A potential trackable bone filler: Preparation and characterization

This study reported the synthesis of fluorescent hydroxyapatite/alginate/carbon quantum dots (HA/Alg/CQDs) nanocomposites via the co-precipitation technique. The N-doped CQDs as a new class of fluorescent materials were prepared by the citric acid pyrolysis method, with an average size around 4 nm. Physical, chemical, and optical properties of the synthesized nanocomposites were investigated by X-ray diffraction (XRD), Fourier-transformed infrared spectroscopy (FTIR), atomic force microscopy (AFM), field-emission scanning electron microscopy (FESEM), UV–visible spectroscopy, and photoluminescence (PL) spectroscopy, respectively. The PL spectroscopy data verified the favorable in vitro luminescent emission of the HA/Alg/CQDs nanocomposites in comparison with HA/Alg and HA samples. The XRD patterns of the prepared samples confirmed the formation of crystalline HA in all composites, possessing a Ca/P ratio around 1.5 as obtained by EDX elemental analysis. The FESEM analysis exhibited HA nanoplates that homogeneously distributed throughout the alginate matrix. Therefore, the synthesized nanocomposites could be regarded as potential trackable drug carriers for hard tissue engineering applications.     

Experimental determination of gas holdup and volumetric mass transfer coefficient in a jet bubbling reactor

The hydrodynamics and mass transfer characteristics of a lab-scale jet bubbling reactor(JBR) including the gas holdup, volumetric mass transfer coefficient and specific interfacial area were assessed experimentally investigating the influence of temperature, p H and superficial gas velocity. The reactor diameter and height were 11 and 30 cm,respectively. It was equipped with a single sparger, operating at atmospheric pressure, 20 and 40℃, and two p H values of 3 and 6. The height of the liquid was 23 cm, while the superficial gas velocity changed within 0.010–0.040 m·s~(-1) range. Experiments were conducted with pure oxygen as the gas phase and saturated lime solution as the liquid phase. The liquid-side volumetric mass transfer coefficient was determined under unsteady-state oxygen absorption in a saturated lime solution. The gas holdup was calculated based on the liquid height change, while the specific interfacial area was obtained by a physical method based on the bubble size distribution(BSD) in different superficial gas velocities. The results indicated that at the same temperature but different p H, the gas holdup variation was negligible, while the liquid-side volumetric mass transfer coefficient at the p H value of 6 was higher than that at the p H = 3. At a constant p H but different temperatures, the gas holdup and the liquid-side volumetric mass transfer coefficients at 40℃ were higher than that of the same at 20℃. A reasonable and appropriate estimation of the liquid-side volumetric mass transfer coefficient(kla) in a pilot-scale JBR was provided which can be applied to the design and scale-up of JBRs.     

Protein Kinase C as a Therapeutic Target in Non-Small Cell Lung Cancer

Driver-directed therapeutics have revolutionized cancer treatment, presenting similar or better efficacy compared to traditional chemotherapy and substantially improving quality of life. Despite significant advances, targeted therapy is greatly limited by resistance acquisition, which emerges in nearly all patients receiving treatment. As a result, identifying the molecular modulators of resistance is of great interest. Recent work has implicated protein kinase C (PKC) isozymes as mediators of drug resistance in non-small cell lung cancer (NSCLC). Importantly, previous findings on PKC have implicated this family of enzymes in both tumor-promotive and tumor-suppressive biology in various tissues. Here, we review the biological role of PKC isozymes in NSCLC through extensive analysis of cell-line-based studies to better understand the rationale for PKC inhibition. PKC isoforms α, ε, η, ι, ζ upregulation has been reported in lung cancer, and overexpression correlates with worse prognosis in NSCLC patients. Most importantly, PKC isozymes have been established as mediators of resistance to tyrosine kinase inhibitors in NSCLC. Unfortunately, however, PKC-directed therapeutics have yielded unsatisfactory results, likely due to a lack of specific evaluation for PKC. To achieve satisfactory results in clinical trials, predictive biomarkers of PKC activity must be established and screened for prior to patient enrollment. Furthermore, tandem inhibition of PKC and molecular drivers may be a potential therapeutic strategy to prevent the emergence of resistance in NSCLC.     

Design,Facile Synthesis and Characterization of Porphyrin-Zirconium-Ferrite@SiO2 Core-Shell and Catalytic Application in Cyclohexane Oxidation

Silicon - In this study, a new magnetic ZrFe2O4@SiO2-TCPP nanocatalyst with high efficiency was used for the oxidation of cyclohexane to cyclohexanone (Ke) and cyclohexanol (Al). The mesoporous...     

Large Scale Reservoirs System Operation Optimization: the Interior Search Algorithm (ISA) Approach

Reservoirs are built to provide a powerful tool to control and manage surface water resources in order to cover inconsistency between water resources and demands. Due to finite available water and the increasing demands for water especially in arid and semi-arid regions like Iran, reservoirs must be optimally operated in order to use water in the most efficient way. This study applies the Interior Search Algorithm (ISA) to solve large scale reservoirs system operation optimization problems. The ISA is a meta-heuristic algorithm inspired from a systematic methodology of architecture process and mirror work utilized by Persian designers for decoration. Unlike other meta-heuristic algorithms, the ISA just have one parameter to tune which is a great advantage. In this study the parameter of the ISA tuned automatically using a linear equation. A real-world one-reservoir operation problem (i.e. Karun-4) and two large scale benchmark problems (i.e. four-reservoir and ten-reservoir operation problem) were employed to show the effectiveness of the ISA. The results shows the high ability of the ISA to solve reservoirs system operation problems as it achieved solutions 99.97, 99.99 and 99.95 % of global optimum for Karun-4 reservoir, four-reservoir and ten-reservoir system operation problems, respectively. These results are the best results reported so far in the studied problems. Comparing results of the ISA with those of non-linear programming (NLP), linear programming (LP), genetic algorithm (GA) and other meta-heuristic algorithms indicates fast convergence to global optimum. Considering the results, it can be stated that the ISA is a powerful tool to optimize complex large scale reservoir system operation problems.     

Optimal Inter-Basin Water Allocation Using Crisp and Fuzzy Shapley Games

In recent years, uneven distribution of available water resources as well as increasing water demands and overexploiting the water resources have brought severe need for transferring water from basins having sufficient water to basins facing water shortages. Therefore, optimal allocation of shared water resources in water transfer projects, considering the utilities of different stakeholders, physical limitations of the system and socioeconomic criteria is an important task. In this paper, a new methodology based on crisp and fuzzy Shapley games is developed for optimal allocation of inter-basin water resources. In the proposed methodology, initial water allocations are obtained using an optimization model considering an equity criterion. In the second step, the stakeholders form crisp coalitions to increase the total net benefit of the system as well as their own benefits and a crisp Shapley Value game is used to reallocate the benefits produced in the crisp coalitions. Lastly, to provide maximum total net benefit, fuzzy coalitions are constituted and the participation rates of water users to fuzzy coalitions are optimized. Then, the total net benefit is reallocated to water users in a rational and equitable way using Fuzzy Shapley Value game. The effectiveness of this method is examined by applying it to a large scale case study of water transfer from the Karoon river basin in southern Iran to the Rafsanjan plain in central Iran.     

Optimizing the Runoff Estimation with HEC-HMS Model Using Spatial Evapotranspiration by the SEBS Model

Most of the commonly used hydrological models do not account for the actual evapotranspiration (ETa) as a key contributor to water loss in semi-arid/arid regions. In this study, the HEC-HMS (Hydrologic Engineering Center Hydrologic Modeling System) model was calibrated, modified, and its performance in simulating runoff resulting from short-duration rainfall events was evaluated. The model modifications included integrating spatially distributed ETa, calculated using the surface energy balance system (SEBS), into the model. Evaluating the model’s performance in simulating runoff showed that the default HEC-HMS model underestimated the runoff with root mean squared error (RMSE) of 0.14 m³/s (R²?=?0.92) while incorporating SEBS ETa into the model reduced RMSE to 0.01 m³/s (R²?=?0.99). The integration of HECHMS and SEBS resulted in smaller and more realistic latent heat flux estimates translated into a lower water loss rate and a higher magnitude of runoff simulated by the HECHMS model. The difference between runoff simulations using the default and modified model translated into an average of 95,000 m³ runoff per rainfall event (equal to seasonal water requirement of ten-hectare winter wheat) that could be planned and triggered for agricultural purposes, flood harvesting, and groundwater recharge in the region. The effect of ETa on the simulated runoff volume is expected to be more pronounced during high evaporative demand periods, longer rainfall events, and larger catchments. The outcome of this study signifies the importance of implementing accurate estimates of evapotranspiration into a hydrological model.

     

Heat transfer between an under-expanded jet and a cylindrical surface

This paper presents a selection of data from an investigation that was concerned with the heat transfer which occurs when an under-expanded jet impinges onto a heated cylindrical surface. The purpose of the study was to establish the thermal boundary conditions for calculating thermal stresses in heat transfer surfaces when subjected to high-speed cleaning jets. The heat transfer in the impingement zone of a high-speed jet is extremely high and when the presence of the surface interferes with the expansion of the jet, the radial and circumferential distributions of the heat transfer coefficient become complicated. If a highly under-expanded jet impinges upon the surface while the nozzle-to-surface spacing is small, z/D≈3, there is no longer a maximum stagnation heat transfer coefficient on the geometric axis of the jet, instead a stagnation ‘ring’ is formed with a radius of about one nozzle diameter. A selection of data is presented that shows how, particularly for z/D less than 10, the Nusselt number distribution has a very high peak value at, or near to, the geometric stagnation point and then falls away steeply in both the axial and circumferential directions. The high values of Nusselt number, and the large differences between the peak values on the front edge of the cylinder and the values at the rear of the cylinder, could lead to very substantial differential cooling rates and hence to significant thermal stresses being generated when high pressure air cleaning jets are used on high-temperature tubes. However, when the nozzle exit is placed more than 20 nozzle diameters away from the surface of the cylinder there is a significant reduction in the maximum Nusselt number and the overall distribution is much smoother; this will alleviate potential problems from thermal stresses.     

Performance Assessment of a Coupled Particle Swarm Optimization and Network Flow Programming Model for Optimum Water Allocation

Water resources allocation problems are mainly categorized in two classes of simulation and optimization. In most cases, optimization problems due to the number of variables, constraints and nonlinear feasible search space are known as a challenging subject in the literature. In this research, by coupling particle swarm optimization (PSO) algorithm and a network flow programming (NFP) based river basin simulation model, a PSO-NFP hybrid structure is constructed for optimum water allocation planning. In the PSO-NFP model, the NFP core roles as the fast inner simulation engine for finding optimum values for a large number of water discharges in the network links (rivers and canals) and nodes (reservoirs and demands) while the heuristic PSO algorithm forms the outer optimization cover to search for the optimum values of reservoirs capacities and their storage priorities. In order to assess the performance of the PSO-NFP model, three hypothetical test problems are defined, and their equivalent nonlinear mathematical programs are developed in LINGO and the results are compared. Finally, the PSO-NFP model is applied in solving a real river basin water allocation problem. Results indicate that the applied method of coupling PSO and NFP has an efficient ability for handling river basin-scale water resources optimization problems.     

Iran atlas of offshore renewable energies

The aim of the present study is to provide an Atlas of IRAN Offshore Renewable Energy Resources (hereafter called ‘the Atlas’) to map out wave and tidal resources at a national scale, extending over the area of the Persian Gulf and Sea of Oman. Such an Atlas can provide necessary tools to identify the areas with greatest resource potential and within reach of present technology development.To estimate available tidal energy resources at the site, a two-dimensional tidally driven hydrodynamic numerical model of Persian Gulf was developed using the hydrodynamic model in the MIKE 21 Flow Model (MIKE 21HD), with validation using tidal elevation measurements and tidal stream diamonds from Admiralty charts. The results of the model were used to produce a time series of the tidal stream velocity over the simulation period.Moreover, to assess the potential of the wave energy in this site, a model was developed based on six-hourly data from a third generation ocean wave model (ISWM-Iranian Sea Wave Model) covering the period 1992–2003.To ensure the information provided to the Atlas is managed and maintained most effectively, all the derived marine resource parameters have been captured in a structured database, within a Geographical Information System (GIS), so enabling effective data management, presentation and interrogation.