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11.
k-nearest neighbor (k-NN) queries are well-known and widely used in a plethora of applications. However, in the original definition of k-NN queries there is no concern regarding diversity of the answer set with respect to the user’s interests. For instance, travelers may be looking for touristic sites that are close to where they are, but that would also lead them to see different parts of the city. Likewise, if one is looking for restaurants close by, it may be more interesting to learn about restaurants of different categories or ethnicities which are nonetheless relatively close. The interesting novel aspect of this type of query is that there are two competing criteria to be optimized: closeness and diversity. We propose two approaches that leverage the notion of linear skyline queries in order to find the k diverse nearest neighbors within a radius r from a given query point, or (k, r)-DNNs for short. Our proposed approaches return a relatively small set containing all optimal solutions for any linear combination of the weights a user could give to the two competing criteria, and we consider three different notions of diversity: spatial, categorical and angular. Our experiments, varying a number of parameters and exploring synthetic and real datasets, in both Euclidean space and road networks, respectively, show that our approaches are several orders of magnitude faster than a straightforward approach. 相似文献
12.
Thamires Rodrigues de Sousa Beatriz Oliveira Fagundes Andrezza Nascimento Lorena Abreu Fernandes Fbio da Ressureio Sgnotto Raquel Leo Orfali Valria Aoki Alberto Jos da Silva Duarte Sabri Saeed Sanabani Jefferson Russo Victor 《International journal of molecular sciences》2022,23(12)
Atopic dermatitis (AD) is a common relapsing inflammatory skin disorder characterized by immune-mediated inflammation and epidermal barrier dysfunction. The pathogenesis of AD is multifactorial and has not been fully elucidated to date. This study aimed to evaluate whether serum IgG from adult AD patients could modulate the thymic maturation of IL-22-producing T cells and CLA+ T cells of non-atopic infants. Given that miRNAs regulate immune response genes, we evaluated whether miRNA expression is also altered in cultured thymocytes. Thymocytes were cultured with purified IgG from AD patients or control conditions (mock, Intravenous-IgG (IVIg), non-atopic IgG, or atopic non-AD IgG). Using flow cytometry analysis, we assessed the expression of CLA and intracellular levels of IL-4, IFN-γ, and IL-22 on double-positive T cells (DP T), CD4 T cells, or CD8 T cells. We also investigated the frequency of IgG isotypes and their direct interaction with the thymic T cells membrane. The miRNA profiles were evaluated by the Illumina small RNA-seq approach. MiRNA target gene prediction and enrichment analyses were performed using bioinformatics. Increased frequencies of IL-22 and CLA+ producing CD4+ T cells cultured with IgG of AD patients was seen in non-atopic infant thymocytes compared to all control conditions. No alterations were observed in the frequency of IgG isotypes among evaluated IgG pools. Evidence for a direct interaction between IgG and thymic DP T, CD4 T, and CD8 T cells is presented. The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR-342-3p, has-miR-148a-3p, has-miR-92a and has-miR-4492). The prediction of the targetome of the seven dysregulated miRNAs between AD and mock control revealed 122 putative targets, and functional and pathway enrichment analyses were performed. Our results enhance our understanding of the mechanism by which IgG can collaborate in thymic T cells in the setting of infant AD. 相似文献
13.
Luana Beatriz dos Santos Nascimento Massimiliano Tattini 《International journal of molecular sciences》2022,23(9)
Plants evolved an impressive arsenal of multifunctional specialized metabolites to cope with the novel environmental pressures imposed by the terrestrial habitat when moving from water. Here we examine the multifarious roles of flavonoids in plant terrestrialization. We reason on the environmental drivers, other than the increase in UV-B radiation, that were mostly responsible for the rise of flavonoid metabolism and how flavonoids helped plants in land conquest. We are reasonably based on a nutrient-deficiency hypothesis for the replacement of mycosporine-like amino acids, typical of streptophytic algae, with the flavonoid metabolism during the water-to-land transition. We suggest that flavonoids modulated auxin transport and signaling and promoted the symbiosis between plants and fungi (e.g., arbuscular mycorrhizal, AM), a central event for the conquest of land by plants. AM improved the ability of early plants to take up nutrients and water from highly impoverished soils. We offer evidence that flavonoids equipped early land plants with highly versatile “defense compounds”, essential for the new set of abiotic and biotic stressors imposed by the terrestrial environment. We conclude that flavonoids have been multifunctional since the appearance of plants on land, not only acting as UV filters but especially improving both nutrient acquisition and biotic stress defense. 相似文献
14.
E. P. Muniz J. R. C. Proveti R. D. Pereira B. Segatto P. S. S. Porto V. P. Nascimento M. A. Schettino E. C. Passamani 《Journal of Materials Science》2013,48(4):1543-1554
The kinetics of formation of NiFe2O4 nanoparticles were investigated where the nanoparticles were produced by the proteic-sol–gel method using coconut water followed by annealing in (i) air, (ii) air in the presence of boron nitride (BN), or (iii) nitrogen. The sample dried at 473 K for 5.5 h was composed of small disordered NiFe2O4 nanoparticles in a superparamagnetic state as determined from Mössbauer spectroscopy. In general, heat treatment at high temperature leads to a nanocomposite rich in NiFe2O4. In air, annealing at 1173 K for 8 h favored the formation of the magnetically ordered NiFe2O4 inverse spinel structure, with bulk characteristics and average crystal sizes of approximately 66 nm. In a nitrogen atmosphere and in compacted BN powder under air atmosphere, the NiFe2O4 spinel structure stabilized for temperatures up to 873 and 773 K, respectively, however, decomposition of the NiFe2O4 phase into other undesired structures was observed above 873 K. 相似文献
15.
16.
Igor A. Magno Fabrício A. Souza Marlo O. Costa Jacson M. Nascimento Adrina P. Silva Thiago S. Costa 《Materials Science & Technology》2019,35(7):791-806
Horizontal directional solidification and precipitation hardening experiments were performed with the Al5.5Si3Cu alloy. Solidification thermal and microstructural parameters such as growth and cooling rates (VL and TR, respectively) and the secondary dendrite arm spacing (λ2) were determined experimentally. As-solidified samples were selected and submitted to the T6-heat treatment (T6-HT). The T6-HT was carried out considering two solution times: 8 and 5?h at 490?±?2°C, followed by quenching in warm water (60?±?2°C), aging for 5?h at 155?±?2°C and air-cooling. Higher HV values were observed for the solution time of 5 h. As highlights of this work, the influence of the processing parameters (VL, TR and λ2) on the distribution, morphology and size of the eutectic Si particles has been investigated. 相似文献
17.
18.
The ability to discriminate nestmates from non-nestmates in insect societies is essential to protect colonies from conspecific invaders. The acceptance threshold hypothesis predicts that organisms whose recognition systems classify recipients without errors should optimize the balance between acceptance and rejection. In this process, cuticular hydrocarbons play an important role as cues of recognition in social insects. The aims of this study were to determine whether guards exhibit a restrictive level of rejection towards chemically distinct individuals, becoming more permissive during the encounters with either nestmate or non-nestmate individuals bearing chemically similar profiles. The study demonstrates that Melipona asilvai (Hymenoptera: Apidae: Meliponini) guards exhibit a flexible system of nestmate recognition according to the degree of chemical similarity between the incoming forager and its own cuticular hydrocarbons profile. Guards became less restrictive in their acceptance rates when they encounter non-nestmates with highly similar chemical profiles, which they probably mistake for nestmates, hence broadening their acceptance level. 相似文献
19.
The preparation of the 11.7Li2O–39.7WO3–10.9CaO–37.7P2O5 glass (pgLWCP) was based on a one-step heat treatment of the 6Li2O–18WO3–43CaO–33P2O5 (gLWCP) glass followed by leaching of the β-Ca2P2O7 phase formed during the crystallization process. The porous structure was formed in the region formerly occupied by the β-Ca2P2O7 phase. The gLWCP undergoes devitrification through surface crystallization. This process occurs after a thermal treatment in lower temperature and in a shorter period of time than that required for the complete crystallization. After acid leaching treatment, we obtained a core-/shell-like structure with a very well-defined dense glass (gLWCP)/porous glass (pgLWCP) interface. The pgLWCP exhibits reversible coloration–decoloration reactions. 相似文献
20.
Gleber Tacio Teixeira Rosana Ftima Teixeira Lomba Agatha Densy dos Santos Francisco Joo Francisco Cajaíba da Silva Regina Sandra Veiga Nascimento 《应用聚合物科学杂志》2014,131(12)
To prevent the degradation of the borehole and also the disintegration and dispersion of drilled cuttings, different shale stabilizing additives are used in water‐based drilling fluids (WBFs). Glycols, poly(ethylene glycol), glycerols, and polyglycerol derivatives, also called polyols, have been used to inhibit shales containing reactive clays in WBF. These additives are normally used in conjunction with KCl to reduce clay swelling and dispersion of drilled cuttings. Highly branched polymers have become an important field in current polymer science. Such materials typically exhibit compact, globular structures in combination with an exceptionally high number of sites with functional groups. They have unique properties that differ significantly from their linear counterparts, and the hyperbranched polyglycerol (hPG) is an important hyperbranched polymer that can be produced from an environmentally benign monomer, the glycerol carbonate. In this article, the clay inhibitive properties of hPG were evaluated by different test methods including bentonite inhibition test, cuttings recovery, and X‐ray diffraction measurements. The results show that the hPG has a great potential to be used as an environmental friendly inhibitor additive in WBFs. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131, 40384. 相似文献