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81.
Franois Van Laethem Lucie Donaty Emmanuelle Tchernonog Vanessa Lacheretz-Szablewski Jennifer Russello Delphine Buthiau Marion Almeras Jrme Moreaux Caroline Bret 《International journal of molecular sciences》2022,23(24)
Leukocyte-associated immunoglobulin (Ig)-like receptor 1 (LAIR1, CD305) belongs to the family of immune-inhibitory receptors and is widely expressed on hematopoietic mature cells, particularly on immune cells. Four different types of ligands of LAIR1 have been described, including collagens, suggesting a potential immune-regulatory function on the extracellular matrix. By modulating cytokine secretion and cellular functions, LAIR1 displays distinct patterns of expression among NK cell and T/B lymphocyte subsets during their differentiation and cellular activation and plays a major negative immunoregulatory role. Beyond its implications in physiology, the activity of LAIR1 can be inappropriately involved in various autoimmune or inflammatory disorders and has been implicated in cancer physiopathology, including hematological neoplasms. Its action as an inhibitory receptor can result in the dysregulation of immune cellular responses and in immune escape within the tumor microenvironment. Furthermore, when expressed by tumor cells, LAIR1 can modulate their proliferation or invasion properties, with contradictory pro- or anti-tumoral effects depending on tumor type. In this review, we will focus on its role in normal physiological conditions, as well as during pathological situations, including hematological malignancies. We will also discuss potential therapeutic strategies targeting LAIR1 for the treatment of various autoimmune diseases and cancer settings. 相似文献
82.
Elodie Mareux Martine Lapalus Amel Ben Saad Renaud Zelli Mounia Lakli Yosra Riahi Marion Almes Manon Banet Isabelle Callebaut Jean-Luc Decout Thomas Falguires Emmanuel Jacquemin Emmanuel Gonzales 《International journal of molecular sciences》2022,23(18)
ABCB11 is responsible for biliary bile acid secretion at the canalicular membrane of hepatocytes. Variations in the ABCB11 gene cause a spectrum of rare liver diseases. The most severe form is progressive familial intrahepatic cholestasis type 2 (PFIC2). Current medical treatments have limited efficacy. Here, we report the in vitro study of Abcb11 missense variants identified in PFIC2 patients and their functional rescue using cystic fibrosis transmembrane conductance regulator potentiators. Three ABCB11 disease-causing variations identified in PFIC2 patients (i.e., A257V, T463I and G562D) were reproduced in a plasmid encoding an Abcb11-green fluorescent protein. After transfection, the expression and localization of the variants were studied in HepG2 cells. Taurocholate transport activity and the effect of potentiators were studied in Madin–Darby canine kidney (MDCK) clones coexpressing Abcb11 and the sodium taurocholate cotransporting polypeptide (Ntcp/Slc10A1). As predicted using three-dimensional structure analysis, the three variants were expressed at the canalicular membrane but showed a defective function. Ivacaftor, GLP1837, SBC040 and SBC219 potentiators increased the bile acid transport of A257V and T463I and to a lesser extent, of G562D Abcb11 missense variants. In addition, a synergic effect was observed when ivacaftor was combined with SBC040 or SBC219. Such potentiators could represent new pharmacological approaches for improving the condition of patients with ABCB11 deficiency due to missense variations affecting the function of the transporter. 相似文献
83.
Marion W. Blair 《Journal of the American Ceramic Society》1927,10(6):464-466
Several methods of introducing barium to clay bodies are discussed. These include addition (1) in a wet dilute solution, (2) in a wet concentrated solution, (3) dry by sprinkling on to the raw clay in the car before grinding. (4) dry to the dry pan or crusher in proportion to the speed of the machine. (5) dry from a disk feeder applying the clay to the pug mill. 相似文献
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86.
ML Forbes KS Hendrich PM Kochanek DS Williams JK Schiding SR Wisniewski SF Kelsey ST DeKosky SH Graham DW Marion C Ho 《Canadian Metallurgical Quarterly》1997,17(8):865-874
We measured CBF and CO2 reactivity after traumatic brain injury (TBI) produced by controlled cortical impact (CCI) using magnetic resonance imaging (MRI) and spin-labeled carotid artery water protons as an endogenous tracer. Fourteen Sprague-Dawley rats divided into TBI (CCI; 4.02 +/- 0.14 m/s velocity; 2.5 mm deformation), sham, and control groups were studied 24 hours after TBI or surgery. Perfusion maps were generated during normocarbia (Paco2 30 to 40 mm Hg) and hypocarbia (PaCO2 15 to 25 mm Hg). During normocarbia, CBF was reduced within a cortical region of interest (ROI, injured versus contralateral) after TBI (200 +/- 82 versus 296 +/- 65 mL.100 g-1.min-1, P < 0.05). Within a contusion-enriched ROI, CBF was reduced after TBI (142 +/- 73 versus 280 +/- 64 mL.100 g-1.min-1, P < 0.05). Cerebral blood flow in the sham group was modestly reduced (212 +/- 112 versus 262 +/- 118 mL.100 g-1.min-1, P < 0.05). Also, TBI widened the distribution of CBF in injured and contralateral cortex. Hypocarbia reduced cortical CBF in control (48%), sham (45%), and TBI rats (48%) versus normocarbia, P < 0.05. In the contusion-enriched ROI, only controls showed a significant reduction in CBF, suggesting blunted CO2 reactivity in the sham and TBI group. CO2 reactivity was reduced in the sham (13%) and TBI (30%) groups within the cortical ROI (versus contralateral cortex). These values were increased twofold within the contusion-enriched ROI but were not statistically significant. After TBI, hypocarbia narrowed the CBF distribution in the injured cortex. We conclude that perfusion MRI using arterial spin-labeling is feasible for the serial, noninvasive measurement of CBF and CO2 reactivity in rats. 相似文献
87.
Jrme Serri Marion Martiny Grard Ferron 《International Journal of Mechanical Sciences》2005,47(6):884-901
This paper aims at investigating the effects of the martensitic phase transformation on the formability of unstable austenitic steel sheets. To this end, the constitutive model developed by Iwamoto and Tsuta (International Journal of Plasticity 2002;18:1583–606) has been implemented in the user's material subroutine of the finite element code Abaqus/Explicit. The different contributions of the martensitic transformation to the overall plastic behaviour are analysed with the aim of assessing their influence in sheet-metal forming. The effects of transformation strains, and of the stress-state dependence of the kinetics of phase transformation are critically discussed in the case of the cup drawing test. The simulation results are also compared with experimental cup tests from the literature. 相似文献
88.
This paper presents a modified YCN cryptographic key assignment scheme in a hierarchy with exceptions which is secure against Hwang's attack. 相似文献
89.
PD Adelson B Clyde PM Kochanek SR Wisniewski DW Marion H Yonas 《Canadian Metallurgical Quarterly》1997,26(4):200-207
PURPOSE: Endotoxin (lipopolysaccharide [LPS])-induced systemic organ injury leads to disruption of normal systemic organ metabolic processes, which are manifest clinically by signs of accelerated anaerobic metabolism (e.g., tissue acidosis and hyperlactatemia) and altered VO2-DO2 relationships. The association of increased anaerobic metabolism with VO2-DO2 alterations has led to the notion that ischemia/ reperfusion (I/R) injury may be a prerequisite for the development of VO2-DO2 alterations during endotoxemia. However, in contrast to sepsis, in which oxygen consumption is often increased, oxygen consumption is severely decreased after I/R injury. Based on these observations, we hypothesized that I/R injury would result in systemic organ VO2-DO2 alterations, which are distinct from those that occur in sepsis. MATERIALS AND METHODS: We used the in situ autoperfused feline ileal preparation to simultaneously examine microvascular permeability, reflected as the ileal lymph to plasma protein concentration ratio (CL/CP), and ileal VO2-DO2 relationships after either intravenous LPS (2.0 mg/kg; n = 5) or I/R injury (n = 5), and in matching controls (n = 5). RESULTS: As expected, all LPS-treated and I/R-injured animals were found to have extensive ileal histological damage and marked increases in the CL/CP compared with controls (0.315 +/- 0.009 and 0.329 +/- 0.034, respectively, v 0.097 +/- 0.009; P < .001, both comparisons). In addition, the critical DO2 (DO2c) was elevated, and the critical oxygen extraction was decreased in both the I/R and LPS groups relative to controls. However, as initially hypothesized, the VO2 at the critical DO2 was markedly decreased in the I/R group compared with that of the LPS group. CONCLUSIONS: These data indicate that I/R injury is insufficient to account for the systemic organ VO2-DO2 alterations that occur with LPS injury. 相似文献
90.
A system of rules based on neuropsychological test data and the 2nd author's 4 methods of inference (level of performance, right–left differences, patterns of performance, and pathognomonic signs) was developed for classifying 3 samples (19 Ss each) of 9–14 yr old children as normal, learning disabled, or brain damaged. The 37 rules used a 4-point scaled scoring system with 0 representing adequate performance, 3 indicating distinctly abnormal performance, and 1 and 2 indicating intermediate performance. The rules system classified children into the 3 groups (normal, learning disabled, and brain damaged) with 73.3% accuracy. Although in need of replication, results indicate that the rules system is sensitive to neuropsychological differences between these groups and represents a set of initial guidelines for differentiating among normal, brain-damaged, and learning disabled children. Results also support the contention that learning disability often represents a degree of cerebral dysfunction that is frequently undetected by neurological examination but that can be reliably measured by neuropsychological tests. (9 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献