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121.
Statistical approaches in speech technology, whether used for statistical language models, trees, hidden Markov models or neural networks, represent the driving forces for the creation of language resources (LR), e.g., text corpora, pronunciation and morphology lexicons, and speech databases. This paper presents a system architecture for the rapid construction of morphologic and phonetic lexicons, two of the most important written language resources for the development of ASR (automatic speech recognition) and TTS (text-to-speech) systems. The presented architecture is modular and is particularly suitable for the development of written language resources for inflectional languages. In this paper an implementation is presented for the Slovenian language. The integrated graphic user interface focuses on the morphological and phonetic aspects of language and allows experts to produce good performances during analysis. In multilingual TTS systems, many extensive external written language resources are used, especially in the text processing part. It is very important, therefore, that representation of these resources is time and space efficient. It is also very important that language resources for new languages can be easily incorporated into the system, without modifying the common algorithms developed for multiple languages. In this regard the use of large external language resources (e.g., morphology and phonetic lexicons) represent an important problem because of the required space and slow look-up time. This paper presents a method and its results for compiling large lexicons, using examples for compiling German phonetic and morphology lexicons (CISLEX), and Slovenian phonetic (SIflex) and morphology (SImlex) lexicons, into corresponding finite-state transducers (FSTs). The German lexicons consisted of about 300,000 words, SIflex consisted of about 60,000 and SImlex of about 600,000 words (where 40,000 words were used for representation using finite-state transducers). Representation of large lexicons using finite-state transducers is mainly motivated by considerations of space and time efficiency. A great reduction in size and optimal access time was achieved for all lexicons. The starting size for the German phonetic lexicon was 12.53 MB and 18.49 MB for the morphology lexicon. The starting size for the Slovenian phonetic lexicon was 1.8 MB and 1.4 MB for the morphology lexicon. The final size of the corresponding FSTs was 2.78 MB for the German phonetic lexicon, 6.33 MB for the German morphology lexicon, 253 KB for SIflex and 662 KB for the SImlex lexicon. The achieved look-up time is optimal, since it only depends on the length of the input word and not on the size of the lexicon. Integration of lexicons for new languages into the multilingual TTS system is easy when using such representations and does not require any changes in the algorithms used for such lexicons. 相似文献
122.
Michal Cibulka Maria Brodnanova Marian Grendar Jan Necpal Jan Benetin Vladimir Han Egon Kurca Vladimir Nosal Matej Skorvanek Branislav Vesely Andrea Stanclova Zora Lasabova Zuzana Ps Tomas Szemes Stanislav Stuchlik Milan Grofik Martin Kolisek 《International journal of molecular sciences》2022,23(3)
SLC41A1 (A1) SNPs rs11240569 and rs823156 are associated with altered risk for Parkinson’s disease (PD), predominantly in Asian populations, and rs708727 has been linked to Alzheimer’s disease (AD). In this study, we have examined a potential association of the three aforementioned SNPs and of rs9438393, rs56152218, and rs61822602 (all three lying in the A1 promoter region) with PD in the Slovak population. Out of the six tested SNPs, we have identified only rs708727 as being associated with an increased risk for PD onset in Slovaks. The minor allele (A) in rs708727 is associated with PD in dominant and completely over-dominant genetic models (ORD = 1.36 (1.05–1.77), p = 0.02, and ORCOD = 1.34 (1.04–1.72), p = 0.02). Furthermore, the genotypic triplet GG(rs708727) + AG(rs823156) + CC(rs61822602) might be clinically relevant despite showing a medium (h ≥ 0.5) size difference (h = 0.522) between the PD and the control populations. RandomForest modeling has identified the power of the tested SNPs for discriminating between PD-patients and the controls to be essentially zero. The identified association of rs708727 with PD in the Slovak population leads us to hypothesize that this A1 polymorphism, which is involved in the epigenetic regulation of the expression of the AD-linked gene PM20D1, is also involved in the pathoetiology of PD (or universally in neurodegeneration) through the same or similar mechanism as in AD. 相似文献
123.
This determination of the mitochondrial effect of pharmacologically different antidepressants (agomelatine, ketamine and vortioxetine) was evaluated and quantified in vitro in pig brain-isolated mitochondria. We measured the activity of mitochondrial complexes, citrate synthase, malate dehydrogenase and monoamine oxidase, and the mitochondrial respiratory rate. Total hydrogen peroxide production and ATP production were assayed. The most potent inhibitor of all mitochondrial complexes and complex I-linked respiration was vortioxetine. Agomelatine and ketamine inhibited only complex IV activity. None of the drugs affected complex II-linked respiration, citrate synthase or malate dehydrogenase activity. Hydrogen peroxide production was mildly increased by agomelatine, which might contribute to increased oxidative damage and adverse effects at high drug concentrations. Vortioxetine significantly reduced hydrogen peroxide concentrations, which might suggest antioxidant mechanism activation. All tested antidepressants were partial MAO-A inhibitors, which might contribute to their antidepressant effect. We observed vortioxetine-induced MAO-B inhibition, which might be linked to decreased hydrogen peroxide formation and contribute to its procognitive and neuroprotective effects. Mitochondrial dysfunction could be linked to the adverse effects of vortioxetine, as vortioxetine is the most potent inhibitor of mitochondrial complexes and complex I-linked respiration. Clarifying the molecular interaction between drugs and mitochondria is important to fully understand their mechanism of action and the connection between their mechanisms and their therapeutic and/or adverse effects. 相似文献
124.
Early prediction of natural disasters like floods and landslides is essential for reasons of public safety. This can be attained by processing Synthetic-Aperture Radar (SAR) images and retrieving soil-moisture parameters. In this article, TerraSAR-X product images are investigated in combination with a water-cloud model based on the Shi semi-empirical model to determine the accuracy of soil-moisture parameter retrieval. SAR images were captured between January 2008 and September 2010 in the vicinity of the city Maribor, Slovenia, at different incidence angles. The water-cloud model provides acceptable estimated soil-moisture parameters at bare or scarcely vegetated soil areas. However, this model is too sensitive to speckle noise; therefore, a pre-processing step for speckle-noise reduction is carried out. Afterwards, self-organizing neural networks (SOM) are used to segment the areas at which the performance of this model is poor, and at the same time neural networks are also used for a more accurate approximation of model parameters’ values. Ground-truth is measured using the Pico64 sensor located on the field, simultaneously with capturing SAR images, in order to enable the comparison and validation of the obtained results. Experimental results show that the proposed method outperforms the water-cloud model accuracy over all incidence angles. 相似文献
125.
Matej Marinč 《Electronic Commerce Research》2013,13(1):71-101
This paper evaluates the impact of information technology (IT) on the operations of banks and the structure of the banking industry, including implications for stability. On the one hand, banks can focus on relationship banking and use IT developments to tailor services to individual needs and build enhanced, albeit modified, relationships with customers. On the other hand, IT better allows banks to exploit economies of scale and scope, which are most evident in transaction banking. Another manifestation of IT is via financial innovations that have enhanced marketability. Stability enters the picture because increased marketability facilitates opportunistic behavior. Together with enhanced herding behavior and changes in industry structure, this could undermine stability and augment systemic risk, calling for a regulatory overhaul. 相似文献
126.
A great number of tomographic systems, especially those equipped with fast data acquisition techniques, scan the objects investigated by divergent (fan) X-ray beams. Fan-beam projection data require special reconstruction techniques to be implemented. Among reconstruction techniques from parallel projection data, the direct Fourier method (DFM) proved to be one of the most promising ones, especially for high-speed image reconstruction in the high-end 3-D and dynamic tomographic systems. The goal of this work is to answer the topical question: how would direct use of the DFM influence the quality of image reconstruction from the fan-beam data? The formula describing the error caused by such an approximation is derived. The conclusions deduced from the formula are confirmed by computer simulations. The boundary values of data acquisition geometry parameters have been estimated for the case of using the DFM without recalculating the fan-beam data. 相似文献
127.
128.
Abstract Increased and more rigorous demands for power station operation in order to minimize both the cost of electrical energy production and environment pollution, addressed the necessity for optimisation of all segments of the process. As a consequence, there are certain needs for the introduction of new experimental methods which would ensure effective diagnostics. A newly developed experimental method for thermovisional detection of the temperature field in natural draft cooling towers is presented in this paper. The method is adapted to the real conditions that are present inside cooling towers and enables spatial‐ and time‐dependent detection of local temperatures in the region of drift eliminators of natural draft cooling towers. Combined with the previously developed methods for detection of velocity and temperature fields, the thermovision method enables quick detection of the local efficiency of cooling towers. Results of the method can be used for diagnostics of local and integral characteristics of cooling tower operation. Apart from this, they enable prediction of local corrections in order to increase the cooling tower efficiency. 相似文献
129.
Shih-Hsi Liu Marjan Mernik Dejan Hrnčič Matej Črepinšek 《Applied Soft Computing》2013,13(9):3792-3805
Exploration and exploitation are omnipresent terms in evolutionary computation community that have been broadly utilized to explain how evolutionary algorithms perform search. However, only recently exploration and exploitation measures were presented in a quantitative way enabling to measure amounts of exploration and exploitation. To move a step further, this paper introduces a parameter control approach that utilizes such measures as feedback to adaptively control evolution processes. The paper shows that with new exploration and exploitation measures, the evolution process generates relatively well results in terms of fitness and/or convergence rate when applying to a practical chemical engineering problem of fitting Sovova's model. We also conducted an objective statistical analysis using Bonferroni–Dunn test and sensitivity analysis on the experimental results. The statistical analysis results again proved that the parameter control strategy using exploration and exploitation measures is competitive to the other approaches presented in the paper. The sensitivity analysis results also showed that different initial values may affect output in different magnitude. 相似文献
130.
Abhishek Tripathi Arto Klami Matej Orešič Samuel Kaski 《Data mining and knowledge discovery》2011,23(2):300-321
Multi-view learning studies how several views, different feature representations, of the same objects could be best utilized in learning. In other words, multi-view learning is analysis of co-occurrence data, where the observations are co-occurrences of samples in the views. Standard multi-view learning such as joint density modeling cannot be done in the absence of co-occurrence, when the views are observed separately and the identities of objects are not known. As a practical example, joint analysis of mRNA and protein concentrations requires mapping between genes and proteins. We introduce a data-driven approach for learning the correspondence of the observations in the different views, in order to enable joint analysis also in the absence of known co-occurrence. The method finds a matching that maximizes statistical dependency between the views, which is particularly suitable for multi-view methods such as canonical correlation analysis which has the same objective. We apply the method to translational metabolomics, to identify differences and commonalities in metabolic processes in different species or tissues. The metabolite identities and roles in the different species are not generally known, and it is necessary to search for a matching. In this paper we show, using different metabolomics measurement batches as the views so that the ground truth is known, that the metabolite identities can be reliably matched by a consensus of several matching solutions. 相似文献