The measurement of gastric motor function and transit in man by echo planar magnetic resonance imaging

Echo-planar imaging (EPI) can be used to produce snapshot images of the human stomach and antro-pyloro-duodenal segment in real time as an alternative technique to intubation and exposure to ionizing radiation. The method has been further developed to monitor simultaneous gastric motility and gastric emptying of liquid and solid meals. The model has been utilized to study the effects of pharmacological agents on gastric function.Eight normal subjects were imaged in a 0.5-T superconducting magnet for up to 6 h following ingestion of 800 ml tap water, followed by 500 ml porridge test meal + 500 ml tap water. A rapid multislice technique was adopted to image adjacent transverse slices (10 mm thick) through the gastric region. In addition, three subjects were orally dosed with 20 mg of the prokinetic agent Cisapride. Gastric volumes for each slice were calculated and summed to produce a measure of total gastric volume and gastric emptying. Contractile activity at the level of the antro-pyloric segment was detected using sequential 128 ms images at 3 s intervals. Alternate measurements of gastric volume and motility were made for the duration of the study.Gastric emptyingT _1/2's (times to empty 50% of the gastric contents) of 12.9 min for water and 116 min for porridge were in agreement with results obtained by the traditional techniques of gamma scintigraphy and impedance imaging. The frequency of gastric contractions increased from 2.4 contractions per minute (cpm) to 3.2 cpm following water and from 2.9 to 3.2 cpm following porridge. The prokinetic effect of enhanced coordination of antroduodenal contractions was also observed. These studies have demonstrated that EPI can be used to detect and image gastroduodenal function in man, totally noninvasively, and can be used to study the effects of drugs acting on the gastrointestinal tract.     

The effect of high temperature plastic flow on the superconducting transition in A15 compounds

Low temperature heat capacity measurements have been made on hot isostatically pressed Nb₃Sn and arc cast, homogenized, and A15 transformation annealed V-23.3 at. pct Ga and V-18.1 at. pct Ga. The heat capacity measurements display the superconducting transition temperature (T _c), and have been used to evaluate the effects of plastic deformation on theT _c range. Plastic deformation to the extent of 15 pct compression at 1525 and 1650 °C does not alter the superconducting transition in polycrystalline Nb₃Sn. Plastic deformation to the extent of 15 pct compression at 1050 and 1200 °C does not alter the superconducting transition in polycrystalline V-23.3Ga, transformed to A15 structure with a fifty-hour 1150 °C anneal. The same statement can be made for A15 V-18.1Ga, deformed at 1050 °C after a fifty-hour, 1150 °C anneal. With onlyfive hours annealing at 1150 °C, A15 V-23.2Ga displays a lowering and broadening of theT _c range upon 1050 and 1200 °C plastic deformation. With onlyfive hours annealing at 1150 °C, A15 V-18.1Ga displays a broad, but increasedT _c range after plastic deformation at 1050 °C.     

Loss of control, self-blame, and depression: An investigation of spouse caregivers of Alzheimer's disease patients.

Tested several predictions derived from the reformulated learned helplessness (RLH) depression model developed by L. Y. Abramson et al (see record 1979-00305-001) and from recent critiques of that model, in a longitudinal study of spouses caring for a husband or wife with Alzheimer's disease. During initial interviews, 68 caregivers (aged 37–85 yrs) rated the uncontrollability of important upsetting events related to their spouse's disease and were scored on an index of internal–external causal attribution (CATN) for those events. In addition, at both the initial and follow-up interviews (n?=?38) about 10 mo later, caregivers were rated for depression, anxiety, and hostility. Results indicate that the indices of loss of control and CATN were more consistently related to depression than to anxiety or hostility, although hostility was related to CATNs. Correlations of the loss of control and CATN variables with depression remained significant after controlling for a measure of the spouse's objective disability. In hierarchical regression analyses, perceived loss of control and its interaction with CATN significantly predicted follow-up depression after controlling for initial depression. The interaction showed that loss of control combined with an internal attribution predicted higher depression than did either one alone. The importance of including specific uncontrollable events when studying the RLH model is emphasized. (36 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Revisiting neighbourhood change from a Canadian perspective: Some supporting evidence from Vancouver

This paper argues that the several models of neighbourhood change developed in the United States are generally not applicable to Canadian cities due to differences in urban form, socioeconomic characteristics, and a host of institutional factors. A simple model is presented which extends the arbitrage model of neighbourhood dynamics. Several hypotheses are advanced and then tested on a data base covering three Vancouver, B.C. neighbourhoods from 1955 to 1981 by estimating several hedonic price equations. The hypotheses receive partial support. Implications for policymakers are then discussed.We wish to thank Jim Fitzsimmons and Judy Fountain for their computer assistance and the British Columbia Assessment Authority for providing us with data. Helpful comments on an earlier version of this paper were provided by Lawrence Jones and Douglas Diamond. We also like to acknowledge the financial support of the Canada Mortgage and Housing Corporation, the Real Estate Council of British Columbia, the University of British Columbia and the British Columbia Youth Employment Program.     

On the nature of self-monitoring: Matters of assessment, matters of validity.

Notes that an extensive network of empirical relations has been identified in research on the psychological construct of self-monitoring. Nevertheless, in recent years some concerns have been expressed about the instrument used for the assessment of self-monitoring propensities, the Self-Monitoring Scale (SMS) developed by the 1st author (see record 1975-03047-001). Both the extent to which the SMS taps an interpretable and meaningful causal variable and the extent to which the self-monitoring construct provides an appropriate theoretical understanding of this causal variable have been questioned. An examination of reanalyses of studies of self-monitoring, analyses of the internal structure of the SMS, and further relevant data suggests that the measure does tap a meaningful and interpretable causal variable with pervasive influences on social behavior, a variable reflected as a general self-monitoring factor. The evaluation and furthering of the interpretation of this latent causal variable are discussed, criteria for evaluating alternative measures of self-monitoring are offered, and a new 18-item SMS is presented. (88 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Addressing the special concerns of landfill closures: VLDPE and textured geomembranes

Landfill closures often require a somewhat different set of properties for synthetic liners than do landfill bottom liner installations. In particular, cap design usually presents the geotechnical engineer with greater concerns regarding long-term slope stability and accommodation of differential settlement. Friction between synthetic liners and materials contacting those liners, multiaxial elongation, and flexibility increase in importance. Since leachate does not contact the liners, chemical resistance becomes less important. Resistance to the components of landfill gas is, in most cases, all that is necessary.

As a result, synthetic liners with a textured surface to improve friction angles, and very low density polyethylene (VLDPE) geomembranes are becoming very attractive to geotechnical engineers. They provide considerable improvement in those areas which are important for cap installation. These materials, however, behave differently in standard index and performance testing of geomembranes, when compared with traditional polyethylene liners. These behaviors and differences are important for geotechnical engineers to understand. They are discussed in this paper.     

Two-degree-of-freedom output feedback controllers for discrete-time nonlinear systems

A discrete-time, model-based output feedback control structure for nonlinear processes is developed in the present work. The structure makes use of a closed-loop observer, while at the same time it guarantees that the overall feedback controller possesses integral action. An algebraic transformation is applied on the observer states to insure that the input/output gain of the observer matches the model upon which the static state feedback control law is based. The resulting control algorithm is a two-degree-of-freedom control law, in the sense that the output and the set point are processed in different ways. The control structure is shown not only to have the same properties as the standard model-state feedback structure, but also that it emerges from a model algorithmic control framework. Finally, a simulation example using an exothermic CSTR operating at an open-loop unstable steady state is used to evaluate the closed-loop performance of the proposed method.     

Reliability and stability of executive functioning in older adults.

A number of methodological questions have been raised about the reliability and validity of measuring executive functioning (EF) across multiple time points. In this study, correlational and latent-variable analyses were used to examine test-retest reliability of 5 common measures of EF and the stability of a latent EF construct. One hundred eighteen nondemented older adults were tested twice over a 4- to 8-week period. Findings demonstrated modest reliability of individual EF measures but very high stability of a latent EF construct. Relative contributions of each measure to the latent EF factor did not change across measurement trials. In addition, age-related effects on EF were similar at the 2 time points and were within the expected range. Implications for future studies of EF are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)