide), HIN (N-[2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-ylidene]benzhydrazide) and HTSC (N-[2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-ylidene]thiosemicarbazide) and their copper complexes, CuHHSB, CuHIN, and CuHTSC were designed, synthesized and analyzed in terms of their spectral characterization and the genotoxic activity. Their structures were established using several methods: elemental analysis, FT-IR, UV-Vis, EPR, and ESI-MS. Spectral data showed that in the acetate complexes the tested Schiff bases act as neutral tridentate ligand coordinating to the copper ion through two oxygen (or oxygen and sulphur) donor atoms and a nitrogen donor atom. EPR measurements indicate that in solution the complexes keep their structures with the ligands remaining bound to copper(II) in a tridentate fashion with (O–, N, Oket) or (O–, N, S) donor set. The genotoxic activity of the compounds was tested against model tumour (HeLa and Caco-2) and normal (LLC-PK1) cell lines. In HeLa cells the genotoxicity for all tested compounds was noticed, for HHSB and CuHHSB was the highest, for HTSC and CuHTSC–the lowest. Generally, Cu complexes displayed lower genotoxicity to HeLa cells than ligands. In the case of Caco-2 cell line HHSB and HTSC induced the strongest breaks to DNA. On the other side, CuHHSB and CuHTSC induced the highest DNA damage against LLC-PK1. 相似文献