Understanding Urban Conservation Controls in Australian Cities

During the last decade or so, several Australian governments have developed controls to preserve the built environment. The necessity of such controls derives from the form of the development of industrial capitalism over the last century, and particularly the more recent development of the ‘corporate city’.

The recent development of specific site controls and planning legislation implicitly recognises this and reflects the ‘public good’ nature of conservation, and the necessity for inclusion in the general twentieth century state intrusion. Conservation is thus, it is concluded, more a question of political economy than taste and aesthetics.     

Two Cases of Pancytopenia with Coombs-Negative Hemolytic Anemia after Chimeric Antigen Receptor T-Cell Therapy

Background: Chimeric antigen receptor (CAR) T-cells are changing the therapeutic landscape of hematologic malignancies. Severe side effects include cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), but prolonged cytopenia has also been reported. The underlying mechanism for prolonged cytopenia is poorly understood so far. Cases: Severe pancytopenia with grade 2-3 anemia was marked 2–3 months after treatment. Laboratory evaluation revealed undetectable levels of haptoglobin with increased reticulocyte counts. Coomb’s tests were negative, no schistocytes were detected on blood smear, and infectious causes were ruled out. Increased erythropoiesis without lymphoma infiltration was noted on bone marrow biopsy. A spontaneous increase in haptoglobin and hemoglobin levels was observed after several weeks. For one patient, peripheral CAR-T levels were monitored over time. We observed a decline at the same time as hemoglobin levels began to rise, implying a potential causality. Conclusion: To our knowledge, we describe the first two cases of Coombs-negative hemolytic anemia after CAR-T treatment for B-cell lymphoma. We encourage routine monitoring for hemolytic anemia after CAR-T treatment and also encourage further investigations on the underlying mechanism.     

Rundschau

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Milch und K?se

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Rundschau

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Rundschau

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G?rungserscheinungen

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