Efficacy of lonidamine combined with different DNA-damaging agents in the treatment of the MX-1 tumor xenograft

The a.c. conductivity of the proteins lysozyme and subtilisin, both in their active and inactive or inhibited forms were determined theoretically. For this, quantum mechanical calculations and a random walk theory were used. The conclusions are that these enzymatic proteins can easily transport electrons which is most probably important in their role as catalysators of biochemical reactions. The electron transport is sensitive to three-dimensional changes of the active sites of these enzymes which have more flexibility than the whole molecule. Therefore, the flexibility of the active sites of enzyme catalysts is not only important for the conformational fitting with the reactants, but also strongly influences the transport in biochemical reactions.     

Time dispersion in large plastic scintillation neutron detectors

Time dispersion (TD) is computed for large neutron detectors using plastic scintillators. It is shown that TD seen by the photomultiplier (PM) tube does not necessarily increase with incident neutron energy, which is a result not fully in agreement with the usual finding     

Salvage chemotherapy with mitomycin, vindesine, and cisplatin (MiViP) in recurrent carcinoma of the cervix

We report two cases of metastatic non-functioning pancreatic endocrine tumour with very elevated plasma levels of alpha-fetoprotein. In these two cases, serial plasma levels of alpha-fetoprotein, initially normal, correlated well with hepatic tumour progression and were associated with fatal outcome. These results suggest that elevated plasma concentration of alpha-fetoprotein may be caused by metastatic pancreatic endocrine tumour and than alpha-fetoprotein serial measurement may be useful in prognostic evaluation.     

Diffusion bonding of an aluminium-lithium alloy (AA8090) using aluminium-copper alloy interlayers

Diffusion bonds have been produced between sheets of an Al-Li-Cu-Mg-Zr alloy using aluminium-4% copper vapour deposited metallic interlayers. Microstructural changes occurred both in the parent alloy and in the bond interface after diffusion bonding cycles and post-bonding heat treatments were analysed. Different metallographic techniques (light microscopy, scanning and transmission electron microscopy) have been used. Diffusion bonding trials were carried out using the same alloy (AA8090), both in non-superplastic (T6) and superplastic conditions. Differences in their behaviours in relation to diffusion bonding were observed.     

Crystallinity variations in kaolinite induced by grinding and pressure treatments

Kaolinite samples treated with uniaxial pressures higher than 0.1 GPa or grinding times greater than 0.3 h show changes in their crystallinity. These changes are easily detected by the X-ray diffraction (XRD) technique and can be quantified from Hinckley (HI), Lietard (R₂) and also reference intensity ratio (RIR) index studies. The sensitivity of these indices to the Crystallinity changes is; HI>RIR>R₂. In the range of pressures and grinding times considered, these values can be diminished by 50%. The variations in these indices with either the pressure or grinding time follow logarithmic laws whose correlation coefficients are closed to unity. Infrared (IR) spectroscopy and thermal analysis studies show low sensitivity to the changes introduced by grinding or pressure. Nevertheless, thermal gravimetric curves confirm the decrease in the dehydroxylation starting point of about 100°C for the pressed and ground samples. Transmission electron microscopy (TEM) reveals important changes in kaolinite particle morphologies after pressure and grinding treatments. The samples compressed at 0.1, 0.32, 0.85, 1.0 and 2.0 GPa show a large number of defects (fractures, bending, deformations and rolling of layers, glide and rotation of the shell). The ground samples show grain boundaries, dislocations, twins and rounded voids. These defects are responsible for the decrease in crystallinity of the kaolinite samples shown in the XRD and IR studies.     

Fast acquisition clock and data recovery circuit with low jitter

This paper presents a half-rate clock and data recovery circuit (CDR)that combines the fast acquisition of a phase selection (PS) delay-locked loop (DLL) with the low jitter of a phase-locked loop (PLL). The PLL acquisition time improves considerably with use of a phase frequency magnitude detector(PFMD) that feeds back an estimate of the magnitude of the frequency difference in addition to the sign. Measurements in 0.5/spl mu/m CMOS technology show operation up to 700 Mb/s, a 7% acquisition range, an initial acquisition time of 8 bit times with jitter of 30% bit time, and jitter of 16 ps after the PLL acquires lock. With a phase frequency detector (PFD), the PLL locks in about 700 ns from an initial frequency difference of 7%. Measurements using a PFMD show the 700 ns PLL acquisition time is reduced on average by about a factor of 5 to 140 ns from an initial 7% frequency difference. The power dissipation is 300mW.     

业务穿越ATM-PON的延时和延时变化研究

ATM-PON是光纤接入网的重要技术。文章研究了业务穿越ATM-PON接入网的延时和延时变化性能，着重分析媒体接入控制协议对业务延时和延时变化性能的影响。研究结论对ATM-PON媒体接入控制协议的合理设计有很大的帮助。     

The geometric nature of plasticity laws

This paper concerns the plasticity constitutive laws in small strain. In the thermodynamic approach developed here, the key concept is that of internal variables. The differential nature of plasticity law has been pointed out for a long time. If we unite the invariance condition of these laws in a state variable transformation, this involves, ultimately, that the natural mathematic frame of plasticity theory is Differential Geometry. The system state is defined as a point of a differentiable manifold. The state variable are the local coordinates of this point in a chart. The internal stresses are the components of a covariant vector of the cotangent bundle to internal state manifold and the elastic domain is a convex part of cotangent vector space. The plastic yield criteria such as von Mises condition define a Riemannian structure over the manifold. The metric element is identified with the internal dissipation element. Constitutive laws link the covariant derivatives of the thermodynamic stress with the state variable. Hardening modulus splits up in two parts, kinematic hardening and metric hardening. This last is defined by Christoffel connection coefficients. Applied to von Mises isotropic yield condition, the metric hardening is identified with isotropic hardening. The Baltov-Sawczuk model is also analysed. The use of appropriate polar coordinates simplifies significantly the computations. Generalization to a significant category of non-differentiable yield criteria, such as Tresca condition, is considered by introducting a metric tensor family. The adaptation of Drucker's postulate to the proposed model requires the introduction of parallel transport of the internal stress covector. Generally, this transport is different over distinctive paths joining two points. This fact expresses internal state manifold curvature. The Riemann-Christoffel tensor is computed for von Mises, Baltov-Sawczuk and Tresca models.     

On-body propagation velocity estimation using ultra-wideband frequency-domain spatial correlation analyses

On-body communications around the human torso are considered, using ultra-wideband transmissions. The velocity of the diffracted wave propagating around the body is extracted from frequency- domain spatial correlation analyses.