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51.
EL Wallace DM Surgenor HS Hao J An RH Chapman WH Churchill 《Canadian Metallurgical Quarterly》1993,33(2):139-144
A poor response to L-DOPA in addition to parkinsonian, cerebellar, and autonomic signs is commonly regarded as indicative of clinical multiple system atrophy (MSA). We compared the motor response to a single oral administration of 250 mg L-DOPA/25 mg carbidopa in eight MSA patients and eight Parkinson's disease (PD) patients with the "on-off" phenomenon, evaluating L-DOPA peripheral pharmacokinetics. Motor response was consistently good in all PD patients, but only four MSA patients had a (moderate) response. Pharmacokinetic parameters did not differ between the groups. The varying extent of putaminal damage could be responsible for the differing motor response to L-DOPA in MSA patients. 相似文献
52.
Mendes MP Ribeiro L Nascimento J Condesso de Melo T Stigter TY Buxo A 《Water science and technology》2012,66(10):2162-2169
The Water Framework Directive establishes that the river basin management plans must have a summary of the pressures and impacts of human activities, such as agriculture, on the chemical and quantitative status of groundwater bodies. In order to identify those areas where a potential impact from agricultural activities on groundwater bodies exists, but currently lacking groundwater monitoring data, a methodology was developed that combines the use of gross nitrogen balance values with the results of a specific vulnerability assessment index. A farm management efficiency parameter is added, to identify the factors that contribute to nitrogen use efficiency and to assess the near-future scenarios. This methodology allows the identification of significant pressures that may be responsible for a groundwater body failing good status where there is no representative monitoring network. 相似文献
53.
BCI Meeting 2005--workshop on signals and recording methods. 总被引:4,自引:0,他引:4
Jonathan R Wolpaw Gerald E Loeb Brendan Z Allison Emanuel Donchin Omar Feix do Nascimento William J Heetderks Femke Nijboer William G Shain James N Turner 《IEEE transactions on neural systems and rehabilitation engineering》2006,14(2):138-141
This paper describes the highlights of presentations and discussions during the Third International BCI Meeting in a workshop that evaluated potential brain-computer interface (BCI) signals and currently available recording methods. It defined the main potential user populations and their needs, addressed the relative advantages and disadvantages of noninvasive and implanted (i.e., invasive) methodologies, considered ethical issues, and focused on the challenges involved in translating BCI systems from the laboratory to widespread clinical use. The workshop stressed the critical importance of developing useful applications that establish the practical value of BCI technology. 相似文献
54.
E. P. Muniz J. R. C. Proveti R. D. Pereira B. Segatto P. S. S. Porto V. P. Nascimento M. A. Schettino E. C. Passamani 《Journal of Materials Science》2013,48(4):1543-1554
The kinetics of formation of NiFe2O4 nanoparticles were investigated where the nanoparticles were produced by the proteic-sol–gel method using coconut water followed by annealing in (i) air, (ii) air in the presence of boron nitride (BN), or (iii) nitrogen. The sample dried at 473 K for 5.5 h was composed of small disordered NiFe2O4 nanoparticles in a superparamagnetic state as determined from Mössbauer spectroscopy. In general, heat treatment at high temperature leads to a nanocomposite rich in NiFe2O4. In air, annealing at 1173 K for 8 h favored the formation of the magnetically ordered NiFe2O4 inverse spinel structure, with bulk characteristics and average crystal sizes of approximately 66 nm. In a nitrogen atmosphere and in compacted BN powder under air atmosphere, the NiFe2O4 spinel structure stabilized for temperatures up to 873 and 773 K, respectively, however, decomposition of the NiFe2O4 phase into other undesired structures was observed above 873 K. 相似文献
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Aula Alwattar Athir Haddad Quan Zhou Tatiana Nascimento Ryan Greenhalgh Eliton Medeiros Jonny Blaker Adam Parry Peter Quayle Stephen Yeates 《Polymer International》2019,68(3):360-368
Fluorescent markers are critical for tracking the position and movement of molecules both in vivo and in vitro. Conventionally, synthetic dyes are non‐covalently added to polymers for fluorescent tracking, but often diffuse away. Here we demonstrate, for the first time, a facile method for the synthesis of fluorescent poly(lactic acid) nano‐/microfibres for biomedical applications using solution spin blowing. Pyrene‐end‐capped poly(l ‐lactide) (PLLA) derivatives were synthesised using the ring‐opening polymerisation of l ‐lactide and they were characterised using spectroscopic and thermal analyses. Submicrometre‐sized fluorescent fibres were produced from these PLLA derivatives using solution blow spinning techniques generating polymer blends and core–shell fibres. Such system could be further exploited to incorporate electrically conductive carbon allotropes via the pyrene aromaticity, producing fluorescent and electrically active fibres for in vitro monitoring and electrical stimulation. © 2018 Society of Chemical Industry 相似文献
59.
Sirlene F. Lázaro Humberto Tonhati Hinayah R. Oliveira Alessandra A. Silva André V. Nascimento Daniel J.A. Santos Gabriela Stefani Luiz F. Brito 《Journal of dairy science》2021,104(5):5768-5793
Genomic selection has been widely implemented in many livestock breeding programs, but it remains incipient in buffalo. Therefore, this study aimed to (1) estimate variance components incorporating genomic information in Murrah buffalo; (2) evaluate the performance of genomic prediction for milk-related traits using single- and multitrait random regression models (RRM) and the single-step genomic best linear unbiased prediction approach; and (3) estimate longitudinal SNP effects and candidate genes potentially associated with time-dependent variation in milk, fat, and protein yields, as well as somatic cell score (SCS) in multiple parities. The data used to estimate the genetic parameters consisted of a total of 323,140 test-day records. The average daily heritability estimates were moderate (0.35 ± 0.02 for milk yield, 0.22 ± 0.03 for fat yield, 0.42 ± 0.03 for protein yield, and 0.16 ± 0.03 for SCS). The highest heritability estimates, considering all traits studied, were observed between 20 and 280 d in milk (DIM). The genetic correlation estimates at different DIM among the evaluated traits ranged from ?0.10 (156 to 185 DIM for SCS) to 0.61 (36 to 65 DIM for fat yield). In general, direct selection for any of the traits evaluated is expected to result in indirect genetic gains for milk yield, fat yield, and protein yield but also increase SCS at certain lactation stages, which is undesirable. The predicted RRM coefficients were used to derive the genomic estimated breeding values (GEBV) for each time point (from 5 to 305 DIM). In general, the tuning parameters evaluated when constructing the hybrid genomic relationship matrices had a small effect on the GEBV accuracy and a greater effect on the bias estimates. The SNP solutions were back-solved from the GEBV predicted from the Legendre random regression coefficients, which were then used to estimate the longitudinal SNP effects (from 5 to 305 DIM). The daily SNP effect for 3 different lactation stages were performed considering 3 different lactation stages for each trait and parity: from 5 to 70, from 71 to 150, and from 151 to 305 DIM. Important genomic regions related to the analyzed traits and parities that explain more than 0.50% of the total additive genetic variance were selected for further analyses of candidate genes. In general, similar potential candidate genes were found between traits, but our results suggest evidence of differential sets of candidate genes underlying the phenotypic expression of the traits across parities. These results contribute to a better understanding of the genetic architecture of milk production traits in dairy buffalo and reinforce the relevance of incorporating genomic information to genetically evaluate longitudinal traits in dairy buffalo. Furthermore, the candidate genes identified can be used as target genes in future functional genomics studies. 相似文献
60.
Igor A. Magno Fabrício A. Souza Marlo O. Costa Jacson M. Nascimento Adrina P. Silva Thiago S. Costa 《Materials Science & Technology》2019,35(7):791-806
Horizontal directional solidification and precipitation hardening experiments were performed with the Al5.5Si3Cu alloy. Solidification thermal and microstructural parameters such as growth and cooling rates (VL and TR, respectively) and the secondary dendrite arm spacing (λ2) were determined experimentally. As-solidified samples were selected and submitted to the T6-heat treatment (T6-HT). The T6-HT was carried out considering two solution times: 8 and 5?h at 490?±?2°C, followed by quenching in warm water (60?±?2°C), aging for 5?h at 155?±?2°C and air-cooling. Higher HV values were observed for the solution time of 5 h. As highlights of this work, the influence of the processing parameters (VL, TR and λ2) on the distribution, morphology and size of the eutectic Si particles has been investigated. 相似文献