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排序方式: 共有1224条查询结果,搜索用时 203 毫秒
91.
Toshihiko Myojo Akira Ogami Takako Oyabu Yasuo Morimoto Masami Hirohashi Masahiro Murakami Kenichiro Nishi Chikara Kadoya Isamu Tanaka 《Advanced Powder Technology》2010,21(5):507-512
Pulmonary health effects of fine particles and nanoparticles are overviewed in this paper, mainly based on the researches conducting in our laboratory. For the hazard assessment, we exposed rats to aerosolized asbestos-substitutes or nanoparticles aerosols (nickel oxide and titanium dioxide), and examined the biological and pathological effects of the particle on lung, a major target organ for the particles, and cytokines which are related to inflammation, fibrosis and carcinogenesis in the lung. It is essential to perform comprehensive evaluation of the toxicity of poorly soluble powder samples using the precise characterization data and exposure methods, such as single instillation or aerosol inhalation. 相似文献
92.
Satoshi Miyaguchi Shinichi Ishizuka Takeo Wakimoto Jun Funaki Yoshinori Fukuda Hirofumi Kubota Kenji Yoshida Teruichi Watanabe Hideo Ochi Tsuyoshi Sakamoto Masami Tsuchida Isamu Ohshita Teruo Tohma 《Journal of the Society for Information Display》1999,7(3):221-226
Abstract— A full-color 5.2-inch 1/4-VGA passive-matrix organic LED display has been developed, adopting selective deposition for the different emitting materials. The display features 320 (×3) × 240 pixels with an equivalent pixel size of 0.33 × 0.33 mm, white peak luminance of over 150 cd/m2, and power consumption of 6 W. 相似文献
93.
A Parashar AA Akhand R Rawar T Furuno M Nakanishi M Kato H Suzuki I Nakashima 《Canadian Metallurgical Quarterly》1999,26(1-2):227-231
The mechanism of the lymphocyte stimulatory action of sulfhydryl group-reactive mercuric ions was studied with respect to its potential ability to induce a protein tyrosine phosphorylation-linked signal for mobilization of free Ca2+ into cytoplasm and nucleus of the cell. Exposure of human leukamic T cell line (Jurkat) cells to high (1 mM) and low (0.01 mM) concentrations of HgCl2 induced tyrosine phosphorylation of multiple proteins in a concentration-dependent manner. Confocal microscopy directly visualized the time course localization of Ca2+ inside the cells after exposure to HgCl2. The onset and level of Ca2+ mobilization following HgCl2 exposure were in parallel to those of protein tyrosine phosphorylation. Interestingly, by either concentration of HgCl2, Ca2+ was mobilized in both cytoplasm and nucleus almost simultaneously, and the level of Ca2+ mobilization in the nucleus was more than that in the cytoplasm. All the HgCl2-mediated Ca2+ mobilization was prevented by addition of protein kinase inhibitor staurosporin prior to HgCl2. These results suggest that heavy metal stress triggers a protein tyrosine phosphorylation-linked signal that leads to a nuclear event-dominant Ca2+ mobilization. 相似文献
94.
95.
Takai Y. Fujita M. Nagata K. Isa S. Nakazawa S. Hirobe A. Ohkubo H. Sakao M. Horiba S. Fukase T. Takaishi Y. Matsuo M. Komuro M. Uchida T. Sakoh T. Saino K. Uchiyama S. Takada Y. Sekine J. Nakanishi N. Oikawa T. Igeta M. Tanabe H. Miyamoto H. Hashimoto T. Yamaguchi H. Koyama K. Kobayashi Y. Okuda T. 《Solid-State Circuits, IEEE Journal of》2000,35(2):149-162
This paper describes three circuit technologies indispensable for high-bandwidth multibank DRAM's. (1) A clock generator based on a bidirectional delay (BDD) eliminates the output skew. The BDD measures the cycle time as the quantity charged or discharged of an analog quantity, and replicates it in the next cycle. This achieves a 0.18-mm 2, two-cycle-lock clock generator operating from 25 to 167 MHz with a 30-ps resolution. (2) A quad-coupled receiver eliminates the internal skew caused by the difference between a rise input and a fall input by 40%. (3) An interbank shared redundancy scheme (ISR) with a variable unit redundancy (VUR) efficiently increases yield in multibank DRAM's. The ISR allows redundancy match circuits to be shared with two or more banks. The VUR allows the number of units replaced to be variable. These circuit technologies achieved a 250-Mb/s/pin, 8-bank, 1-Gb double-data-rate synchronous DRAM 相似文献
96.
Water and sodium experiments were conducted with scaled models to study the in-vessel thermal stratification. The models simulate the outlet plenum in a loop-type LMFBR with an inner barrel and a closed-type UIS (upper instrumentation structure). An examination of the threshold for thermal stratification, the rising rate of the stratification interface, and the flow regime above the interface has been conducted and is reported in the present paper. In parallel, the phenomenon in the experiments has been evaluated with the multi-dimensional analysis. 相似文献
97.
H Tachikawa W Funahashi Y Takeuchi H Nakanishi R Nishihara S Katoh XD Gao T Mizunaga D Fujimoto 《Canadian Metallurgical Quarterly》1997,239(3):710-714
The third multicopy suppressor gene of the PDI1 deletion from Saccharomyces cerevisiae, MPD2, was isolated and characterized. The MPD2 gene encodes a protein with a putative signal sequence, ER retention signal, and a disulfide isomerase active site like sequence. The amino acid sequence around the active site like sequence is similar to the thioredoxin-like domains of PDI and PDI related proteins, although the similarity is comparatively low. A delta-pdi1 strain over-producing Mpd2p showed slow growth and was sensitive to 1 mM dithiothreitol. Mpd2p can be detected in wild type cells and is a glycoprotein. Although the MPD2 gene was not essential for growth, overexpression of the gene partially restored the maturation defect of carboxypeptidase Y caused by the PDI1 deletion. Mutagenesis analysis revealed that Mpd2p can compensate for the loss of PDI with its CXXC sequence. 相似文献
98.
99.
This letter describes the successful fabrication of a 0.95Sn−0.05Au solder microbump on a compound semiconductor wafer by
reflowing of multi-layer metal film. Since the inherent interdiffusion in Au−Sn phases results in the alloying of multi-layer
films, the composition of micro-bump is well controlled by the thickness of constituent metal films. The micro-bumps melt
at about 220 C, which is close to the lowest eutectic temperature in a Au−Sn system. Solder bonding using 0.95Sn−0.05Au micro-bump
is a very useful technique for the flipchip bonding of compound semiconductor devices. 相似文献
100.
Summary The binding of fibrinogen with heparin and dextran sulfates, and of antithrombin III with heparin and dextran sulfate were investigated by sedimentation velocity method. From the measurement of fibrinogen-acidic polysaccharide systems, it was confirmed that heparin and low molecular weight dextran sulfate(DSC) forms soluble complexes with fibrinogen, though the amount bound of the latter was rather small compared with high molecular weight dextran sulfate(DSD). Antithrombin III was also found to be bound by heparin and DSC. The numbers of heparin molecules bound to one molecule of fibrinogen and antithrombin III were estimated to be 4.2 and 0.3, respectively. 相似文献