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71.
72.
Milad Ghomlaghi Anthony Hart Nhan Hoang Sungyoung Shin Lan K. Nguyen 《International journal of molecular sciences》2021,22(13)
The PI3K/mTOR signalling pathway plays a central role in the governing of cell growth, survival and metabolism. As such, it must integrate and decode information from both external and internal sources to guide efficient decision-making by the cell. To facilitate this, the pathway has evolved an intricate web of complex regulatory mechanisms and elaborate crosstalk with neighbouring signalling pathways, making it a highly non-linear system. Here, we describe the mechanistic biological details that underpin these regulatory mechanisms, covering a multitude of negative and positive feedback loops, feed-forward loops, competing protein interactions, and crosstalk with major signalling pathways. Further, we highlight the non-linear and dynamic network behaviours that arise from these regulations, uncovered through computational and experimental studies. Given the pivotal role of the PI3K/mTOR network in cellular homeostasis and its frequent dysregulation in pathologies including cancer and diabetes, a coherent and systems-level understanding of the complex regulation and consequential dynamic signalling behaviours within this network is imperative for advancing biology and development of new therapeutic approaches. 相似文献
73.
Prediction of Vibrational Behavior of Composite Cylindrical Shells under Various Boundary Conditions
In this paper, a unified analytical approach is applied to investigate the vibrational behavior of composite cylindrical shells. Theoretical formulation is established based on Sanders’ thin shell theory. The modal forms are assumed to have the axial dependency in the form of Fourier series whose derivatives are legitimized using Stoke's transformation. The Influence of some commonly used boundary conditions and the effect of variations in shell geometrical parameters on the shell frequencies are studied. The results obtained for a number of particular cases show good agreement with those available in the open literature. The simplicity and the capability of the present method are also discussed. 相似文献
74.
Ummugulsum Gunes Esra Bag Celik Cevahir C. Akgul Mehmet Koc Mohsen Ameri Bahri E. Uzuner Milad Ghasemi Mehmet C. Sahiner İlker Yildiz Hava Z. Kaya Selcuk Yerci Gorkem Gunbas 《Advanced functional materials》2021,31(42):2103130
Perovskite surface treatment with additives has been reported to improve charge extraction, stability, and/or surface passivation. In this study, treatment of a 3D perovskite ((FAPbI3)1−x(MAPbBr3)x) layer with a thienothiophene-based organic cation (TTMAI), synthesized in this work, is investigated. Detailed analyses reveal that a 2D (n = 1) or quasi-2D layer does not form on the PbI2-rich surface 3D perovskite. TTMAI-treated 3D perovskite solar cells (PSCs) fabricated in this study show improved fill factors, providing an increase in their power conversion efficiencies (PCEs) from 17% to over 20%. It is demonstrated that the enhancement is due to better hole extraction by drift-diffusion simulations. Furthermore, thanks to the hydrophobic nature of the TTMAI, PSC maintains 82% of its initial PCE under 15% humidity for over 380 h (the reference retains 38%). Additionally, semitransparent cells are demonstrated reaching 17.9% PCE with treated 3D perovskite, which is one of the highest reported efficiencies for double cationic 3D perovskites. Moreover, the semitransparent 3D PSC (TTMAI-treated) maintains 87% of its initial efficiency for six weeks (>1000 h) when kept in the dark at room temperature. These results clearly show that this study fills a critical void in perovskite research where highly efficient and stable semitransparent perovskite solar cells are scarce. 相似文献
75.
Mahmoudian Mehdi Poursattar Marjani Ahmad Hasanzadeh Rezgar Moradian Milad Mamaghani Shishavan Sajjad 《Polymer Bulletin》2020,77(6):2837-2854
Polymer Bulletin - Alumina nanoparticles are among important metal oxides with specific properties but chemically incompatible with an organic matrix such as poly(methyl methacrylate) (PMMA). In... 相似文献
76.
Saberi Meead Rashidi Taha H. Ghasri Milad Ewe Kenneth 《Networks and Spatial Economics》2018,18(4):1051-1073
Networks and Spatial Economics - Travel demand can be viewed as a weighted and directed graph where nodes are the origins and destinations and links represent the trips between nodes. This paper... 相似文献
77.
Cornual pregnancy traditionally has been treated with laparotomy and either cornual resection or hysterectomy. Recently, more conservative operations have been developed, and operative laparoscopy has provided yet another management option. This report describes the conservative management of a large cornual ectopic pregnancy and reviews the techniques and outcomes of conservative repair that have been described in the literature. 相似文献
78.
This study aims to deepen our understanding of the underlying factors affecting the intention to continue using increasingly popular wearable technology. A new theoretical model is developed and validated to extend traditional technology acceptance theories by identifying several value drivers of the continuous intention and actual usage of wearable devices. Hypotheses were tested using partial least squares path modeling on data collected from 383 actual smartwatch users. The results provide wearable device manufacturers with practical guidance for optimizing competition strategies. They also offer policy-making insights for practitioners to promote better wearable devices on the market, especially during the early stages of adoption. 相似文献
79.
The purpose of this paper is to present a tri-band bandpass filter (BPF) with compact structure. This filter consists of 50 Ω transmission line, varactor diode, positive-intrinsic-negative (PIN) diode, symmetrical square-shaped half-loop resonator pair, and three pairs of rectangular half circle that a T-stub is placed in it. By using the add PIN and varactor diodes in the proposed structure, it is possible to connect and disconnect each band, and change the central frequency up to 400 MHz. In addition, there is a situation to disconnect and connect all three bands simultaneously and asynchronously (unconditionally). This filter contains a low ripple value in all three bands. In this regard, the maximum ripple value does not exceed 0.3 dB and rejection is greater than 25 dB in total stop-band. An experimental tri-band BPF has been developed for wireless fidelity, wireless local area network, and worldwide interoperability for microwaves access applications. The measured results are properly accommodated with simulated results. 相似文献
80.
Saeid Kazemzadeh Azad Milad Bybordiani Sina Kazemzadeh Azad Farqad K. J. Jawad 《Structural and Multidisciplinary Optimization》2018,58(6):2545-2563
During the past decades, the main focus of the research in steel truss optimization has been tailored towards optimal design under static loading conditions and limited work has been devoted to investigating the optimum structural design considering dynamic excitations. This study addresses the simultaneous size and geometry optimization problem of steel truss structures subjected to dynamic excitations. Using the well-known big bang-big crunch algorithm, the minimum-weight design of steel trusses is conducted under both periodic and non-periodic excitations. In the case of periodic excitations, in order to examine the effect of the exciting period of the dynamic load on the final results, the design instances are optimized under different exciting periods and the obtained results are compared. It is observed that by increasing the excitation period of the considered sinusoidal loading as well as the finite rise time of the non-periodic step force, the optimization results approach the minimum design weight obtained under the static loading counterpart. However, in the case of the studied rectangular periodic excitation, the results obtained do not approach the optimum design associated with the static loading case even for higher values of the exciting period. 相似文献