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21.
NI Goldstein M Prewett K Zuklys P Rockwell J Mendelsohn 《Canadian Metallurgical Quarterly》1995,1(11):1311-1318
The epidermal growth factor receptor (EGFR) is a protein tyrosine kinase expressed on many types of tumor cells, including breast, ovarian, bladder, head and neck, and prostatic carcinoma. There seems to be an association between up-regulation of the EGFR and poor clinical prognosis for a number of human cancers. The 225 antibody is a highly specific murine monoclonal antibody that binds specifically to the human EGFR with an affinity equal to its ligand, competes with the ligand for binding, and blocks activation of the receptor tyrosine kinase. In addition, 225 has been shown to inhibit the growth of human tumor xenografts in athymic nude mice. The 225 antibody has recently been chimerized with human IgG1 in its constant region to increase its clinical utility by decreasing the potential for generation of human antimouse antibodies in recipients. This report compares the biological effects of 225 and its chimeric counterpart (designated C225) against established A431 tumor xenografts in nude mice. The results of these experiments indicated that C225 was more effective than 225 in inhibiting tumor growth in this model. In addition, many of the animals treated with C225 were tumor free at the end of each treatment protocol. It was determined that the dissociation constant of C225 was about 5-fold lower than 225. This suggested that the increased capacity of C225 to compete with ligand for binding to the EGFR was responsible for its enhanced in vivo antitumor effect. 相似文献
22.
VA Demenev MA Shchinova LI Ivanov RN Vorob''eva NI Zdanovskaia NV Neba?kina 《Canadian Metallurgical Quarterly》1996,41(3):107-110
Nine female patients with a urethral diverticulum were admitted to our center over a six period: The clinical symptomatology was not specific. The diagnosis has been performed by voiding and retrograde cysto-uretrogram. The surgical treatment consisted in the excision of the diverticula, with the patient in the supine position. No perioperative morbidity was observed. 相似文献
23.
简要介绍了国内少有的干气催化部分氧化转化制氢工艺,重点讨论了转化水碳比的控制条件,对降低水碳比操作进行了有益地探讨。 相似文献
24.
The L-DOPA and sulpiridinum effects on the enzymatic transporting function of the enterocytes' membrane, were studied in rats under stress. The L-DOPA was shown to hinder the absorption rate of glucose, whereas sulpiridinum was shown to suppress the main enzymes excepting snerase and alkaline phosphatase, to increase the monomeric and hydrolysate glucose transport. The L-DOPA seems to play a modifying role in the regulation and integration of the digestive-transporting function of the enterocytes' membrane in rats under stress. 相似文献
25.
调质状态下40Cr钢的焊接 总被引:1,自引:0,他引:1
在合理制定焊接工艺的基础上,采用R307珠光体耐热钢焊条成功地进行40Cr钢在调质状态下的焊接,解决了通常采用25—13型奥氏体焊条焊接出现的焊缝强度低、焊接接头性能差的问题。 相似文献
26.
提出了ERP编码的原则,介绍了常见的四种编码方法:顺序码、分类码、结构码和组合码.最后结合实例介绍了编码系统中各模块的设计。 相似文献
27.
赵青南 《武汉理工大学学报(材料科学英文版)》2005,(4)
1Introduction Theultravioletrays(UV)insunlight(-4%)cantransmitintoroomthroughcommonfloatglass,theUVcanmakethematerialsintheroom,eg,paper,furni ture,textilefabricandplastics,becoloredanddeterio rated.ShieldingfromUVirradiationisofinterestinmanyfields.Formu… 相似文献
28.
29.
The dependence between the activity parameters of muscarine antagonists in the prevention of haloperidol catalepsy in rats and those in tests characterizing the interaction of ligands and various subtypes of m-cholinoceptors was studied. It was established by constructing the mathematical dependence that blockade of m1-cholinoceptors increases, while that of m2-cholinoceptors reduces the antiparkinsonian activity of the drugs. The activity of the muscarine antagonist pentiphan in the prevention of haloperidol-induced catalepsy in rats exceeds the activity of such traditional antiparkinsonian drugs as cyclodol and amedin. 相似文献
30.
30 patients were exposed to interference currents (IC) alone (group 1) versus 34 patients treated with IC plus iodobromine baths (group 2). After IC action on the region of the kidney projection patients of group 1 experienced positive changes in cellular and humoral immunity providing an antiinflammatory effect. In group 2, the improvement was seen in renal and urinary functions, 24-h urinary excretion of oxalates and calcium diminished. Interference current proved beneficial in chronic pyelonephritis patients with latent inflammation. The combined therapy was effective in patients at high risk of lithogenesis. 相似文献